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Clinical Bioenergetics

Author : Sergej M. Ostojic

Publisher : Academic Press

Page : 720 pages

File Size : 42,92 MB

Release : 2020-11-12

Category : Science

ISBN : 0128227729

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Book Description

Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. - Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics - Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders - Features chapter contributions from international leaders in translational bioenergetics research and clinical practice



Bioenergetics 2

Author : David G. Nicholls

Publisher : Academic Press

Page : 276 pages

File Size : 40,45 MB

Release : 2014-06-28

Category : Science

ISBN : 1483214206

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Book Description

Bioenergetics 2 aims to clarify topics such as the thermodynamics of bioenergetic processes and the stoichiometries of energy coupling reactions. The book discusses chemiosmotic energy transduction; ion transport across energy-conserving membranes; and quantitative bioenergenetics as the measurement of driving forces. The text also describes the chemiosmotic proton circuit; the respiratory chain; the photosynthetic generators of protonmotive force; and the ATP synthase. The secondary transport of products across the membrane, as well as the structures of the bacterial photosynthetic reaction center and bacteriorhodopsin are also considered. Biochemists will find the book invaluable.



Bioenergetics

Author : David G. Nicholls

Publisher : Academic Press

Page : 434 pages

File Size : 32,23 MB

Release : 2013-05-20

Category : Science

ISBN : 0123884314

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Book Description

Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. - BMA Medical Book Awards 2014-Highly Commended, Basic and Clinical Sciences,2014,British Medical Association - Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology - Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins - Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging - Offers readers clear, visual representation of structural concepts through full colour figures throughout the book



Principles of Bioenergetics

Author : Vladimir P. Skulachev

Publisher : Springer Science & Business Media

Page : 435 pages

File Size : 12,19 MB

Release : 2012-12-15

Category : Science

ISBN : 364233430X

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Book Description

Principles of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry. Bioenergetics concerns energy transductions occurring in living systems and this book pays special attention to molecular mechanisms of these processes. The main subject of the book is the "energy coupling membrane" which refers to inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases) are also part of this membrane. Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants.



Foundations of Bioenergetics

Author : Harold Morowitz

Publisher : Elsevier

Page : 365 pages

File Size : 50,33 MB

Release : 2012-12-02

Category : Science

ISBN : 0323154050

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Book Description

Foundations of Bioenergetics provides an introduction to the physical foundations of bioenergetics and the methods of applying these constructs to biological problems. It combines parts of thermal physics, biochemistry, ecology, and cellular and organismic biology into a single coherent work. Much of the material in this volume comes from ""Entropy for Biologists,"" an introductory thermodynamics book aimed particularly at life scientists. Some of the topics originally appeared in the monograph ""Energy Flow in Biology."" The current volume expands on that material with respect to biological applications and attempts to bridge the gap between physics and biology. The book explains basic concepts such as energy, temperature, the second law of thermodynamics, entropy, information theory, and statistical mechanics. It discusses the relations between thermodynamics and statistical mechanics, free-energy functions, radiant energy, the free energy of cells and tissue, chemical kinetics, and cyclic flows. It examines the relationships between energy flows and biological processes; applications of the concepts of Gibbs free energy, chemical potential, and activity; and measurements of temperature, energy, and thermochemical quantities. The book also includes chapters that deal with irreversible dynamics, irreversible theory, and osmotic flow.



Bioenergetics

Author : Davor Juretic

Publisher : CRC Press

Page : 288 pages

File Size : 44,49 MB

Release : 2021-12-23

Category : Science

ISBN : 1351172751

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Book Description

Bioenergetics deals with the very first energy transformation steps performed by living cells. Increased dissipation is the primary effect of processing external energy packages. Enzyme-supported charge separation is the minor but essential outcome for maintaining life. This book explores the usefulness of dissecting the entropy production of enzymes involved in cellular defenses, fermentation, respiration, and photosynthesis, assuming that tightly regulated dissipation is the hallmark of life. Researchers, educators, and students of life sciences can find in this text many examples of how we can use the interdisciplinary approach to study cells' virtuoso ability to connect the microscopic to the macroscopic world. Each chapter is a self-contained unit with a glossary and selected references for further reading.



Bioenergetics

Author : David G. Nicholls

Publisher : Elsevier

Page : 332 pages

File Size : 32,34 MB

Release : 2002-07-03

Category : Science

ISBN : 0080527930

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Book Description

This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. It takes account of the many newly determined structures, such as ATP synthase and the two photosystems of photosynthesis, that provide molecular insight into chemiosmotic energy transduction. This edition includes additional color figures of protein structures and many newly drawn illustrations designed to enable the reader to grasp the fundamental insights that are derived from knowing the structure. Every chapter has been extensively revised and updated and a new chapter on the study of the bioenergetics of mitochondria in the intact cell is included to satisfy the enormous interest in this topic. Written for students and researchers alike, this book is the most current text on the chemiosmotic theory and membrane bioenergetics available.Key Features* Chapter on the study of bioenergetics of mitochondria in the intact cell* Appendix listing protein structure resources* Additional colour plates of protein structures* Many newly drawn illustrations* Website



Bioenergetics

Author : Lars Garby

Publisher : Cambridge University Press

Page : 290 pages

File Size : 49,90 MB

Release : 1995-02-24

Category : Medical

ISBN : 9780521451437

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Book Description

The original authors-see later for detail



Biochemistry: Fundamentals and Bioenergetics

Author : Meera Yadav

Publisher : Bentham Science Publishers

Page : 441 pages

File Size : 42,64 MB

Release : 2021-10-29

Category : Science

ISBN : 1681088487

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Book Description

Biochemistry: Fundamentals and Bioenergetics presents information about the basic and applied aspects of the chemistry of living organisms. The textbook covers the scope and importance of biochemistry, the latest physical techniques to determine biomolecular structure, detailed classification, structure and function of biomolecules such as carbohydrates, lipids, amino acids, proteins, nucleic acids, vitamins, enzymes and hormones. Readers will also learn about processes central to energy metabolism including photosynthesis and respiration, oxidative phosphorylation, DNA replication, transcription and translation, recombinant DNA technology. Key Features - logical approach to biochemistry with several examples - 10 organized chapters on biochemistry fundamentals and metabolism - focus on biomolecules and biochemical processes - references for further reading



Molecular System Bioenergetics

Author : Valdur Saks

Publisher : John Wiley & Sons

Page : 633 pages

File Size : 36,85 MB

Release : 2008-01-08

Category : Science

ISBN : 3527621105

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Book Description

In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.