Author : Holger Schmid-Schönbein
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 26,12 MB
Release : 1984-12-31
Category : Medical
ISBN : 9780898387049
Proceedings of an interdisciplinary meeting, sponsored by the Commission of the European Communities, as advised by the Committee on Medical and Public Health Research
Author : Roland N. Pittman
Publisher : Biota Publishing
Page : 117 pages
File Size : 28,52 MB
Release : 2016-08-18
Category : Medical
ISBN : 1615047212
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Author : C.Th. Smit Sibinga
Publisher : Springer Science & Business Media
Page : 297 pages
File Size : 10,23 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461315158
The theme of this 14th International Symposium on Blood Transfusion is closely related to the work and scientific contributions of the Dutch cryobiology pioneer Dr. Herman W. Krijnen of the Dutch Red Cross Central Laboratory. Dr. Krijnen was known and respected in the national and interna tional blood transfusion community as an extremely competent scientist and a beloved and admired colleague. Dr. Krijnen was intentionally honoured with the invitation to open this symposium on cryopreservation and low temperature biology in blood transfusion and be the guest of honour at this event. Unfortunately, Dr. Krijnen suddenly died on the first of June 1989. In honour and mem ory of Dr. Krijnen this symposium will therefore be dedicated to him. Since the lOth International Symposium on Blood Transfusion in 1985 highlighted the theme of "Future developments in blood banking", major changes have occurred in the blood banking world. Most of these changes were forced upon the Blood Banks by the fear of spreading AIDS through contaminated donations. This not only led to the wide spread testing of blood, but also to a more appropriate counselling of the community and the blood donors in specific. Additionally, virus inacti vation techniques were introduced for those components derived from multiple donations and intended for a regular transfusion in haemophi lia patients and others.
Author : C.Th. Smit Sibinga
Publisher : Springer Science & Business Media
Page : 229 pages
File Size : 43,81 MB
Release : 2013-11-11
Category : Medical
ISBN : 1475720270
With this symposium the Red Cross Blood Bank Groningen-Drenthe affirms its well known reputation as an organizer of symposia of high standard and quality. Several important aspects of bloodbanking have been discussed in the past. The Blood Bank here is a specialist in its own field. Administrative processes in respect of the donor, information processes, the preparation of the blood and the laboratory process are automatized. New developments in these fields are undeway that you will certainly identify and investigate. I do hope that you will come to conclusions from which we can learn and get better results. As general manager of the Development and Investments Company for the Northern Netherlands - NOM - for several reasons I am very much interested in the outcome of this symposium. In the first place I am proud that the Red Cross Blood Bank Groningen Drenthe is doing its utmost to be excellent in regard of research, education and bloodprocessing. In being so, the Blood Bank can produce spinn-offs for healthservices and the related industry.
Author :
Publisher :
Page : 760 pages
File Size : 33,73 MB
Release : 2002
Category : Artificial organs
ISBN :
Author : The Commission of the European Communities & UNEP, ILO, WHO International Programme on Chemical Safety
Publisher : Springer Science & Business Media
Page : 538 pages
File Size : 11,98 MB
Release : 1987-02-28
Category : Medical
ISBN : 9780898388435
IX The International Seminar on the Immunological System as a Target for Toxic Damage was held at The Commission of the European Communities (CEC) in Luxembourg on 6-9 November 1984. It was organized by the CEC and the International Programme on Chemical Safety of UNEP/ILO/WHO with the support of the u. S. Environmental Protection Agency and the National Institute of Environmental Health Sciences - USA and with the participation of the International Society of Immunophar macology. These bodies are actively concerned with the scientific and applied aspects of immunotoxicology. The Seminar consisted of thirty-four invited papers and three major panel discussions covering current and future test strategies for the screening of immunotoxic substances, hypersensitivity and the health implications of immunotoxico logical problems. It was attended by more than 200 scien tists from 27 countries representing all the Member states of the European Economic Community and the six Regions of the World Health Organization. These scientists represented many different disciplines and interests. The Seminar's principal objectives were: a review of recent advances in knowledge concerning the structure, function and dysfunction of the immunological system; - a review of the effects of xenobiotics on the immune system in animals and humans; an examination of the human health implications of immunotoxicity; discussion and critical analysis of the procedures for the assessment of immunological damage, a discussion of needs for the further development of laboratory and epidemiological methods and their validation, and a consideration of current test strategies.
