Foot Surgery Viewed Through the Prism of Comparative Anatomy


Book Description

Comparative anatomy helps to define among surgical procedures, those that are able to restore early walking function using really useful structures, without necessarily respecting the normal anatomy. This book proposes an original vision based on the following ideas : The cure is complete only if it occurs quickly, which is vital for vulnerable patients. The surgical goal isnt the anatomical restitution ad integrum, but to resore the fonction, that of the permanent terrestrial human bipedalism. To identify it, put it back into its evolutionary context and compare it to the anatomo-functional models of our closest relatives, the great apes. Achieving this dual objective through new surgical techniques (percutaneous and minimally invaseve), associated with biomechanical data for immediate and total support.




Looking at Ribozymes


Book Description

Behind the neologism “ribozymes” lies a family of fascinating molecules, ribo-enzymes, which have been relatively little studied. These catalytically active RNAs are found in all strata of life, from viruses to the human genome. At the end of the 1970s, the discovery of a catalytic RNA nestled in an intron, followed by another involved in the maturation of transfer RNAs, led to the discovery of new ribozymes and the transition from a strictly “proteocentric” vision, inherited from the dogma of molecular biology, to a more “nucleocentric” one. Since then, a variety of ribozymes have been identified in genomes, where their functions often remain mysterious. Looking at Ribozymes traces the discovery of these molecules and presents a picture of their functional diversity, catalytic mechanisms and distribution within the tree of life.




Biobanks in Healthcare


Book Description

Biobanks ensuring the governance and management of biological resources have become essential entities. The development of biotechnologies, the increased prevalence of biological drugs and the identification of biomarkers associated with molecular classifications of tissue lesions make it essential to have organized access to human biological samples, which have become precious and rare. The digital era and the production of massive data that comes with it have rendered biobanks the guarantors of the reproducibility of experiments and of the overall quality of medical research. Biobanks in Healthcare explores the upheaval linked to the massive deployment of digital health and precision medicine. The future of health biology lies in the deployment of biobanks in fields that have yet to be explored, putting them at the forefront of this extraordinary 21st-century research adventure.




Phyllotaxis and Symmetry in Angiosperms


Book Description

Symmetry and the causes of shifts in different types of symmetries in flowers follow specific patterns that are ruled by developmental and genetic factors. Using a unified system of phyllotaxic equations, we have modeled the molecular mechanisms and pressure forces that act in inflorescence and floral meristems, giving flowers their organ arrangement. In this book, we state general physical principles, whereby the symmetry of the perianth is derived from the symmetry of certain TCP gene expression. Thus, we define the interplay between the expression of CYC2-like genes and the phyllotactic mechanisms. This new evo-devo approach is applied to major groups of angiosperms with predominantly actinomorphic flowers (in which rare zygomorphy is positional) and groups with mainly bilaterally symmetrical flowers (in which zygomorphy is constitutional). It has thus allowed us to revisit the contributions of the great floral morphologists of the 20th and early 21st centuries.




Concepts in Biology


Book Description

This book provides a comprehensive review of the history of concepts of the endocrine, nervous and immune systems throughout the last century. Historically, these systems were long considered as compartments that performed separate and different functions. However, a breakthrough occurred when advances in genetics and cellular and molecular biology techniques revealed that these systems shared molecular entities (such as cytokines, hormones and neurotransmitters) with their cognate receptors. These molecular links between the three systems broaden our understanding of the regulation of physiological processes. This approach has generated a multiplicity of new concepts, including crosstalk between organs, axis, feedback, molecular sensors, protein multi-functionality, positive and negative signaling ratios and pathways (such as cell signaling, metabolism and stem cell differentiation, to name a few). The improvement of experimental approaches has often resulted in major discoveries. This, combined with clear reasoning, intuition and coherence gave rise to new and unexpected concepts, and sometimes evolving ones. These new concepts lead the reader to the incredible transformation of biology in recent years.




Asymptomatic Osseous Variations of the Postcranial Human Skeleton


Book Description

Since ancient times, asymptomatic bone variations have been studied in many different disciplines. In radiology, for example, they enable the differentiation of the typical from the anomalous, but in biological anthropology they are especially useful in answering questions about humans and their diachronic and synchronic variability. This book provides an easily accessible presentation of the osseous variations of the postcranial skeleton (from the spine to the feet), which are sometimes poorly understood by the scientific community. These variations are examined one by one, with definitions, population frequencies and complete illustrations given for each. Asymptomatic Osseous Variations of the Postcranial Human Skeleton is intended as a comprehensive reference manual for further research on these types of skeletal variations.




Inventory of Biodiversity Today


Book Description




Embryogeny and Phylogeny of the Human Posture 2


Book Description

The future of the human posture is in the spotlight. The 200-year-old locomotion paradigm can no longer resist the advancement of knowledge, yet 2,500 years of thinking on the place of verticalized human anatomy and its reflexive consciousness in the natural history of life and the Earth, is more relevant than ever. This book retraces these reflections from pre-Socratic philosophers, focusing on the link between verticality and the most complex and consciously reflexive nervous system on the top rung of the ladder of living beings. The origin of animated forms, or animals, was considered metaphysical until the 19th century but reflection on their inception, from fertilization, paved the way for mathematics of infinitesimal geometry and dynamics. The simian filiation was inconceivable until Jean-Baptiste de Lamarck bridged the gap in 1802 with the locomotion postulate to explain the transition from quadrupedal to bipedal posture, sustained by the hypothesis of inheritance of acquired characteristics. This doctrine was overturned in 1987 by the discovery of the embryonic origins of the straightening – specific dynamics linked to neurogenesis – confirming the natural place of human verticality and nervous system complexity with its psychomotor and cognitive consequences. Sapiens find themselves at the physical limit of the straightening while mechanisms of gametogenesis have never ceased in making neurogenesis exponentially more complex. Is the future exclusively terrestrial or does intrauterine hominization open up new perspectives for space exploration? Posturologists, occlusodontics, osteopaths, cognisciences – all anthropological sciences exposed to human verticality are concerned with this discovery, which allows Sapiens to face their natural destiny.




Fifty Years of Evolution in Biological Research


Book Description

Research in biology and all basic sciences has undergone profound transformations in recent decades. We have seen the development of extremely sophisticated techniques, allowing us to study, in an objective manner, questions that were still considered science fiction at the end of the 20th century. All of this has allowed us to develop an in-depth knowledge of vast subjects, such as the biology of the brain, for example. Fifty Years of Evolution in Biological Research presents a panorama of these different technical advances. However, at the same time, there has been an increase in the number of constraints on researchers, a monetization of research and a correlative pressure to continually publish in more prestigious journals. This has resulted in a certain degradation of the quality of research activity. This book analyzes this evolution and proposes solutions.




Bergman's Comprehensive Encyclopedia of Human Anatomic Variation


Book Description

Building on the strength of the previous two editions, Bergman's Comprehensive Encyclopedia of Human Anatomic Variation is the third installment of the classic human anatomical reference launched by Dr. Ronald Bergman. With both new and updated entries, and now illustrated in full color, the encyclopedia provides an even more comprehensive reference on human variation for anatomists, anthropologists, physicians, surgeons, medical personnel, and all students of anatomy. Developed by a team of editors with extensive records publishing on both human variation and normal human anatomy, Bergman's Comprehensive Encyclopedia of Human Anatomic Variation is the long awaited update to this classic reference.