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Correlation-based network analysis of cancer metabolism

Author : Emily G. Armitage

Publisher : Springer

Page : 67 pages

File Size : 25,52 MB

Release : 2014-05-12

Category : Science

ISBN : 1493906151

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Book Description

With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.



The Heterogeneity of Cancer Metabolism

Author : Anne Le

Publisher : Springer

Page : 186 pages

File Size : 19,95 MB

Release : 2018-06-26

Category : Medical

ISBN : 331977736X

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Book Description

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.



NMR-based Metabolomics

Author : Hector C Keun

Publisher : Royal Society of Chemistry

Page : 384 pages

File Size : 36,45 MB

Release : 2018-01-17

Category : Medical

ISBN : 184973643X

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Book Description

This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.



Data Integration in the Life Sciences

Author : Bertram Ludäscher

Publisher : Springer

Page : 344 pages

File Size : 15,53 MB

Release : 2005-07-08

Category : Computers

ISBN : 9783540279679

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Book Description

This book constitutes the refereed proceedings of the Second International Workshop on Data Integration in the Life Sciences, DILS 2005, held in San Diego, CA, USA in July 2005. The 20 revised full papers presented together with 8 revised posters and demonstration papers, 2 keynote articles and 5 invited position statements were carefully reviewed and selected from 50 initial submissions. The papers are organized in topical sections on user applications, ontologies, data integration, and others and address all current issues in data integration from the life science point of view.



Cancer as a Metabolic Disease

Author : Thomas Seyfried

Publisher : John Wiley & Sons

Page : 482 pages

File Size : 38,61 MB

Release : 2012-05-18

Category : Science

ISBN : 1118310306

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Book Description

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.



How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General

Publisher :

Page : 728 pages

File Size : 33,24 MB

Release : 2010

Category : Government publications

ISBN :

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Book Description

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.



Statistics for High-Dimensional Data

Author : Peter Bühlmann

Publisher : Springer Science & Business Media

Page : 568 pages

File Size : 42,91 MB

Release : 2011-06-08

Category : Mathematics

ISBN : 364220192X

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Book Description

Modern statistics deals with large and complex data sets, and consequently with models containing a large number of parameters. This book presents a detailed account of recently developed approaches, including the Lasso and versions of it for various models, boosting methods, undirected graphical modeling, and procedures controlling false positive selections. A special characteristic of the book is that it contains comprehensive mathematical theory on high-dimensional statistics combined with methodology, algorithms and illustrations with real data examples. This in-depth approach highlights the methods’ great potential and practical applicability in a variety of settings. As such, it is a valuable resource for researchers, graduate students and experts in statistics, applied mathematics and computer science.



Plant Metabolomics

Author : Kazuki Saito

Publisher : Springer Science & Business Media

Page : 351 pages

File Size : 10,29 MB

Release : 2006-06-29

Category : Science

ISBN : 3540297820

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Book Description

Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.



Mitochondria and Cancer

Author : Keshav Singh

Publisher : Springer Science & Business Media

Page : 294 pages

File Size : 34,25 MB

Release : 2009-04-05

Category : Medical

ISBN : 0387848355

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Book Description

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.



Cancer Chemotherapy and Biotherapy

Author : Bruce A. Chabner

Publisher : Lippincott Williams & Wilkins

Page : 836 pages

File Size : 42,26 MB

Release : 2011-12-07

Category : Medical

ISBN : 1451148208

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Book Description

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.