Molecular Biology of the Cell
Author :
Publisher :
Page : 0 pages
File Size : 42,9 MB
Release : 2002
Category : Cells
ISBN : 9780815332183
The Heterogeneity of Cancer Metabolism
Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 29,51 MB
Release : 2018-06-26
Category : Medical
ISBN : 331977736X
Book Description
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Human Stem Cell Manual
Author : Suzanne Peterson
Publisher : Academic Press
Page : 652 pages
File Size : 35,76 MB
Release : 2012-10-22
Category : Science
ISBN : 0123854741
Book Description
This manual is a comprehensive compilation of "methods that work" for deriving, characterizing, and differentiating hPSCs, written by the researchers who developed and tested the methods and use them every day in their laboratories. The manual is much more than a collection of recipes; it is intended to spark the interest of scientists in areas of stem cell biology that they may not have considered to be important to their work. The second edition of the Human Stem Cell Manual is an extraordinary laboratory guide for both experienced stem cell researchers and those just beginning to use stem cells in their work. - Offers a comprehensive guide for medical and biology researchers who want to use stem cells for basic research, disease modeling, drug development, and cell therapy applications - Provides a cohesive global view of the current state of stem cell research, with chapters written by pioneering stem cell researchers in Asia, Europe, and North America - Includes new chapters devoted to recently developed methods, such as iPSC technology, written by the scientists who made these breakthroughs
Fibroblasts
Author :
Publisher : BoD – Books on Demand
Page : 131 pages
File Size : 24,36 MB
Release : 2021-12-22
Category : Technology & Engineering
ISBN : 1789857996
Book Description
Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer presents recent advances in understanding the roles of fibroblasts and mesenchymal stem cells in tissue homeostasis and the development of human disease. The book delves into general principles of fibroblast and mesenchymal stem cell biology and their diversity across the human body. It highlights these cells’ unique and shared characteristics across organs (e.g., vasculature, kidney, joints and exocrine glands) and specific pathologies (e.g., tissue damage, inflammation, fibrosis and cancer). A particular focus is set on the roles of fibroblasts in disease chronicity, recurrence, progression, therapeutic resistance and utilisation of the advancing knowledge for developing new therapeutic approaches within and beyond disease boundaries.
Mechanisms of Vascular Disease
Author : Robert Fitridge
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 12,11 MB
Release : 2011
Category : Medical
ISBN : 1922064009
Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Skin Tissue Engineering
Author : Sophie Böttcher-Haberzeth
Publisher : Springer Nature
Page : 260 pages
File Size : 43,14 MB
Release : 2019-05-30
Category : Science
ISBN : 1493994735
Book Description
This volume provides protocols describing the isolation and culture of diverse cell types stemming from the skin and the use of these cells and cell constructs for wound healing, bioengineering applications, and translational medicine purposes. The book is divided into three sections describing the isolation and culture of diverse skin cells, managing these cells within co-culture systems and skin models, as well as using these skin models in a test setting. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Skin Tissue Engineering: Methods and Protocols serves as a vital aid to basic and clinical researchers such as biologists, physicians, and biomedical engineers working with and being interested in basic science, and clinically and laboratory-applicable translational regenerative medicine.
Innovative Medicine
Author : Kazuwa Nakao
Publisher : Springer
Page : 330 pages
File Size : 20,25 MB
Release : 2015-10-13
Category : Science
ISBN : 4431556516
Book Description
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Tumor-Associated Fibroblasts and their Matrix
Author : Margareta M. Mueller
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 16,64 MB
Release : 2011-07-28
Category : Medical
ISBN : 9400706596
Book Description
During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on “Tumor-associated fibroblasts and their matrix” as part of the series on “Tumor-Microenvironment” is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy.
Tissue Repair, Contraction and the Myofibroblast
Author : Christine Chaponnier
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 37,6 MB
Release : 2007-02-26
Category : Science
ISBN : 0387336508
Book Description
Tissue Repair, Contraction and the Myofibroblast summarizes the latest findings concerning the biology of the myofibroblast, a cell involved in the evolution and contraction of granulation tissue and of fibrotic changes. Coverage shows that the myofibroblast is responsible for the development of hypertrophic scars, pulmonary and renal fibrosis and bronchial asthma. Reviews the cell biology and pathology of the myofibroblast as well as mechanisms of fibrosis evolution in many organs and tissues.
General Histology of the Mammal
Author : Radivoj V. Krstic
Publisher : Springer Science & Business Media
Page : 689 pages
File Size : 38,29 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642704204
Book Description
With a Foreword by Reiter R.J. Translated by Forster, S.
