Chromatography Applied to Quality Testing


Book Description

"This very useful booklet is packed with information about using chromatography. Many examples are given of tests and trials to determine the quality of soils and compost, but also of select crop plants. This classic is an informative and scientific work by Ehrenfried Pfeiffer, an early biodynamic pioneer. A critical part of the serious biodynamic practitioner's library. Color chromatograms help the reader visualize the application. Contents include: The art and science of composting A qualitative chromatographic method for the determination of biological factors Studies of vitamin preparations Chromatograms of grain and flour"










Chromatography


Book Description

Chromatography is a widely-used scientific technique used to separate complex compounds into their components. Ehrenfried Pfeiffer, a respected chemist and pioneer of biodynamics, developed a specific chromatographical method which produces a picture (a 'chromatogram') which shows the quality of a substance or organism. The technique can be usefully applied to research in areas such as agriculture, nutrition, soils and composts.This pamphlet, which includes 56 colour chromatograms, offers an overview of all aspects of chromatography, as well as detailed accounts of various tests, studies and trials to determine the quality of soils and compost, and particular plants.




Applications of Ion Chromatography for Pharmaceutical and Biological Products


Book Description

This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing. In addition, an appendix section gives information on critical physical and chromatographic parameters related to IC and information on current manufacturers of IC systems, columns, and other components.




Dietary Supplement Test Methods: Liquid Chromatography Separation Techniques And Application


Book Description

This book describes the analytical approach to testing over 160 important dietary supplement ingredients. In addition to the methods, there is significant guidance provided on how to develop, modify, and improve testing techniques. The procedures in this book include some of the most modern technologies that are available in the laboratory today. These basic principles of method development and troubleshooting can be implemented for food and food safety testing, drug development research, and agricultural areas. The contents of this book contain a very comprehensive collection of valuable analytical tools.




Validation of Chromatography Data Systems


Book Description

Chromatography is a major analytical technique that is used throughout research, development and manufacturing in the pharmaceutical, medical device and associated industries. To demonstrate fitness for purpose with the applicable regulations, the systems must be validated. Validation of Chromatography Data Systems: Meeting Business and Regulatory Requirements introduces the basics of computer validation. It looks in detail at the requirements throughout the life cycle of a CDS for any regulated laboratory, from its concept, through writing the user requirements specification to selecting the system, testing and operational release, including using electronic signatures. This logical and uniquely organised book provides the background to the regulatory requirements, interpretation of the regulations and documented evidence needed to support a claim that a system is validated. Development of the system, risk management, operation and finally system retirement and data migration are discussed. Case studies and practical examples are provided where appropriate. Validation of Chromatography Data Systems: Meeting Business and Regulatory Requirements is ideal for the chromatographer working in analytical laboratories in the regulated pharmaceutical, contract research, biotechnology and medical device industries seeking the practical guidance required for validating their chromatography data systems in order to meet regulatory requirements. It will also be welcomed by consultants or those in regulatory agencies.




The Essence of Chromatography


Book Description

General concepts in column chromatography -- The column in gas chromatography -- Instrumental aspects of gas chromatography -- The column in liquid chromatography -- Instrumental aspects of liquid chromatography -- Thin-layer chromatography -- Supercritical fluid chromatography -- Capillary-electromigration separation techniques -- Spectroscopic detectors for identification and quantification -- Separation of stereoisomers -- Laboratory-scale preparative chromatography.




Forensic Applications of Gas Chromatography


Book Description

Several areas of forensic science use the technique of gas chromatography, ranging from fire analysis to the investigation of fraudulent food and perfumes. Covering the essentials of this powerful analytical technique, Forensic Applications of Gas Chromatography explains the theory and shows applications of this knowledge to various realms of forensic science. Topics include: A brief introduction to gas chromatography and its use in forensic science Various components that make up the gas chromatographic instrumentation The theory of the separation process, along with the chemistry underpinning the process Method development, with a specific example of a separation of eight different compounds using a gas chromatography-flame ionization detector Quality assurance and method validation—with information applicable to many types of analytical testing laboratories Troubleshooting in gas chromatography systems New developments in gas chromatography and advances in columns and detectors Real examples supplement the text, along with questions in each chapter. The book includes examples of applications of gas chromatography in drugs, toxicology, fire, paint, food, and fragrance. Each application is presented as an individual case study with specific focus on a particular sample preparation technique. This allows each technique to be discussed with respect to its theory, instrumentation, solvent selection, and function, as appropriate. Each case study provides readers with suitable practical information to allow them to perform experiments in their own laboratory either as part of a practical laboratory class or in a research context. The final chapter provides answers to the questions and encourages further study and discussion.




Practical High-Performance Liquid Chromatography


Book Description

Jump into the HPLC adventure! Three decades on from publication of the 1st German edition of Veronika Meyer's book on HPLC, this classic text remains one of the few titles available on general HPLC aimed at practitioners. New sections on the following topics have been included in this fifth edition: Comparison of HPLC with capillary electrophoresis How to obtain peak capacity van Deemter curves and other coherences Hydrophilic interaction chromatography Method transfer Comprehensive two-dimensional HPLC Fast separations at 1000 bar HPLC with superheated water In addition, two chapters on the instrument test and troubleshooting in the appendix have been updated and expanded by Bruno E. Lendi, and many details have been improved and numerous references added. A completely new chapter is presented on quality assurance covering: Is it worth the effort? Verification with a second method Method validation Standard operating procedures Measurement uncertainty Qualifications, instrument test, and system suitability test The quest for quality Reviews of earlier editions "That this text is written by an expert in both the practice and teaching of HPLC is evident from the first paragraph....not only an enjoyable, fascinating and easy read, but a truly excellent text that has and will serve many teachers, students and practitioners very well." —The Analyst “…provides essential information on HPLC for LC practitioners in academia, industry, government, and research laboratories…a valuable introduction." - American Journal of Therapeutics