Bioassays


Book Description

Bioassays: Advanced Methods and Applications provides a thorough understanding of the applications of bioassays in monitoring toxicity in aquatic ecosystems. It reviews the newest tests and applications in discovering compounds and toxins in the environment, covering all suitable organisms, from bacteria, to microorganisms, to higher plants, including invertebrates and vertebrates. By learning about newer tests, water pollution control testing can be less time and labor consuming, and less expensive. This book will be helpful for anyone working in aquatic environments or those who need an introduction to ecotoxicology or bioassays, from investigators, to technicians and students. - Features chapters written by internationally renowned researchers in the field, all actively involved in the development and application of bioassays - Gives the reader an understanding of the advantages and deficiencies of available tests - Addresses the problem of understanding the impact of toxins in an aquatic environment and how to assess them







Bioassay Techniques for Drug Development


Book Description

The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa




Environmental Bioassay Techniques and their Application


Book Description

Proceedings of the First International Conference held in Lancaster, England, July 11-14, 1988




Analytical Techniques in Environmental Chemistry 2


Book Description

Analytical Techniques in Environmental Chemistry 2 focuses on the establishment of analytical techniques in the management of compounds relative to their effects on health and nature. The book stresses that these analytical techniques are essential in order to cope with the problems arising from the utilization of these compounds. The selection contains the contributions of authors who have continuously performed studies on the analysis of organic and inorganic pollutants and monitoring strategies or case histories of compounds. These pieces focus on the role of analytical chemistry in the control of compounds, particularly if the compounds are seen to pose threat to health and the environment. The text presents studies on the determination of how these compounds can become pollutants, which are emphasized by the experiments and laboratory procedures mentioned in the book. Through research on hazardous compounds in different areas, the book manages to point out the differences of how these compounds can affect the environment and health. The text then proceeds by presenting various analytical techniques that could be employed to mitigate the hazardous nature of these compounds. The book is a reliable source of information for scholars and readers who are interested in studying how to control the hazardous effects of compounds both on health and the environment.




Beyond the Molecular Frontier


Book Description

Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.




Experiments in Environmental Chemistry


Book Description

Experiments in Environmental Chemistry presents experimental activities that provide practical, first hand experience in the observation of chemical processes occurring in the environment. A variety of techniques with applications in governmental laboratories, industry, and research are described. The experiments are divided into five parts: biochemical processes in aquatic systems; toxic substances in the environment; food additives and contaminants; chemical ecology; and field surveys. This book is divided into five sections and begins with a discussion on the transformations of carbon, nitrogen, phosphorus, and energy in aquatic systems. Various aspects of environmental chemistry including photosynthesis, respiration, biogeochemical cycling, primary production, plant nutrients, water quality, eutrophication, and wastewater treatment are considered. The next section focuses on a wide assortment of environmental contaminants in terms of their behavior and occurrence in various sectors of the environment. In this section, the reader is introduced to gas chromatography, atomic absorption spectroscopy, thin layer chromotography, column chromatography, and techniques for the measurement of atmospheric contaminants. Food and the occurrence of foreign substances that result from deliberate additions or other processes are also analyzed, along with chemical compounds such as allelochemicals, pheromones, and chemical defense substances. This monograph will be a valuable resource for environmental chemists.




Chemical and Biological Terrorism


Book Description

The threat of domestic terrorism today looms larger than ever. Bombings at the World Trade Center and Oklahoma City's Federal Building, as well as nerve gas attacks in Japan, have made it tragically obvious that American civilians must be ready for terrorist attacks. What do we need to know to help emergency and medical personnel prepare for these attacks? Chemical and Biological Terrorism identifies the R&D efforts needed to implement recommendations in key areas: pre-incident intelligence, detection and identification of chemical and biological agents, protective clothing and equipment, early recognition that a population has been covertly exposed to a pathogen, mass casualty decontamination and triage, use of vaccines and pharmaceuticals, and the psychological effects of terror. Specific objectives for computer software development are also identified. The book addresses the differences between a biological and chemical attack, the distinct challenges to the military and civilian medical communities, and other broader issues. This book will be of critical interest to anyone involved in civilian preparedness for terrorist attack: planners, administrators, responders, medical professionals, public health and emergency personnel, and technology designers and engineers.




Issues in Risk Assessment


Book Description

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.




EPA-430/1


Book Description