Hamster Immune Responses in Infectious and Oncologic Diseases


Book Description

This volume comprises the written contributions of participants in a symposium held in Dallas, Texas, June 3-5, 1980, entitled "HAMSTER IMMUNE RESPONSIVENESS AND EXPERIMENTAL MODELS OF INFECTIOUS AND ONCO LOGIC DISEASES". This meeting followed its predecessor, "Hamster Immune Responses: Experimental Models Linking Immunogenetics, Oncogene sis and Viral Immunity" by three years. This more recent meeting was more pointed in its focus and the contributions appeared to be more tightly associated. These meetings are part of an extend~d effort by experimentalists using the Syrian hamster as an animal model system to bring together workers in potentially related areas for the exchange of ideas and information. The success of the symposia derives partly from the scientific excellence of the contributing scientists, and partly from the financial support of the National Institutes of Health through the Fogarty International Center. The administration of the University of Texas Health Science Center at Dallas, under President Charles C. Sprague, also donated time, facilities, and financial sup port. Preparation of the manuscripts in this volume, as camera-ready copy for the publisher, was the diligent and dedicated effort of Ms. Sara Howard. Copy editing was expertly performed by Ms. Sandra Schulte and proof-reading was the responsibility of Dr. Patricia Fultz and Ms. Alix Gerboth. However, final responsibility for any errors and omis sions in the published volume is taken by the five local editors: J. Wayne Streilein David A. Hart Joan Stein-Streilein William R. Duncan R. E.







Laboratory Animal Medicine


Book Description

A volume in the American College of Laboratory Animal Medicine series, this second edition has over 40% new material, including the addition of six new topics and many others that are completely rewritten. The book comprehensively covers the biological and disease aspects of laboratory animal medicine while examining other aspects such as the biohazards associated with the use of animal experimentation and factors complicating the bioethics of animal research.




Clinical Veterinary Advisor: Birds and Exotic Pets


Book Description

Providing accurate, at-a-glance information on managing the diseases of birds and exotic pets, Clinical Veterinary Advisor: Birds and Exotic Pets is the only comprehensive resource on the market covering birds, reptiles, small mammals, and other non-traditional pets. Concise summaries of hundreds of common medical problems help you consider differential diagnoses, recommend diagnostic tests, interpret results mindful of unique species differences, utilize important concepts of species-specific husbandry and nutrition, prescribe treatments, and provide follow-up care. With contributions from recognized avian and exotics experts and edited by Jörg Mayer and Thomas M. Donnelly, this clinical reference provides all the information you need in one book! Six-books-in-one format includes six separate sections: Diseases and Disorders, Procedures and Techniques, Differential Diagnosis, Laboratory Tests, Clinical Algorithms, and Zoonoses. In-depth, cutting-edge coverage includes all exotic species - birds, reptiles, pocket pets, amphibians, and fish - in one comprehensive resource. Concise summaries feature a definition of each problem, epidemiology, physical findings and clinical presentation, etiology, differential diagnosis, diagnostic workup (such as laboratory tests and imaging studies), treatment, prognosis and patient follow-up, zoonotic potential, and references. Diagnostic and treatment algorithms provide easy-to-follow, step-by-step guidance to clinical assessment and treatment planning. A companion website includes the complete text from the book, making the entire contents fully searchable, along with 250 full-color illustrations, client handouts, and the ability to print out any pages.










Viral Pathogenesis


Book Description

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. - Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis - Provides a fresh perspective on the approaches used to understand how viruses cause disease - Features molecular profiling techniques, whole genome sequencing, and innovative computational methods - Highlights the use of contemporary approaches and the insights they provide to the field




Adverse Effects of Vaccines


Book Description

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.




Heart Failure: A Companion to Braunwald's Heart Disease E-Book


Book Description

Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).




Oncothermia: Principles and Practices


Book Description

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.