Author : N. Friedel
Publisher : Springer Science & Business Media
Page : 317 pages
File Size : 32,12 MB
Release : 2013-06-29
Category : Medical
ISBN : 3662061198
Cardiac surgery has developed dramatically since the first open-he art operations were performed in the mid 1950s. Although the improvement of surgical technique, extracorporeal circulation, and postoperative management has contributed to a marked reduction of morbidity and mortality, the development of cardiac surgery to its present state would not have been possible without blood substitution by homologous donor blood. Only 20 years ago, open-heart operations required an average of 8 units of blood preserves. The excessive need of donor blood in those early days was mainly due to premature surgical technique, insecure control of anticoagulation, severe blood trauma by extracorporeal circulation, and the lack of retransfusion technologies that would have allowed the reuse of shed mediastinal blood. The introduction of new technologies, such as normovolemic hemodilution, in traoperative autotransfusion, postoperative return of shed mediastinal blood, and predonation of autologous blood has greatly reduced donor blood requirements. At present the majority of routine coronary artery surgical procedures can be performed without any blood transfusion. Blood loss, however, may be considerable in patients undergoing complex valve surgery or reoperations, as they often require several units of transfused blood. Blood conservation has now become an area of major interest for the cardiac surgeon. This increased concern is caused by infectious complications of blood transfusion, in particular hepatitis and, more recently, AIDS.
Author : Cees Smit Sibinga
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 32,59 MB
Release : 2002-09-30
Category : Medical
ISBN : 9781402009860
This book is the only published literature that comprehensively discusses all aspects of transfusion of transmissible diseases, the facts and the fiction. It is of paramount importance to all involved in the vein to vein chain of transfusion medicine. Transmissible Diseases and Blood Transfusion is an important reference for all hematologists and researchers involved in transfusion medicine.
Author : Cees Smit Sibinga
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 10,82 MB
Release : 1998-09-30
Category : Medical
ISBN : 9780792383055
Currently blood is a volatile issue. The safety of blood and the quantification of transfusion risks have been dominant themes that have stimulated the development of alternative approaches in this rapidly developing area. In clinical medicine conventional blood and its components are used in supportive therapies dependent on the choice of apparent uncritical trigger factors. A compounding factor is depth of prospective clinical trials for evidence. Such trials in critical care areas would be of enormous value, not only in recording adverse effects and under-transfusion, but also indicating the value of decision analysis and cost-effectiveness in transfusion practice. Alternative approaches include the use of cytokines, growth factors, humanised monoclonal antibodies, recombinant plasma factors, and buffy coat derived natural human interferons. These are being increasingly implemented in the clinic. Solutions for oxygen transport are being developed and fibrinogen coated microcapsules are being investigated for thrombocytopenia. In surgical patients, various crystalloid and colloid combinations are explored as volume replacements. To avoid allogeneic transfusions, beneficial blood saving methods include various strategies, such as autologous deposits, normovolemic haemodilution and various agents including aprotinin, tranecamic acid, desmopressin and erythropoietin, but their use in hospital shows considerable variations. That umbilical cord blood could be a significant source of allogeneic stem cells in related and unrelated transplantation is illustrated by the increasing number of cord blood banks in Europe and elsewhere. Future blood resources are likely to face several challenges: immediate challenges relate to increased regulatory and political oversights; intermediate solutions would offer some improvements in public health and alleviate public fear but probably not address the economic challenges thrust upon the medical care system. As we approach the year 2000, the major concerns about transfusion medicine remain its logistics, safety and effectiveness. This theme is presented in the proceedings of the 22nd International Symposium on Blood Transfusion, developed in 21 up-to-date topics, collected and discussed in four sections. This book will be of timely value to students, professionals and all others interested or involved in the field of transfusion medicine, whether clinical or related.
Author : Cees Smit Sibinga
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 39,90 MB
Release : 2000-09-30
Category : Medical
ISBN : 9780792365341
The international symposia on blood transfusion in Groningen have taken place without interruption since 1976. Each year Dr. Smit-Sibinga and his team have not only organized a meeting on timely topics in blood transfusion, but also succeeded in attracting prominent chairmen and speakers. The subject of the 24th Symposium was Molecular Biology in Blood Transfusion and it was chaired by Dr. Harvey G. Klein, National Institutes of Health, USA. In this book of proceedings an extraordinary range of subjects is covered, including diagnostic aspects, virology, quality control, cell and protein processing as well as a section on new horizons in clinical medicine.
