From One Cell: A Journey into Life's Origins and the Future of Medicine


Book Description

“Insightful and erudite.”—Adrian Woolfson, Wall Street Journal Inside the quest to unlock the mysteries of development—and find the key to transforming our future. Each of us began life as a single cell. From this humble origin, we embarked on a risky journey fraught with opportunities for disaster. Yet, amazingly, we reached our destination intact, emerging as dazzlingly complex, exquisitely engineered assemblages of trillions of cells. This metamorphosis constitutes one of nature’s most spectacular yet commonplace magic tricks—and one of its most coveted secrets. In From One Cell, physician and researcher Ben Stanger offers a breathtaking glimpse into what scientists are discovering about how life and the body take shape, and how these revelations stand to revolutionize medicine and the future of human health. In vivid prose, Stanger leads readers on a gripping odyssey retracing this universal, yet unremembered, rite of passage. Through the eyes of the scientists unraveling development’s riddles in experiments as painstaking as they are inventive, we confront fascinating puzzles: how does the plethora of different tissues that compose our bodies arise from a single source? How do cells know what they are meant to become—skin or bone, blood or muscle—when all carry the same set of genetic instructions? Once a cell starts developing down one path, can it change its mind, or is its destiny irrevocably sealed? As Stanger shows us, the answers to these questions may at last empower us to solve some of our most persistently confounding medical challenges, from cancer to cognitive decline to degenerative disease. Recognizing tumors as evil doppelgangers of the embryo points the way toward new, more targeted cancer therapies. Learning how cells choose their identities and find their way in space could unlock lifesaving breakthroughs in regenerative medicine. The possibilities are extraordinary. Popular science at its best, From One Cell celebrates the power and beauty of understanding our collective beginnings.




The Dance of Life


Book Description

'Quite simply the best book about science and life that I have ever read' - Alice Roberts How does life begin? What drives a newly fertilized egg to keep dividing and growing until it becomes 40 trillion cells, a greater number than stars in the galaxy? How do these cells know how to make a human, from lips to heart to toes? How does your body build itself? Magdalena Zernicka-Goetz was pregnant at 42 when a routine genetic test came back with that dreaded word: abnormal. A quarter of sampled cells contained abnormalities and she was warned her baby had an increased risk of being miscarried or born with birth defects. Six months later she gave birth to a healthy baby boy and her research on mice embryos went on to prove that – as she had suspected – the embryo has an amazing and previously unknown ability to correct abnormal cells at an early stage of its development. The Dance of Life will take you inside the incredible world of life just as it begins and reveal the wonder of the earliest and most profound moments in how we become human. Through Magda’s trailblazing research as a professor at Cambridge – where she has doubled the survival time of human embryos in the laboratory, and made the first artificial embryo-like structures from stem cells – you’ll discover how early life is programmed to repair and organise itself, what this means for the future of pregnancy, and how we might one day solve IVF disorders, prevent miscarriages and learn more about the dance of life as it starts to take shape. The Dance of Life is a moving celebration of the balletic beauty of life’s beginnings.




The Secret Language of Cells


Book Description

Your cells are talking about you. Right now, both your inner and outer worlds are abuzz with chatter among living cells of every possible kind—from those in your body and brain to those in the environment around you. From electrical alerts to chemical codes, the greatest secret of modern biology, hiding in plain sight, is that all of life's activity boils down to one thing: conversation. While cells are commonly considered the building block of living things, it is actually the communication between cells that brings us to life, controlling our bodies and brains, determining whether we are healthy or sick, and directly influencing how we think, feel, and behave. In The Secret Language of Cells, doctor and neuroscientist Jon Lieff lets us listen in on these conversations, and reveals their significance for everything from mental health to cancer. He explains the surprising science of how very different cells—bacteria and brain cells, blood cells and viruses—all speak the same language. This overarching principle has been long overlooked because scientific journals use impenetrable jargon that makes it hard to be understood across disciplines, much less by the general public. Lieff presents a fascinating and accessible look into cellular communication science—a groundbreaking and comprehensive exploration of this biological phenomenon. In these pages, discover the intriguing lives of cells as they ask questions, get answers, give feedback, gather information, call for each other, and make complex decisions. During infections, immune T-cells tell brain cells that we should "feel sick" and lie down. Cancer cells warn their community about immune and microbe attacks. Gut cells talk with microbes to determine which are friends and which are enemies, and microbes talk with each other and with much more complicated human cells in ways that determine which medicines work and which will fail. With applications for immunity, chronic pain, weight loss, depression, cancer treatment, and virtually every aspect of health and biology, cellular communication is revolutionizing our understanding not just of disease, but of life itself. The Secret Language of Cells is required reading for anyone interested in following the conversation.




Creation


Book Description

What is life? Humans have been asking this question for thou­sands of years. But as technology has advanced and our understanding of biology has deepened, the answer has evolved. For decades, scientists have been exploring the limits of nature by modifying and manipulating DNA, cells and whole organisms to create new ones that could never have existed on their own. In Creation, science writer Adam Rutherford explains how we are now radically exceeding the boundaries of evolution and engineering entirely novel creatures—from goats that produce spider silk in their milk to bacteria that excrete diesel to genetic circuits that identify and destroy cancer cells. As strange as some of these creations may sound, this new, synthetic biology is helping scientists develop radical solutions to some of the world’s most pressing crises—from food shortages to pandemic disease to climate change—and is paving the way for inventions once relegated to science fiction. Meanwhile, these advances are shedding new light on the biggest mystery of all—how did life begin? We know that every creature on Earth came from a single cell, sparked into existence four billion years ago. And as we come closer and closer to understanding the ancient root that connects all living things, we may finally be able to achieve a second genesis—the creation of new life where none existed before. Creation takes us on a journey four billion years in the making—from the very first cell to the ground-breaking biological inventions that will shape the future of our planet.




The Song of the Cell


Book Description

Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences and the 2023 Chautauqua Prize! Named a New York Times Notable Book and a Best Book of the Year by The Economist, Oprah Daily, BookPage, Book Riot, the New York Public Library, and more! In The Song of the Cell, the extraordinary author of the Pulitzer Prize–winning The Emperor of All Maladies and the #1 New York Times bestseller The Gene “blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner” (Oprah Daily). Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christened them “cells.” The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling, The Song of the Cell tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate—a masterpiece on what it means to be human. “In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes” (The New Yorker).




Freezing Fertility


Book Description

Analyzes how the possibility of egg freezing changes what it means to be fertile and to age in the 21st century Welcomed as liberation and dismissed as exploitation, egg freezing (oocyte cryopreservation) has rapidly become one of the most widely-discussed and influential new reproductive technologies of this century. In Freezing Fertility, Lucy van de Wiel takes us inside the world of fertility preservation—with its egg freezing parties, contested age limits, proactive anticipations and equity investments—and shows how the popularization of egg freezing has profound consequences for the way in which female fertility and reproductive aging are understood, commercialized and politicized. Beyond an individual reproductive choice for people who may want to have children later in life, Freezing Fertility explores how the rise of egg freezing also reveals broader cultural, political and economic negotiations about reproductive politics, gender inequities, age normativities and the financialization of healthcare. Van de Wiel investigates these issues by analyzing a wide range of sources—varying from sparkly online platforms to heart-breaking court cases and intimate autobiographical accounts—that are emblematic of each stage of the egg freezing procedure. By following the egg’s journey, Freezing Fertility examines how contemporary egg freezing practices both reflect broader social, regulatory and economic power asymmetries and repoliticize fertility and aging in ways that affect the public at large. In doing so, the book explores how the possibility of egg freezing shifts our relation to the beginning and end of life.




The Immortal Life of Henrietta Lacks


Book Description

#1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.




A Journey into the Human Experience of Incurable Disease


Book Description

Incurable disease is a natural phenomenon, inherent to the human condition. This book critically investigates the uniquely human experience of and response to illness and treatment, which affects the body, the mind, and the very core of human existence and identity. Uncertainties regarding the outcomes of laboratory and other investigations that aid in the diagnosis and assessment of disease exacerbate the apprehension inherent to the diagnosis of incurable disease. An excessively scientific approach may disregard the suffering patient. The book begins by analysing the nature, meaning and significance of hope in the context of disease, and goes on to reflect on the language of medicine and the role of emotion, ideology and politics in disease treatment and research. The epilogue reflects on healing as distinct from physical cures. Without hope, there is no future; without healing, no holistic recovery. The final chapters are devoted to the end-of-life period of this journey. This book is a revision, extension, and reconceptualization of the original Afrikaans publication Hoop, Heling en Harmonie: Dink Nuut Oor Siekte en Genesing, winner of the 2021 Andrew Murray Prize for Theological Publications.




Your Future Self


Book Description

A visual introduction into the new era of molecular medicine offers striking images that show the effect of therapies upon cancerous cells, stimuli on the brain, and the invasion of HIV




The Story of Germ Life


Book Description

"The Story of Germ Life" by H. W. Conn is a bacteriology book that begins with a discussion of the nature of bacteria. The book shows their position on the scale of plant and animal life. The middle chapters describe the functions of bacteria in the arts, dairy, and agriculture. The final chapters discuss the relation of bacteria to disease and the methods by which the new and growing science of preventive medicine combats and counteracts their dangerous powers.