Focus on Glaucoma Research


Book Description

Glaucoma is a group of disorders characterised by an abnormally high intraocular pressure (IOP), which can damage the optic nerve and lead to blindness. Glaucoma occurs in several forms: chronic open-angle (primary), acute angle-closure, congenital (inherited as an autosomal recessive trait), and secondary to other causes. Chronic open-ended glaucoma constitutes about 90% of the instances of glaucoma and is frequently familial in nature. Congenital glaucoma can be triggered by varicella, mumps, parvovirus, HIV and herpes among others. Secondary glaucoma can result from trauma and drugs such as steroids. This new book includes within its scope the prevention, pathogenesis, etiology, diagnosis and treatment of glaucoma. International research efforts are reported.




The Science of Glaucoma Management


Book Description

The Science of Glaucoma Management: From Translational Research to Next-Generation Clinical Practice bridges the gap between laboratory research and clinicians by bringing the latest promising research directly from researchers to clinicians long before they translate into clinical advances, and often before they are presented at conferences. Organized as a series of clinically relevant topics written by world-leading experts, this book summarizes the current state of laboratory and translational research and draws on the potential implications for day-to-day clinical practice. It offers new insights and mind-opening statements through contributions from some of the most respected glaucoma research groups. The book allows glaucoma specialists to explore novel ways to refine and rethink their practice based on the latest discoveries in basic sciences and breakthrough technologies, and to gain a better understanding on how their specialty is evolving and how research may shape tomorrow’s practice. Presents a detailed report on the latest translational research and breakthroughs that may transform glaucoma practice Overviews the specialty from a scientific and clinical point-of-view Written by world-renowned clinicians and researchers in the field of glaucoma Includes insights, opinions and recommendations from some of the most prominent scientists and ophthalmologists Covers hot topics and the latest technologies in glaucoma, such as minimally invasive glaucoma surgery, telemedicine, gene therapy, neuroprotection and artificial intelligence




Glaucoma Research and Clinical Advances


Book Description

Foreword Volume 2 of our serial publication continues our desire to address glaucoma with a combination of science and speculation. As science expands, the emphasis is on data, interpretation, and dogma. We disagree; open minds open new approaches. Using methodologies that are primarily molecular and genetic, we seek to refine the causes of glaucoma as well as how it is best treated, especially incorporating thoughts and hypotheses about new methods of treatment. Glaucoma is a complex disease, and genetics proves that a variety of proteins are culpable at one level. At another level, however, there are likely final common pathways and numerous feedback loops which have defied explanations to date. The search for answers goes on in basic science researcher’s laboratories and clinical ophthalmologist’s offices and operating rooms. We are all well-served by understanding that glaucoma is a neurodegenerative disease. Current attempts to solve the disease have focused on two strategic arenas: the trabecular meshwork function and its impact on intraocular pressure as a major risk factor for the disease; and the optic nerve dysfunction leading to visual loss. Genetic mutations have yielded puzzling clues to the cause, but without resolution. For example, mutations in myocilin and optineurin genes are closely connected to the phenotype, but how do they cause the disease? In the next two years, priority areas of research are signaling pathway discoveries, biomarker panels, epigenetic factors, and continued genomic studies to yield answers to the common final pathways of the disease. The final pathways are complex and redundant, such that the overlap of bio-informatics will be challenging. Current promising leads suggest the innate immune system holds important clues to both trabecular meshwork and optic nerve pathophysiology. When the primary open-angle glaucoma disease pathways are unraveled, drug discoveries and new treatment modalities will be available for better regulation of intraocular pressure and neuroprotection for the optic nerve. This volume discusses the glaucoma pipeline from several perspectives as well as future candidate classes. As always, the authors herein are urged to speculate on how the cure of glaucomatous optic nerve damage will yield to new treatments. John R. Samples Clinical Professor, Elson S. Floyd College of Medicine, Washington State University School of Medicine www.glaucomaconcepts.com Paul A. Knepper Associate Professor of Ophthalmology, Feinberg School of Medicine, Northwestern University Medical School Research Scientist, University of Illinois at Chicago







