Epigenetics of Aging


Book Description

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.




Reset Your Body


Book Description

Feel you've done irreparable damage to your body with unhealthy food choices? No matter how much junk food you've eaten, how many exercise routines you've skipped, or how old you are, you can reverse the detrimental effects on your body by 'Reseting.' Yes. You can reset your body's clock and live a healthier, happier life. Think you're too set in your ways to change? You're not. Habits can be changed. By laying out everything in sections, from understanding the harmful chemicals we put in our bodies, to following a series of daily, weekly, monthly and yearly challenges, You'll learn how you can gradually change your lifestyle for the better. This is no quick fix. It's a way of life, but there's no pressure or time constraints. Simply follow this handbook and take things at your own pace.




Grow Younger, Live Longer


Book Description

Human ageing is reversible. Scientific research shows that we can literally turn back the markers of getting old, including blood pressure, muscle strength, cholesterol levels and many others. Using the tools in this book, you can learn specific strategies for melting away those biological years so you can feel, perform and look like you did as many as fifteen years ago. Grow Younger, Live Longer is a complete anti-ageing manual, including a simple programme, at the heart of which are ten essential steps. If you incorporate these into your weekly routine, your age-reversal process will very soon be underway. Combining all the knowledge and pioneering spirit that made Ageless Body, Timeless Mind into a huge international bestseller, with all the latest discoveries in mind/body medicine, Grow Younger, Live Longer will show millions of readers round the world how they can achieve a long life filled with joy and vitality.




Growing Younger


Book Description




The Berlin Aging Study


Book Description

An extensive, multidisciplinary study of old age and aging, ranging from 70 to 100 years.




Counterclockwise


Book Description

Scientifically riveting and practically empowering, "Counterclockwise" offers a bold new way to think about aging and lifelong health from the trailblazing social psychologist and author of the bestselling classic "Mindfulness."




Younger You


Book Description

Based on the groundbreaking study that shaved three years off a subjects' age in just eight weeks, discover a proven, accessible plan to prevent diseases and reduce your biological age. It’s true: getting older is inevitable and your chronological age can only move in one direction. But you also have a biological age, which scientists can measure by assessing how your genes are expressed through epigenetics. Exciting new research shows that your bio age can actually move in reverse—and Dr. Kara Fitzgerald’s groundbreaking, rigorous clinical trial proved it’s possible. By eating delicious foods and establishing common-sense lifestyle practices that positively influence genetic expression, study participants reduced their bio age by just over three years in only eight weeks! Now Dr. Fitzgerald shares the diet and lifestyle plan that shows you how to influence your epigenetics for a younger you. In Younger You you’ll learn: It’s not your genetics that determines your age and level of health, it’s your epigenetics How DNA methylation powerfully influences your epigenetic expression The foods and lifestyle choices that most affect DNA methylation Simple swaps to your daily routines that will add years to your life The full eating and lifestyle program, with recipes and meal plans, to reduce your bio age and increase vitality How to take care of your epigenetic expression at every life stage, from infancy through midlife and your later decades We don’t have to accept a descent into disease and unwellness as we age as inevitable: when you reduce bio age you reduce your odds of developing all the major diseases, including diabetes, cancer, and dementia. With assessment tools for determining your bio age, recipes, and plans for putting it all into practice,Younger You helps you repair years of damage, ward off chronic disease, and optimize your health—for years to come.




Lifespan


Book Description

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.




The Care and Keeping of You Journal


Book Description

This companion to our bestselling book, The Care & Keeping of You, received its own all-new makeover! This updated interactive journal allows girls to record their moods, track their periods, and keep in touch with their overall health and well-being. Tips, quizzes, and checklists help girls understand and express what�s happening to their bodies--and their feelings about it.