Doing Integrated History and Philosophy of Science: A Case Study of the Origin of Genetics


Book Description

This book offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. This book consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice. Part I lays out a new historiography, serving as a basis for the discussions in part II and part III. Part II introduces a new integrated HPS method to analyse and interpret the historiography in Part I and to re-examine the philosophical issues in Part III. Part III develops new philosophical accounts which will in turn make a better sense of the history of scientific practice more generally. This book provides a practical defence of integrated HPS: the best way to defend integrated HPS is to do it.




Genetics and Reductionism


Book Description

With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something 'genetic'? This is the fundamental question that Sahotra Sarkar's book addresses. The author analyses the nature of reductionism in classical and molecular genetics. He shows that there are two radically different kinds of reductionist explanation: genetic reduction (as found in classical genetics) and physical reduction (found in molecular genetics). This important book clarifies the meaning of the term 'genetic', shows how molecular studies have affected genetics, and provides the philosophical background necessary to understand the debates over the Human Genome Project. It will be of particular interest to professionals and students in the philosophy of science, the history of science, and the social studies of science, medicine, and technology.




Genetic Analysis


Book Description

There is a paradox lying at the heart of the study of heredity. To understand the ways in which features are passed on down from one generation to the next, we have to dig deeper and deeper into the ultimate nature of things - from organisms, to genes, to molecules. And yet as we do this, increasingly we find we are out of focus with our subjects. What has any of this to do with the living, breathing organisms with which we started? Organisms are living. Molecules are not. How do we relate one to the other? In Genetic Analysis, one of the most important empirical scientists in the field in the twentieth century attempts, through a study of history and drawing on his own vast experience as a practitioner, to face this paradox head-on. His book offers a deep and innovative understanding of our ways of thinking about heredity.




Philosophy and Revolutions in Genetics


Book Description

The last century saw two great revolutions in genetics; the development of classic Mendelian theory and the discovery and investigation of DNA. Each fundamental scientific discovery in turn generated its own distinctive technology. Biotechnology is the offspring of the latter and is expected to be the driving force behind economic growth in the twenty-first century. These two case studies enable the author to conduct a philosophical exploration of the relationship between fundamental scientific discoveries on the one hand, and the technologies that spring from them on the other. As such it is also an exercise in the philosophy of technology.




Genetics and Philosophy


Book Description

In the past century, nearly all of the biological sciences have been directly affected by discoveries and developments in genetics, a fast-evolving subject with important theoretical dimensions. In this rich and accessible book, Paul Griffiths and Karola Stotz show how the concept of the gene has evolved and diversified across the many fields that make up modern biology. By examining the molecular biology of the 'environment', they situate genetics in the developmental biology of whole organisms, and reveal how the molecular biosciences have undermined the nature/nurture distinction. Their discussion gives full weight to the revolutionary impacts of molecular biology, while rejecting 'genocentrism' and 'reductionism', and brings the topic right up to date with the philosophical implications of the most recent developments in genetics. Their book will be invaluable for those studying the philosophy of biology, genetics and other life sciences.




New Philosophical Perspectives on Scientific Progress


Book Description

This collection of original essays offers a comprehensive examination of scientific progress, which has been a central topic in recent debates in philosophy of science. Traditionally, debates over scientific progress have focused on different methodological approaches, notably the epistemic and semantic approaches. The chapters in Part I of the book examine these two traditional approaches, as well as the newly revived functional and newly developed noetic approaches. Part II features in-depth case studies of scientific progress from the history of science. The chapters cover individual sciences including physics, chemistry, evolutionary biology, seismology, psychology, sociology, economics, and medicine. Finally, Part III of the book explores important issues from contemporary philosophy of science. These chapters address the implications of scientific progress for the scientific realism/anti-realism debate, incommensurability, values in science, idealisation, scientific speculation, interdisciplinarity, and scientific perspectivalism. New Philosophical Perspectives on Scientific Progress will be of interest to researchers and advanced students working on the history and philosophy of science.




The Concept of the Gene in Development and Evolution


Book Description

Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as a focal point of interdisciplinary and international research. It will be of interest to professionals and students in the philosophy and history of science, genetics and molecular biology.




Understanding Origins


Book Description

The main intention of this book is to bring together contributions from biology, cognitive science, and the humanities for a joint exploration of some of the main contemporary notions dealing with the understanding of origins in life,mind and society. The question of origin is inseparable from a web of hypotheses that both shape and explain us. Although origin invites examination, it always seems to elude our grasp. Notions have always been produced to interpret the genesis of life, mind, and the social order, and these notions have all remained unstable in the face of theoretical and empirical challenges. In any given period, the central ideas on origin have had a mutual resonance frequently overlooked by specialists engaged in theirown particular fields. As a consequence, this book should be of interest to a wide audi ence. In particular, for all those engaged in the social sciences and the philosophy of science, it is unique document, since bridges to the natural sciences in a mutually illuminating way are hard to find. Whether as a primary source or as inspirational reading, we feel this book has a place in every library. The material comes from an international meeting held in September 13-16, 1987 at Stanford University, organized by F. Varela and J.-P. Dupuy at the request of the Program of Interdisciplinary Research of Stanford University. We are grateful to Rene Girard, the Program Director, for making it possible with the help of the Mellon Foundation.




The Logic of Life


Book Description

In "The Logic of Life" Francois Jacob looks at the way our understanding of biology has changed since the sixteenth century. He describes four fundamental turning points in the perception of the structure of living things: the discoveries of the functions of organs, cells, chromosomes and genes, and DNA.




Mendel's Legacy


Book Description

This latest book by Elof Carlson (The Unfit) is a first history of classical genetics, the era in which the chromosome theory of heredity was proposed and developed. Highly illustrated and based heavily on early 20th century original sources, the book traces the roots of genetics in breeding analysis and studies of cytology, evolution, and reproductive biology that began in Europe but were synthesized in the United States through new Ph.D. programs and expanded academic funding. Carlson argues that, influenced largely by new technologies and instrumentation, the life sciences progressed though incremental change rather than paradigm shifts, and he describes how molecular biology emerged from the key ideas and model systems of classical genetics. Readable and original, this narrative will interest historians and science educators as well as today's practitioners of genetics.