Dynamical System Models In The Life Sciences And Their Underlying Scientific Issues


Book Description

Broadly speaking, there are two general approaches to teaching mathematical modeling: 1) the case study approach, and 2) the method based approach (that teaches mathematical techniques with applications to relevant mathematical models). This text emphasizes instead the scientific issues for modeling different phenomena. For the natural or harvested growth of a fish population, we may be interested in the evolution of the population, whether it reaches a steady state (equilibrium or cycle), stable or unstable with respect to a small perturbation from equilibrium, or whether a small change in the environment would cause a catastrophic change, etc. Each scientific issue requires an appropriate model and a different set of mathematical tools to extract information from the model. Models examined are chosen to help explain or justify empirical observations such as cocktail drug treatments are more effective and regenerations after injuries or illness are fast-tracked (compared to original developments).Volume I of this three-volume set limits its scope to phenomena and scientific issues that are modeled by ordinary differential equations (ODE). Scientific issues such as signal and wave propagation, diffusion, and shock formation involving spatial dynamics to be modeled by partial differential equations (PDE) will be treated in Vol. II. Scientific issues involving randomness and uncertainty are examined in Vol. III.




Stochastic Models In The Life Sciences And Their Methods Of Analysis


Book Description

'… the volume is impressively accessible. The result is a book that is valuable and approachable for biologists at all levels, including those interested in deepening their skills in mathematical modeling and those who seek an overview to aid them in communicating with collaborators in mathematics and statistics. The former group of readers may especially appreciate the first chapter, an introduction to key concepts in probability, and the set of ten assignments provided as an appendix.'CHOICEBiological processes are evolutionary in nature and often evolve in a noisy environment or in the presence of uncertainty. Such evolving phenomena are necessarily modeled mathematically by stochastic differential/difference equations (SDE), which have been recognized as essential for a true understanding of many biological phenomena. Yet, there is a dearth of teaching material in this area for interested students and researchers, notwithstanding the addition of some recent texts on stochastic modelling in the life sciences. The reason may well be the demanding mathematical pre-requisites needed to 'solve' SDE.A principal goal of this volume is to provide a working knowledge of SDE based on the premise that familiarity with the basic elements of a stochastic calculus for random processes is unavoidable. Through some SDE models of familiar biological phenomena, we show how stochastic methods developed for other areas of science and engineering are also useful in the life sciences. In the process, the volume introduces to biologists a collection of analytical and computational methods for research and applications in this emerging area of life science. The additions broaden the available tools for SDE models for biologists that have been limited by and large to stochastic simulations.




Spatial Dynamics Models In The Life Sciences And The Role Of Feedback In Robust Developments


Book Description

Basic mathematical techniques for partial differential equations (PDE) with applications to the life sciences form an integral part of the core curriculum for programs in mathematical biology. Yet, students in such a program with an undergraduate training in biology are typically deficient in any exposure to PDE. This volume starts with simple first order PDE and progresses through higher order equations and systems but with interesting applications, even at the level of a single first order PDE with constant coefficients.Similar to the two previous volumes by the author, another unique feature of the book is highlighting the scientific theme(s) of interest for the biological phenomena being modelled and analysed. In addition to temporal evolution of a biological phenomenon, its limiting equilibrium states and their stability, the possibility of locational variations leads to a study of additional themes such as (signal and wave) propagation, spatial patterning and robustness. The requirement that biological developments are relatively insensitive to sustained environmental changes provides an opportunity to examine the issue of feedback and robustness not encountered in the previous two volumes of this series.




Modeling Life


Book Description

This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?




