Cyclic Nucleotide Signaling
Author : Xiaodong C. Cheng
Publisher : CRC Press
Page : 264 pages
File Size : 35,12 MB
Release : 2015
Category : Cellular signal transduction
ISBN :
Author : Xiaodong C. Cheng
Publisher : CRC Press
Page : 264 pages
File Size : 35,12 MB
Release : 2015
Category : Cellular signal transduction
ISBN :
Author : Thomas Brand
Publisher : MDPI
Page : 307 pages
File Size : 50,8 MB
Release : 2018-07-10
Category : Medical
ISBN : 3038429899
This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD
Author : Viacheslav Nikolaev
Publisher : Springer
Page : 383 pages
File Size : 49,44 MB
Release : 2017-09-19
Category : Medical
ISBN : 3319545795
The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.
Author : Thomas Brand
Publisher :
Page : pages
File Size : 13,78 MB
Release : 2018
Category :
ISBN : 9783038429906
Cyclic Nucleotide Signaling and the Cardiovascular System.
Author : Joseph A. Beavo
Publisher : CRC Press
Page : 766 pages
File Size : 44,2 MB
Release : 2006-12-05
Category : Medical
ISBN : 1420020846
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 46,41 MB
Release : 2011
Category : Science
ISBN : 1615041230
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author : Nicholas Sperelakis
Publisher : Elsevier
Page : 1262 pages
File Size : 14,29 MB
Release : 2012-12-02
Category : Science
ISBN : 0080574556
This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
Author : Stephen Waxman
Publisher : Elsevier
Page : 549 pages
File Size : 41,7 MB
Release : 2004-11-05
Category : Medical
ISBN : 0080506984
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson's disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.* Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work* Explores the future of this field
Author : Thomas Brand (Ed.)
Publisher :
Page : pages
File Size : 45,6 MB
Release :
Category :
ISBN :
Author : Michitoshi Inoue
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 45,14 MB
Release : 2013-11-09
Category : Medical
ISBN : 4431683674
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.