Free Radicals and Oxidation Phenomena in Biological Systems


Book Description

This work offers an analysis of the biological processes mediated by free radicals, from a toxicological point of view, providing easy access to information in an integrated, coherent presentation. The chemistry and biochemistry of all principal types of radical are explained, and the multiple forms in whch radicals participate in living organisms are investigated.;This work should be of use to biochemists, pharmacologists, pharmaceutical researchers, food scientists and technologists, nutritionists, toxicologists, chemists, biologists and graduate students in these disciplines.




Oxygen Radicals in Biology and Medicine


Book Description

This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.




Flavonoids in Health and Disease, Second Edition,


Book Description

Revised and expanded throughout, this blue-ribbon reference emphasizes the latest developments in the identification, utilization, and analysis of flavonoids for the prevention of disease and maintenance of good health-examining the processes involved in the absorption, metabolism, distribution, and excretion of these compounds and the impact of biotransformation on flavonoid function.




Nutraceuticals in Health and Disease Prevention


Book Description

Promoting scientific support for the plethora of health benefits related to nutrition and medicine, Nutraceuticals in Health and Disease Prevention delivers a comprehensive and scientifically sound overview of the latest research findings in disease prevention, therapy, and enhanced body function in the revolutionary field of nutraceutical technology-with highlights from the Nutraceutical Conference held in Ludwigshafen, Germany. Includes perspectives and reviews from recognized experts on nutraceuticals of scientific and public interest! Recognizing the need to control the balance between environmental stressors and human health, Nutraceuticals in Health and Disease Prevention presents developing areas of nutraceutical research with studies of effective examples examines pathology treatments, including effects of S-adenosylmethionine (SAMe) on inflammatory disease and polyphenols on cardiovascular disease investigates the role and benefits of vitamin E in aging and the antioxidant network discusses the potency, multiple uses, and metabolic aspects of lipoic (thioctic) acid reviews the second generation of carotenoid research and the disease prevention properties of lycopene and lutein considers how polyunsaturated fatty acids (PUFAs) contribute to a healthy diet, from clinical and molecular perspectives profiles the efficacy, safety, and use of creatine as an anabolic nutraceutical by athletes analyzes identification methods for optimum delivery of nutrients, illustrated by the example of methyltetrahydrofolate and much more! Containing over 1100 valuable literature references, drawings, and tables, Nutraceuticals in Health and Disease Prevention functions as an indispensable reference in the libraries of nutritionists and dietitians, pharmacists, molecular and cell biologists and biochemists, oncologists, endocrinologists, dermatologists, physiologists, epidemiologists, neurochemists, pediatricians, and upper-level undergraduate, graduate, and medical school students in these disciplines.




Handbook of Food Science, Technology, and Engineering - 4 Volume Set


Book Description

Advances in food science, technology, and engineering are occurring at such a rapid rate that obtaining current, detailed information is challenging at best. While almost everyone engaged in these disciplines has accumulated a vast variety of data over time, an organized, comprehensive resource containing this data would be invaluable to have. The




Preventive Nutrition


Book Description

Nutrition has been recognized as a major determinant of health for centuries. Tradi tionally, nutritional sciences have primarily targeted the prevention of diseases resulting from clinical deficiencies of essential nutrients, such as scurvy and rickets. Contempo rary nutritional research has focused on the prevention of major diseases of Western civilization, particularly cardiovascular disease and cancer, as well as promoting mater nal and child health and healthy aging. Heart disease and cancer, which were rare in most developing countries several decades ago, are increasing dramatically in these countries, in parallel with economic development and dietary transitions, decreases in infectious diseases, and increasing sedentary lifestyle and obesity. Substantial evidence indicates major chronic diseases such as coronary heart disease, type 2 diabetes, and some cancers are largely preventable by relatively simple diet and lifestyle modifications. Despite the great potential of nutrition in preventing diseases and improving health, nutrition is not routinely emphasized in the education and training of physicians and other health care professionals. This has resulted in inadequate nutritional knowledge and lack of skills in providing dietary counseling among many health care professionals. Further more, in the past decade, the public's access to nutritional information has been increas ing rapidly, particularly through the Internet. There are now hundreds of websites providing a wide range of nutritional information and selling numerous dietary products. Because of the explosion in nutritional information, the public's demand for nutritional advice has been increasing rapidly and will continue to rise.




Handbook of Synthetic Antioxidants


Book Description

Emphasizes the efficacy of synthetically occurring compounds in the management of free radical-mediated illnesses. The text details the design, development and delivery of therapeutic antioxidants used in the treatment of pathophysiological disorders, from amylotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) to Alzheimer's disease.




Thiamine


Book Description

Thiamine: Catalytic Mechanisms in Normal and Disease States brings together the most recent developments in thiamine diphosphate (TDP)-requiring enzyme research and details the mechanisms of catalysis and structure-function relationships, as well as pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing new insights into neurogenerative diseases, this volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states and offers novel aspects of thiamine enzymes in chiral synthesis as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.




Oxidation and Antioxidants in Organic Chemistry and Biology


Book Description

Providing a comprehensive review of reactions of oxidation for different classes of organic compounds and polymers, and biological processes mediated by free radicals, Oxidation and Antioxidants in Organic Chemistry and Biology puts the data and bibliographical information you need into one easy-to-use resource. You will find up-to-date information




Redox-Genome Interactions in Health and Disease


Book Description

At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.