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Biologic Markers in Reproductive Toxicology

Author : National Research Council

Publisher : National Academies Press

Page : 424 pages

File Size : 35,94 MB

Release : 1989-02-01

Category : Social Science

ISBN : 9780309039796

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Book Description

Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.



Biologic Markers in Urinary Toxicology

Author : National Research Council

Publisher : National Academies Press

Page : 322 pages

File Size : 40,29 MB

Release : 1995-08-28

Category : Science

ISBN : 0309052289

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Book Description

Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).





Drinking Water and Health,

Author : National Research Council

Publisher : National Academies Press

Page : 476 pages

File Size : 46,96 MB

Release : 1986-02-01

Category : Nature

ISBN : 0309036879

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Book Description

The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.



Measuring Lead Exposure in Infants, Children, and Other Sensitive Populations

Author : National Research Council

Publisher : National Academies Press

Page : 356 pages

File Size : 47,82 MB

Release : 1993-02-01

Category : Science

ISBN : 030904927X

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Book Description

Lead is a ubiquitous toxic agent that is especially damaging to the young child and the developing fetus. Unlike many environmental health risks, the risks associated with lead are no longer theoretical but have been observed for many years. Indeed, the first regulation of lead in paint was enacted in the 1920s. Currently, because of growing evidence of lead toxicity at lower concentrations, the U.S. Centers for Disease Control and Prevention recently lowered its lead-exposure guideline to 10 ug/dl lead in blood from 25 ug/dl. Measuring Lead Exposure in Infants, Children, and Other Sensitive Populations addresses the public health concern about the logistics and feasibility of lead screening in infants and children at such low concentrations. This book will serve as the basis for all U.S. Public Health Service activities and for all state and local programs in monitoring lead.



Environmental Neurotoxicology

Author : National Research Council

Publisher : National Academies Press

Page : 167 pages

File Size : 11,90 MB

Release : 1992-02-01

Category : Science

ISBN : 0309045312

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Book Description

Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.



Environmental Epidemiology, Volume 1

Author : National Research Council

Publisher : National Academies Press

Page : 297 pages

File Size : 46,83 MB

Release : 1991-01-01

Category : Science

ISBN : 0309044960

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Book Description

The amount of hazardous waste in the United States has been estimated at 275 million metric tons in licensed sites alone. Is the health of Americans at risk from exposure to this toxic material? This volume, the first of several on environmental epidemiology, reviews the available evidence and makes recommendations for filling gaps in data and improving health assessments. The book explores: Whether researchers can infer health hazards from available data. The results of substantial state and federal programs on hazardous waste dangers. The book presents the results of studies of hazardous wastes in the air, water, soil, and food and examines the potential of biological markers in health risk assessment. The data and recommendations in this volume will be of immediate use to toxicologists, environmental health professionals, epidemiologists, and other biologists.



Biomarkers in Toxicology

Author : Ramesh C Gupta

Publisher : Academic Press

Page : 1149 pages

File Size : 44,17 MB

Release : 2014-01-25

Category : Technology & Engineering

ISBN : 0124046495

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Book Description

Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. - Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers - Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes - Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more



Biologic Markers of Air-Pollution Stress and Damage in Forests

Author : National Research Council

Publisher : National Academies Press

Page : 377 pages

File Size : 37,2 MB

Release : 1989-01-01

Category : Technology & Engineering

ISBN : 0309040787

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Book Description

There is not much question that plants are sensitive to air pollution, nor is there doubt that air pollution is affecting forests and agriculture worldwide. In this book, specific criteria and evaluated approaches to diagnose the effects of air pollution on trees and forests are examined.



Biologic Markers in Pulmonary Toxicology

Author : National Research Council

Publisher : National Academies Press

Page : 204 pages

File Size : 23,85 MB

Release : 1989-02-01

Category : Science

ISBN : 9780309039901

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Book Description

Biologic markersâ€"indicators of biological exposure or changeâ€"offer the promise of early detection of disease caused by environmental exposure. Researchers have used these markers to discover indications of pulmonary damage from low-level ozone, a finding with serious implications for health professionals and environmental regulators. Biologic Markers in Pulmonary Toxicology is a comprehensive study of this use of biologic markers. Focusing on the respiratory tract as an entryway for airborne pollutants, this volume reviews new ways of measuring markers, the need for markers to indicate dose or exposure levels, noninvasive respiratory function tests for use with healthy humans to detect sensitivity to inhaled pollutants, approaches to evaluating markers down to the cellular and biochemical levels, and more.