Author : Richard Bucala
Publisher : World Scientific
Page : 335 pages
File Size : 23,73 MB
Release : 2012
Category : Medical
ISBN : 9814343722
This volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad audience of scientists and clinicians with an interest in the role of circulating fibrocytes in the etiopathogenesis of different fibrosing disorders, atherosclerosis, autoimmunity, and cancer.
Author : Richard Bucala
Publisher : World Scientific
Page : 268 pages
File Size : 42,40 MB
Release : 2007
Category : Science
ISBN : 9812568697
Since the discovery of the circulating ?fibrocyte? in 1994 as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell populaton has grown steadily. This pioneering new book provides the first comprehensive review of the role of fibrocytes in wound repair, granuloma formation, antigen presentation, scar formation, and various fibrosing disorders such as interstitial lung disease and nephrogenic systemic fibrosis. It also includes discussions of the recent studies on the molecular signals that influence fibrocyte migration, proliferation, and function in the context of normal physiology and pathology. The chapters are contributed by the leading researchers in the field.
Author : Eli D. Ehrenpreis
Publisher : Springer Nature
Page : 516 pages
File Size : 45,8 MB
Release : 2021-09-02
Category : Medical
ISBN : 3030719634
Recent discoveries and clarifications of known information about the mesentery have now established that these complex structures function together as an individual organ within the human body. As such, conditions that affect the mesentery can now be grouped within a single area of study and clinical practice. The various aspects of mesenteric diseases have not been brought together in a single source and this book aims to bring them together for the first time. It will cover general areas such as anatomy, histology and physiology of the mesentery. A description of diagnostic procedures used to evaluate patients with mesenteric disorders will follow. A practical survey with detailed descriptions of medical, surgical, and neoplastic disorders of the mesentery is also be included. This book is intended to be a guide for clinical practitioners including gastroenterologists, general surgeons, colorectal surgeons, primary care physicians, nurse practitioners and physician assistants who manage patients with mesenteric disorders.
Author :
Publisher :
Page : 0 pages
File Size : 49,90 MB
Release : 1994
Category :
ISBN :
Author : Sir James Paget
Publisher :
Page : 524 pages
File Size : 28,12 MB
Release : 1853
Category : Pathology, Surgical
ISBN :
Author : Albert C. Shaw
Publisher : Humana
Page : 0 pages
File Size : 43,61 MB
Release : 2015-09-30
Category : Medical
ISBN : 9781493929627
In this volume, expert researchers detail protocols for evaluating the protean effects of immunosenescence on innate and adaptive immune function, including approaches to the analysis of antigen receptor repertoire. In addition, Immunosenecence: Methods and Protocols guides readers through cell biology and biochemical methods for analyses of telomere dysfunction, autophagy, protein oxidation, microRNAs and DNA methylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunosenecence: Methods and Protocols provides a mixture of basic and advanced protocols that will be useful for immunologists in general and investigators in aging biology in particular.
Author : Richard Bucala
Publisher : World Scientific
Page : 399 pages
File Size : 28,1 MB
Release : 2012
Category : Medical
ISBN : 9814335355
The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Author : Venkataramana K Sidhaye
Publisher : Academic Press
Page : 277 pages
File Size : 10,30 MB
Release : 2017-03-09
Category : Medical
ISBN : 0128038810
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. - Provides a single source of information on lung epithelial junctions and transporters - Discusses of the role of the epithelium in lung homeostasis and disease - Includes capsule summaries of main conclusions as well as highlights of future directions in the field - Covers the mechanistic basis for lung disease for a range of audiences
Author :
Publisher : ScholarlyEditions
Page : 659 pages
File Size : 50,68 MB
Release : 2012-01-09
Category : Medical
ISBN : 1464965978
Issues in Hematology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hematology. The editors have built Issues in Hematology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hematology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Hematology / 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Deborah Elstein
Publisher : Springer Science & Business Media
Page : 525 pages
File Size : 28,84 MB
Release : 2010-08-02
Category : Medical
ISBN : 9048190339
Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.