Webvision


Book Description




Glaucoma


Book Description

Glaucoma is infamous as ΄the sneak thief of sight΄: the most common types give no warning they are slowly, progressively destroying a person΄s vision. Because usually the vision at first is affected to the side, patients notice little, if anything. By the time an individual realizes something is wrong, there may have been considerable damage. Why write a book about it? And why dedicate it to all patients with glaucoma, to their relatives and friends, to the general community as well as to ophthalmologists, other doctors and eye health care practitioners who wish to be familiar with management of this group of diseases? Undisturbed, glaucoma blinds people. It respects neither gender nor education; it ignores wealth and privilege. We have no cure for it and we cannot reverse the damage that it has caused. Glaucoma affects about 2% of people over 40 years of age. It is not rare. It is the commonest cause of irreversible and preventable visual disability everywhere. But most of the time we can control it. Successful protection of vision depends in part on how much damage has been done when first detected and how aggressive the disease is for an individual patient. So the earlier glaucoma is diagnosed, the less damage that has been caused, the better the long-term outlook. Early detection requires informed communities whose members seek eye examinations as well as knowledgeable and appropriately equipped eye health care professionals who recognize subtle warning signs and arrange timely ophthalmological confirmation and initiation of effective treatment. This requires access to a worthwhile health system. Even in developed societies, about 50% of patients with glaucoma have not been diagnosed and are not on treatment. Half of these undiagnosed people have been seen by an eye health care practitioner in the last two years. We wish to enlighten our readers with quality information to minimise visual disability from glaucoma.




Advances in Glaucoma Research and Treatment: 2011 Edition


Book Description

Advances in Glaucoma Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Glaucoma in a concise format. The editors have built Advances in Glaucoma Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Glaucoma in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Glaucoma Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.




Glaucoma


Book Description

This second edition volume expands on the previous edition with an update on the latest methodologies used to study the neurodegeneration of glaucoma. This book notably features a focus on ocular hypertension as an important factor in the pathogenesis of glaucoma, and the relationship between elevated intraocular pressure and neurodegeneration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Glaucoma: Methods and Protocols, Second Edition is a valuable resource for anyone interested in glaucoma research. This book will encourage innovation and facilitate progress toward improving our understanding and treatment of glaucoma.




Fighting Glaucoma


Book Description

The long term challenges faced by people with glaucoma are numerous and important. With such a diagnosis, you have to balance many life demands, of which eye treatments are essential but by no means alone. After all, you are not living to treat glaucoma: you are living a full life into which the treatment of your condition is an intrusion. Several books written for patients describe what glaucoma is, how it is being treated, and the state of glaucoma research. We are unaware of a book on how to live with the glaucomas, covering practical challenges frequently faced by those with glaucoma, who wish to minimize risk of visual disability or even blindness. This handbook has been written by an unlikely combination of a physician and a patient. Ivan Goldberg is a world recognized expert in glaucoma treatment. Nahum Goldmann is an experienced high-tech executive, university professor and information scientist. What united us in writing this book is a desire to help people with glaucoma in a practical way. Treatment of any chronic and serious medical condition is likely to be affected by many other factors, such as money, the wellbeing of your family, your general health, other calls on your time, fitness and lifestyle, housing, your work commitments, and perhaps supporting family members, to name just a few. You could use this handbook as an everyday reference or as a guide to your glaucoma treatment. We hope you will find it worthwhile to formulate better the reasons for your actions and for your sometimes complicated choices. We try to address specific issues and anxieties that people with glaucoma might face daily, whether large or small. We aim to guide newly diagnosed individuals, their family and friends, on 'what is best to do' – and 'why'. This handbook's focus is on the step by step actions that you, as well as supporting relatives and friends, can take to improve your current situation and outlook. We try to guide you where to find additional help to understand better your condition and your prospects. We hope health professionals who help people with glaucoma also find this book useful. A digital version of this handbook could be read using computerized gadgets for visually impaired. It could also be computer-translated on the fly to various other languages and without cost, thus reaching the worldwide majority of glaucoma patients who do not read English. To those who would like to learn more about background science and numerous illustrations, we recommend a companion book by one of our co authors, Glaucoma: How to save your sight!, by I. Goldberg and R. Susanna Jr. (Kugler Publications, 2015).




Clinical Glaucoma Care


Book Description

Glaucoma Clinical Care: The Essentials is a pragmatic, slimmer companion volume to the more academically focused text “The Glaucoma Book” by the same editors. This new book is a thoroughly updated manual for the day-to-day diagnosis and management of glaucoma patients by comprehensive ophthalmologists and optometric physicians. Its 33 chapters are authored by world renowned experts in clinical care and basic research, providing evidenced-based research, office examination skills, clinical pearls, and up-to-date reviews of the scientific literature on glaucoma, as wel l as extensive graphics and tables to accompany the text. Glaucoma Clinical Care: The Essentials is the one book to have and consult when confronted with a problematic glaucoma patient sitting in your exam chair as it is a thorough presentation of glaucoma medications, laser, and incisional glaucoma surgeries, complete with commentaries on advantages and disadvantages of the different therapies.