Dynamical Models of Biology and Medicine


Book Description

Mathematical and computational modeling approaches in biological and medical research are experiencing rapid growth globally. This Special Issue Book intends to scratch the surface of this exciting phenomenon. The subject areas covered involve general mathematical methods and their applications in biology and medicine, with an emphasis on work related to mathematical and computational modeling of the complex dynamics observed in biological and medical research. Fourteen rigorously reviewed papers were included in this Special Issue. These papers cover several timely topics relating to classical population biology, fundamental biology, and modern medicine. While the authors of these papers dealt with very different modeling questions, they were all motivated by specific applications in biology and medicine and employed innovative mathematical and computational methods to study the complex dynamics of their models. We hope that these papers detail case studies that will inspire many additional mathematical modeling efforts in biology and medicine




A Framework for K-12 Science Education


Book Description

Science, engineering, and technology permeate nearly every facet of modern life and hold the key to solving many of humanity's most pressing current and future challenges. The United States' position in the global economy is declining, in part because U.S. workers lack fundamental knowledge in these fields. To address the critical issues of U.S. competitiveness and to better prepare the workforce, A Framework for K-12 Science Education proposes a new approach to K-12 science education that will capture students' interest and provide them with the necessary foundational knowledge in the field. A Framework for K-12 Science Education outlines a broad set of expectations for students in science and engineering in grades K-12. These expectations will inform the development of new standards for K-12 science education and, subsequently, revisions to curriculum, instruction, assessment, and professional development for educators. This book identifies three dimensions that convey the core ideas and practices around which science and engineering education in these grades should be built. These three dimensions are: crosscutting concepts that unify the study of science through their common application across science and engineering; scientific and engineering practices; and disciplinary core ideas in the physical sciences, life sciences, and earth and space sciences and for engineering, technology, and the applications of science. The overarching goal is for all high school graduates to have sufficient knowledge of science and engineering to engage in public discussions on science-related issues, be careful consumers of scientific and technical information, and enter the careers of their choice. A Framework for K-12 Science Education is the first step in a process that can inform state-level decisions and achieve a research-grounded basis for improving science instruction and learning across the country. The book will guide standards developers, teachers, curriculum designers, assessment developers, state and district science administrators, and educators who teach science in informal environments.




Dynamic Models in Biology


Book Description

From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering.




Mathematical Modeling for the Life Sciences


Book Description

Provides a wide range of mathematical models currently used in the life sciences Each model is thoroughly explained and illustrated by example Includes three appendices to allow for independent reading




Handbook of Child Psychology and Developmental Science, Theory and Method


Book Description

The essential reference for human development theory, updated and reconceptualized The Handbook of Child Psychology and Developmental Science, a four-volume reference, is the field-defining work to which all others are compared. First published in 1946, and now in its Seventh Edition, the Handbook has long been considered the definitive guide to the field of developmental science. Volume 1, Theory and Method, presents a rich mix of classic and contemporary theoretical perspectives, but the dominant views throughout are marked by an emphasis on the dynamic interplay of all facets of the developmental system across the life span, incorporating the range of biological, cognitive, emotional, social, cultural, and ecological levels of analysis. Examples of the theoretical approaches discussed in the volume include those pertinent to human evolution, self regulation, the development of dynamic skills, and positive youth development. The research, methodological, and applied implications of the theoretical models discussed in the volume are presented. Understand the contributions of biology, person, and context to development within the embodied ecological system Discover the relations among individual, the social world, culture, and history that constitute human development Examine the methods of dynamic, developmental research Learn person-oriented methodological approaches to assessing developmental change The scholarship within this volume and, as well, across the four volumes of this edition, illustrate that developmental science is in the midst of a very exciting period. There is a paradigm shift that involves increasingly greater understanding of how to describe, explain, and optimize the course of human life for diverse individuals living within diverse contexts. This Handbook is the definitive reference for educators, policy-makers, researchers, students, and practitioners in human development, psychology, sociology, anthropology, and neuroscience.




Handbook of Dynamic System Modeling


Book Description

The topic of dynamic models tends to be splintered across various disciplines, making it difficult to uniformly study the subject. Moreover, the models have a variety of representations, from traditional mathematical notations to diagrammatic and immersive depictions. Collecting all of these expressions of dynamic models, the Handbook of Dynamic Sy