Inhibitory Synaptic Plasticity


Book Description

This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.




Excitation and Inhibition


Book Description




Excitatory-Inhibitory Balance


Book Description

A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition. A recent surge in research activity focused on inhibitory interneurons now makes a more balanced view possible. Technological advances such as improved imaging methods, visualized patch-clamp recording, multiplex single-cell PCR, and gene-targeted deletion or knock-in mice are some of the novel tools featured in this book. This book will provide an integrated view of neuron function, operating in a balanced regime of excitation and inhibition. It is a timely contribution emphasizing how this balance is established, maintained, and modified from the molecular to system levels. The broad spectrum of topics from molecular to cellular and system/computational neuroscience will appeal to a wide audience of advanced graduate students, post-docs, and faculty. Moreover, this book this book features active young researchers from around the world, who are currently educating the brain scientists of tomorrow.




Methods and Models in Neurophysics


Book Description

1. E. Marder, Experimenting with theory -- 2. A. Borysuk and J. Rinzel, Understanding neuronal dynamics by geometrical dissection of minimal models -- 3. D. Terman, Geometry singular perturbation analysis of neuronal dynamics -- 4. G. Mato, Theory of neural synchrony -- 5. M. Shelley, Some useful numerical techniques for simulating integrate-and-fire networks -- 6. D. Golomb, Propagation of pulses in cortical networks: the single-spike approximation -- 7. M. Tsodyks, Activity-dependent transmission in neocortical synapses -- 8. H. Sompolinsky and J. White, Theory of large recurrent networks: from spikes to behavior -- 9. C. van Vreeswijk, Irregular activity in large networks of neurons -- 10. N. Brunel, Network models of memory -- 11. P. Bressloff, Pattern formation in visual cortex -- 12. F. Wolf, Symmetry breaking and pattern selection in visual cortical development -- 13. A. Treves and Y. Roudi, On the evolution of the brain -- 14. E. Brown, Theory of point processes for neural syst ...




Neuroscience in the 21st Century


Book Description

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.




The Circuitry of the Human Spinal Cord


Book Description

Studies of human movement have proliferated in recent years, and there have been many studies of spinal pathways in humans, their role in movement, and their dysfunction in neurological disorders. This comprehensive reference surveys the literature related to the control of spinal cord circuits in human subjects, showing how they can be studied, their role in normal movement, and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks, and changes in patients with CNS lesions. Each chapter concludes with a helpful resume that can be used independently of the main text to provide practical guidance for clinical studies. This will be essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.




Neuronal Dynamics


Book Description

This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.




Handbook of Brain Microcircuits


Book Description

In order to focus on principles, each chapter in this work is brief, organized around 1-3 wiring diagrams of the key circuits, with several pages of text that distil the functional significance of each microcircuit




Jasper's Basic Mechanisms of the Epilepsies


Book Description

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.




Personality Dimensions and Arousal


Book Description