Molecular Biology of the Cell
Author :
Publisher :
Page : 0 pages
File Size : 40,94 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
DNA Conformation and Transcription
Author : Takashi Ohyama
Publisher : Springer Science & Business Media
Page : 215 pages
File Size : 34,77 MB
Release : 2007-02-26
Category : Medical
ISBN : 0387291482
Book Description
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century. We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
RNA Polymerases as Molecular Motors
Author : Robert Landick
Publisher : Royal Society of Chemistry
Page : 295 pages
File Size : 22,33 MB
Release : 2021-11-23
Category : Science
ISBN : 1839160667
Book Description
To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.
Modified Nucleic Acids
Author : Kazuhiko Nakatani
Publisher : Springer
Page : 280 pages
File Size : 36,94 MB
Release : 2016-04-04
Category : Science
ISBN : 3319271113
Book Description
This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
DNA Topology
Author : Andrew D. Bates
Publisher : Oxford University Press, USA
Page : 224 pages
File Size : 34,27 MB
Release : 2005
Category : Science
ISBN : 9780198567097
Book Description
"A key aspect of DNA is its ability to form a variety of structures, this book explains the origins and importance of such structures"--Provided by publisher.
Principles of Nucleic Acid Structure
Author : Wolfram Saenger
Publisher : Springer Science & Business Media
Page : 574 pages
File Size : 25,10 MB
Release : 2013-12-01
Category : Science
ISBN : 1461251907
Book Description
New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.
DNA Structure and Function
Author : Richard R. Sinden
Publisher : Elsevier
Page : 423 pages
File Size : 49,89 MB
Release : 2012-12-02
Category : Science
ISBN : 0080571735
Book Description
DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics. - Explains basic DNA Structure and function clearly and simply - Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations - Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure - Highlights key experiments and ideas within boxed sections - Illustrated with 150 diagrams and figures that convey structural and experimental concepts
Protein Dimerization and Oligomerization in Biology
Author : Jacqueline M. Matthews
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 15,97 MB
Release : 2012-09-04
Category : Medical
ISBN : 1461432294
Book Description
This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.
Topology and Physics of Circular DNA (1992)
Author : Alexander Vologodskii
Publisher : CRC Press
Page : 303 pages
File Size : 44,79 MB
Release : 2017-11-22
Category : Medical
ISBN : 1351355821
Book Description
Topology and Physics of Circular DNA presents comprehensive coverage of the physical properties of circular DNA. The author examines how topological constraints arising from cyclization of DNA lead to distinctive properties that make closed molecules radically different from linear DNA. The phenomenon of supercoiling, its geometric and topological analysis, and the formation of noncanonical structures in circular DNA under the influence of supercoiling are emphasized. The combination of consistent theoretical analysis and detailed treatment of major experimental approaches make Topology and Physics of Circular DNA an important reference volume for biophysicists, biochemists, molecular biologists, and researchers and students who want to expand their understanding of circular DNA.
Epigenetics and Regeneration
Author :
Publisher : Academic Press
Page : 544 pages
File Size : 43,49 MB
Release : 2019-05-24
Category : Science
ISBN : 0128148802
Book Description
Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. - Provides a foundational overview of epigenetics in regenerative medicine - Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice - Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways - Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine
