Disorders of Hemoglobin


Book Description

Completely revised new edition of the definitive reference on disorders of hemoglobin.




Genes, Behavior, and the Social Environment


Book Description

Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.




Case Studies in Immunology


Book Description

This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.




The Genetics of Cancer


Book Description

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.




Assessing Genetic Risks


Book Description

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.




Biochemical and Molecular Basis of Pediatric Disease


Book Description

Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. - Provides a fully-updated resource with more color illustrations - Focuses on the biochemical and molecular basis of disease as well as the analytical techniques - Defines important differences in the pathophysiology of diseases, comparing childhood with adult




Diseases of the Brain, Head and Neck, Spine 2020–2023


Book Description

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.




Genetic and Acquired Disorders


Book Description

Educators often face the pressure to address children's medical needs within the school setting, but sometimes find themselves having to make difficult decisions without adequate training, support, or information about important pediatric issues. When faced with a medical question, many may turn to the Internet where information is sometimes reliable, sometimes not. This concise and well-researched investigation into genetic and acquired health issues provides credibility and verifiability of data and establishes a foundation of confidence for any educator who must make policy, differentiate instruction, provide educational accommodations, offer special education services, collaborate with families, and work with the community to serve to children's medical, physical, and psychological needs. Written for school psychologists, counsellors, administrators, and teachers, this highly practical and easy-to-understand reference describes genetic, chromosomal, and acquired disorders and discusses behavioural issues that may manifest themselves in classrooms as well as treatment options and intervention strategies. Readers will find: - A section on chromosomal, genetic, and metabolic disorders covering topics such as phenylketonuria, the genetics of autism, the biology of shyness, and families of children with genetic disorders - A section on acquired disorders with chapters on prenatal alcohol exposure, prenatal exposure to antidepressants, celiac disease, maternal post-partum depression and behaviour problems, asthma and quality of life, food allergies in the classroom, and diabetes. Each chapter includes a case study, parent handouts, and a literature review based on the latest and best scientific research.




Concepts of Epidemiology


Book Description

First edition published in 2002. Second edition published in 2008.




Rare Diseases and Orphan Products


Book Description

Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.