› › Cancer Stem Cells Basic Concept And Therapeutic Implications

The Heterogeneity of Cancer Metabolism

Author : Anne Le

Publisher : Springer

Page : 186 pages

File Size : 50,8 MB

Release : 2018-06-26

Category : Medical

ISBN : 331977736X

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Book Description

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.



The Cancer Stem Cell Niche

Author : Susie Nilsson

Publisher : Academic Press

Page : 246 pages

File Size : 39,61 MB

Release : 2021-02-09

Category : Science

ISBN : 0323853250

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Book Description

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche



Cancer Stem Cells: New Horizons in Cancer Therapies

Author : Surajit Pathak

Publisher : Springer Nature

Page : 369 pages

File Size : 26,79 MB

Release : 2020-10-17

Category : Medical

ISBN : 9811551200

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Book Description

This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.



Cancer Stem Cells

Author : Vinagolu K. Rajasekhar

Publisher : John Wiley & Sons

Page : 0 pages

File Size : 25,95 MB

Release : 2014-04-14

Category : Science

ISBN : 9781118356166

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Book Description

Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.



Cancer Stem Cells

Author : Lucie Laplane

Publisher : Harvard University Press

Page : 265 pages

File Size : 12,52 MB

Release : 2016-06-06

Category : Medical

ISBN : 0674088743

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Book Description

Part IV: The Identity of Stemness and Its Consequences for Cancer Therapies -- Chapter 7. If Stemness Is a Categorical or a Dispositional Property, How Can We Cure Cancers? -- Chapter 8. If Stemness Is a Relational or a Systemic Property, How Can We Cure Cancers? -- Conclusion -- Notes -- References -- Acknowledgments -- Index



Cancer Stem Cells in Lung Cancer

Author : Koji Okudela

Publisher : Nova Biomedical Books

Page : 0 pages

File Size : 45,26 MB

Release : 2011

Category : Cancer cells

ISBN : 9781617282959

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Book Description

Of the many markers for cancer stem cells (CSCs) in lung cancer reported to date, the cell surface antigen CD133, nuclear ß-catenin accumulation, the side population phenotype, and high aldehyde dehydrogenase (ALDH) activity seem to be most reliable. This book reviews the results of studies on lung CSCs and discusses the significance of these markers from a biological, pathological, and clinical viewpoint. Twenty-seven lung cancer cell lines (nine small cell lung carcinoma (SCLC) cell lines and eighteen non-small cell lung carcinoma (NSCLC) cell lines) were examined for mRNA and protein expression and fractions of cells with activity.



Cancer Stem Cells: Basic Concept and Therapeutic Implications

Author : Farhadul Islam

Publisher : Springer Nature

Page : 375 pages

File Size : 33,90 MB

Release : 2023-07-26

Category : Medical

ISBN : 9819931851

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Book Description

This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications. ​



Human Cell Transformation

Author : Johng S. Rhim

Publisher : Springer Science & Business Media

Page : 239 pages

File Size : 42,20 MB

Release : 2011-09-15

Category : Science

ISBN : 1461402549

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Book Description

Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: · Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems · Oncogenes · Tumor suppressor genes · Viral transformation · In vitro model systems for viral, chemical and radiation carcinogenesis · Cell aging · The multistep nature of human carcinogenesis · The role of stem cells and the microenvironment in tumorigenesis · The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features ؠ Multistep models ؠ Breast cancer/Stem cells ؠ Prostate cancer/Stem cells ؠ Multistep / Genes



Stem Cells and Cancer Stem Cells, Volume 11

Author : M.A. Hayat

Publisher : Springer

Page : 0 pages

File Size : 42,5 MB

Release : 2016-08-23

Category : Medical

ISBN : 9789402407501

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Book Description

Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods.



Metastatic Cancer: Clinical and Biological Perspectives

Author : Rahul Jandial

Publisher : CRC Press

Page : 312 pages

File Size : 46,58 MB

Release : 2013-08-08

Category : Medical

ISBN : 9781587066597

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Book Description

Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.