A Handbook for DNA-Encoded Chemistry


Book Description

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods




Healthcare as a Human Rights Issue


Book Description

This book deals with various facets of the human right to health: its normative profile as a universal right, current political and legal conflicts and contextualized implementation in different healthcare systems. The authors come from different countries and disciplines - law, political science, ethics, medicine etc. - and bring together a broad variety of academic and practical perspectives. The volume contains selected contributions of the international conference "The Right to Health - an Empty Promise?" held in September 2015 in Berlin and organized by the Emerging Field Initiative Project "Human Rights in Healthcare" (University of Erlangen-Nürnberg).




One Billion Hungry


Book Description

Hunger is a daily reality for a billion people. More than six decades after the technological discoveries that led to the Green Revolution aimed at ending world hunger, regular food shortages, malnutrition, and poverty still plague vast swaths of the world. And with increasing food prices, climate change, resource inequality, and an ever-increasing global population, the future holds further challenges.In One Billion Hungry, Sir Gordon Conway, one of the world's foremost experts on global food needs, explains the many interrelated issues critical to our global food supply from the science of agricultural advances to the politics of food security. He expands the discussion begun in his influential The Doubly Green Revolution: Food for All in the Twenty-First Century, emphasizing the essential combination of increased food production, environmental stability, and poverty reduction necessary to end endemic hunger on our planet. Conway addresses a series of urgent questions about global hunger: • How we will feed a growing global population in the face of a wide range of adverse factors, including climate change? • What contributions can the social and natural sciences make in finding solutions?• And how can we engage both government and the private sector to apply these solutions and achieve significant impact in the lives of the poor?Conway succeeds in sharing his informed optimism about our collective ability to address these fundamental challenges if we use technology paired with sustainable practices and strategic planning.Beginning with a definition of hunger and how it is calculated, and moving through issues topically both detailed and comprehensive, each chapter focuses on specific challenges and solutions, ranging in scope from the farmer's daily life to the global movement of food, money, and ideas. Drawing on the latest scientific research and the results of projects around the world, Conway addresses the concepts and realities of our global food needs: the legacy of the Green Revolution; the impact of market forces on food availability; the promise and perils of genetically modified foods; agricultural innovation in regard to crops, livestock, pest control, soil, and water; and the need to both adapt to and slow the rate of climate change. One Billion Hungry will be welcomed by all readers seeking a multifaceted understanding of our global food supply, food security, international agricultural development, and sustainability.




Bridging Cultural Concepts of Nature


Book Description

National parks and other preserved spaces of nature have become iconic symbols of nature protection around the world. However, the worldviews of Indigenous peoples have been marginalized in discourses of nature preservation and conservation. As a result, for generations of Indigenous peoples, these protected spaces of nature have meant dispossession, treaty violations of hunting and fishing rights, and the loss of sacred places. Bridging Cultural Concepts of Nature brings together anthropologists and archaeologists, historians, linguists, policy experts, and communications scholars to discuss differing views and presents a compelling case for the possibility of more productive discussions on the environment, sustainability, and nature protection. Drawing on case studies from Scandinavia to Latin America and from North America to New Zealand, the volume challenges the old paradigm where Indigenous peoples are not included in the conservation and protection of natural areas and instead calls for the incorporation of Indigenous voices into this debate. This original and timely edited collection offers a global perspective on the social, cultural, economic, and environmental challenges facing Indigenous peoples and their governmental and NGO counterparts in the co-management of the planet’s vital and precious preserved spaces of nature.




Indigenous Peoples, Poverty, and Development


Book Description

This is the first book that documents poverty systematically for the world's indigenous peoples in developing regions in Asia, Africa, and Latin America. The volume compiles results for roughly 85 percent of the world's indigenous peoples. It draws on nationally representative data to compare trends in countries' poverty rates and other social indicators with those for indigenous sub-populations and provides comparable data for a wide range of countries all over the world. It estimates global poverty numbers and analyzes other important development indicators, such as schooling, health, and social protection. Provocatively, the results show a marked difference in results across regions, with rapid poverty reduction among indigenous (and non-indigenous) populations in Asia contrasting with relative stagnation - and in some cases falling back - in Latin America and Africa. Two main factors motivate the book. First, there is a growing concern among poverty analysts worldwide that countries with significant vulnerable populations - such as indigenous peoples - may not meet the Millennium Development Goals, and thus there exists a consequent need for better data tracking conditions among these groups. Second, there is a growing call by indigenous organizations, including the United Nations Permanent Forum on Indigenous Peoples, for solid, disaggregated data analyzing the size and causes of the "development gap."







The Human Right to Health (Norton Global Ethics Series)


Book Description

“A broad-ranging, insightful analysis of the complex practical and ethical issues involved in global health.”—Kirkus Reviews Few topics in human rights have inspired as much debate as the right to health. Proponents would enshrine it as a fundamental right on a par with freedom of speech and freedom from torture. Detractors suggest that the movement constitutes an impractical over-reach. Jonathan Wolff cuts through the ideological stalemate to explore both views. In an accessible, persuasive voice, he explores the philosophical underpinnings of the idea of a human right, assesses whether health meets those criteria, and identifies the political and cultural realities we face in attempts to improve the health of citizens in wildly different regions. Wolff ultimately finds that there is a path forward for proponents of the right to health, but to succeed they must embrace certain intellectual and practical changes. The Human Right to Health is a powerful and important contribution to the discourse on global health.




Health and Human Rights


Book Description

This collection serves as an introduction to the new and emerging field of health and human rights. It covers such timely subjects as cleansing, world population control, women's reproductive choices, AIDS and HIV.




Clinical Decision Support Systems


Book Description

Written by nationally and internationally recognised experts on the design, evaluation and application of such systems, this book examines the impact of practitioner and patient use of computer-based diagnostic tools. It serves simultaneously as a resource book on diagnostic systems for informatics specialists; a textbook for teachers or students in health or medical informatics training programs; and as a comprehensive introduction for clinicians, with or without expertise in the applications of computers in medicine, who are interested in learning about current developments in computer-based diagnostic systems. Designed for a broad range of clinicians in need of decision support.