Janeway's Immunobiology


Book Description

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.




Dynamics of Immune Activation in Viral Diseases


Book Description

This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.




Persistent Viral Infections


Book Description

Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.




Dynamics of Immune Activation in Viral Diseases


Book Description

This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.




Treating Infectious Diseases in a Microbial World


Book Description

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.




Primary HIV Infection


Book Description







Immunopathogenesis of HIV Infection


Book Description

During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.




Virus Dynamics : Mathematical Principles of Immunology and Virology


Book Description

This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature




The Autoimmune Brain


Book Description

There are millions of people who experience issues related to brain health—depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain—yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or anti-anxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age—from children to teens or seniors—people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. The Autoimmune Brain connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer’s disease; Anxiety; Arthritis; Autism; Autonomic disturbances; Bacterial and viral infections; Bipolar Disorder; Cancer; Celiac disease and gluten intolerances; Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease); Chronic Pain; Dementia; Depression; Endocrine Disorders; Immune modulatory therapy using IVIg; Lyme disease and co-infections; Mast cell activation syndrome; Medical cannabis; Obsessive Compulsive Disorder; Orthostatic hypotension; Peripheral Neuropathy; Porphyria; Post-Traumatic Stress Disorder; and Postural orthostatic tachycardia.