The Mechanism of Antimicrobial Action of Electro-chemically Activated (ECA) Water and Its Healthcare Applications


Book Description

The Electrochemical Activation (ECA) of water is introduced as a novel refinement of conventional electrochemical processes and the unique features and attributes are evaluated against the universal principles that have described the electrolytic processes to date. While the novel and patented novel reactor design retains the capacity to generate products common to conventional electrolysis, it also manipulates the properties of the reagent solutions to achieve an anomalous Oxidation-Reduction potential (ORP or REDOX) that cannot be replicated by traditional chemical and physical interventions. As a contemporary development in the field, the technology continues to undergo rigorous assessment and while not all of its theoretical aspects have been exhaustively interrogated, its undisputed biocidal efficacy has been widely established. Microbial vitality has been shown to be directly dependent upon the confluence of a diverse variety of physical and chemical environmental conditions. Fundamentally important in this regard is the electronic balance or REDOX potential of the microbial environment. The intricate balance of metabolic pathways that maintain cellular integrity underwrites the measures of irritability required for sustained viability. Aside from the direct effects of the conventional electrolysis products, overt electronic disruption of the immediate microbial environment initiates a cascade of secondary and largely independent autocidal molecular events which compromise the fundamental integrity of the microbe and leads to cell death. The distinctive capacity to impart unique physicochemical attributes to the ECA derived solutions also facilitates the characterisation of the same outside of the conventional physicochemical and gravimetric measures. These adjunct measures display a substantial relationship with the predictability of antimicrobial effect, and the direct relationship between inactivation of a defined microbial bioload and the titratable measures of REDOX capacity have been shown to describe a repeatable benchmark. The use of ultra-microscopy to investigate the impact of the ECA products on bacterial cell structures has shown this tool to have distinctive merit in the imaging and thus refined description of the consequences of exposure to biocidal solutions. The distinctive differences of the ECA solutions relative to conventional antibacterial compounds would suggest a heightened suitability for application in conditions where the efficacy of conventional biocidal compounds had been limited. Aeroslisation of the ECA solutions for the decontamination of airspaces challenged with tuberculosis pathogens revealed that despite initial success, further refinements to the application model will be required to meet the unresolved challenges. The health care benefits associated with the application of the ECA solutions in a medical environment substantiate the merits for the adoption of the technology as a complementary remedy for the management of nosocomial infections. The relative novelty of the technology in the commercial domain will raise questions regarding the potential for resistance development, and it has been proposed that the distinctive mechanism of biocidal action will not contribute to diminished bacterial susceptibility, as it does not reveal any cross- or co-resistance when assessed against multiple antibiotic resistant strains. These benefits are further reinforced by the capacity to install the technology for both onsite and on-demand availability, and being derived from natural ingredients (salt and water) the ECA solutions are regarded as safe and compatible for general in-contact use. Notwithstanding the multiple benefits that the technology may provide, further assessments into materials compatibility as well as potential by-products formation following environmental exposure are imperative before the unfettered adoption of this technology as a cost-effective, safe and reliable alternative to conventional disinfection can be promoted.







Disinfection, Sterilization, and Preservation


Book Description

This new edition is a comprehensive, practical reference on contemporary methods of disinfection, sterlization, and preservation and their medical, surgical, and public health applications. New topics covered include recently identified pathogens, microbial biofilms, use of antibiotics as antiseptics, synergism between chemical microbicides, pulsed-light sterilization of pharmaceuticals, and new methods for medical waste management. (Midwest).




Textbook of Endodontics


Book Description

Endodontics is the prevention, diagnosis and management of diseases of the tooth pulp and the tissues surrounding the root of a tooth. This new edition is a complete guide to endodontics for dental students. Divided into 39 chapters, the book covers numerous procedures and case studies and the text is further enhanced by more than 1500 clinical photographs, diagrams and tables. The fourth edition has been fully revised, and new topics added, to provide students with the latest information and advances in the field. Key points and clinical tips are highlighted for each topic and questions are included at the end of each chapter to assist exam preparation. Key points Complete guide to endodontics for dental students Fully revised, new edition providing latest advances in the field Includes more than 1500 clinical photographs, diagrams and tables Previous edition (9789350909522) published in 2013




Handbook of Food Processing


Book Description

Packed with case studies and problem calculations, Handbook of Food Processing: Food Safety, Quality, and Manufacturing Processes presents the information necessary to design food processing operations and describes the equipment needed to carry them out in detail. It covers the most common and new food manufacturing processes while addressing rele




Handbook of Food Processing, Two Volume Set


Book Description

Authored by world experts, the Handbook of Food Processing, Two-Volume Set discusses the basic principles and applications of major commercial food processing technologies. The handbook discusses food preservation processes, including blanching, pasteurization, chilling, freezing, aseptic packaging, and non-thermal food processing. It describes com




Pulp and Paper Industry


Book Description

Pulp and Paper Industry: Microbiological Issues in Papermaking features in-depth and thorough coverage of microbiological issues in papermaking and their consequences and the current state of the different alternatives for prevention, treatment and control of biofilm/slime considering the impact of the actual technological changes in papermaking on the control programmes. The microbial issues in paper mill systems, chemistry of deposits on paper machines, the strategies for deposit control and methods used for the analysis of biofouling are all dealt in this book along with various growth prevention methods. The traditional use of biocides is discussed taken into account the new environmental regulations regarding their use. Finally, discusses the trends regarding the future of the microbiological control in papermaking systems. - In-depth coverage of microbiological issues in papermaking and their consequences - Discusses eco-efficient processes (green processes) for biofilm/slime control - Offers a thorough review of the current literature with links to the primary literature - Comprehensive indexing - Author is an authority in the pulp and paper industry




Materials Used in Dentistry


Book Description

The fully revised and updated second edition of “Materials Used in Dentistry” discusses all the relevant topics, properties, and clinical applications of the most common dental materials in simple, concise, and coherent manner. It includes numerous photographs, illustrations, flowcharts, and tables to make the presentation simple and student friendly.