Author : Samuel H. Yalkowsky
Publisher : CRC Press
Page : 1513 pages
File Size : 33,25 MB
Release : 2003-03-26
Category : Medical
ISBN : 0203490398
Over the years researchers have reported solubility data in the chemical, pharmaceutical, engineering, and environmental literature for several thousand organic compounds. Until now, this information has been scattered throughout the literature. Containing over 16,000 solubility data points for more than 4,000 organic compounds, Handbook of Aqueous
Author : Abolghasem Jouyban
Publisher : CRC Press
Page : 554 pages
File Size : 24,4 MB
Release : 2009-08-26
Category : Medical
ISBN : 1439804885
Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab
Author : Samuel H. Yalkowsky
Publisher : CRC Press
Page : 1622 pages
File Size : 33,33 MB
Release : 2016-04-19
Category : Medical
ISBN : 1439802467
Over the years, researchers have reported solubility data in the chemical, pharmaceutical, engineering, and environmental literature for several thousand organic compounds. Until the first publication of the Handbook of Aqueous Solubility Data, this information had been scattered throughout numerous sources. Now newly revised, the second edition of
Author : Charles M. Hansen
Publisher : CRC Press
Page : 546 pages
File Size : 47,46 MB
Release : 2007-06-15
Category : Science
ISBN : 1420006835
Hansen solubility parameters (HSPs) are used to predict molecular affinities, solubility, and solubility-related phenomena. Revised and updated throughout, Hansen Solubility Parameters: A User's Handbook, Second Edition features the three Hansen solubility parameters for over 1200 chemicals and correlations for over 400 materials including p
Author : Allan F.M. Barton
Publisher : CRC Press
Page : 774 pages
File Size : 48,19 MB
Release : 1991-10-29
Category : Science
ISBN : 9780849301766
The CRC Handbook of Solubility Parameters and Other Cohesion Parameters, Second Edition, which includes 17 new sections and 40 new data tables, incorporates information from a vast amount of material published over the last ten years. The volume is based on a bibliography of 2,900 reports, including 1,200 new citations. The detailed, careful construction of the handbook develops the concept of solubility parameters from empirical, thermodynamic, and molecular points of view and demonstrates their application to liquid, gas, solid, and polymer systems.
Author : Cynthia G. Zoski
Publisher : Elsevier
Page : 935 pages
File Size : 28,69 MB
Release : 2007-02-07
Category : Science
ISBN : 0444519580
Electrochemistry plays a key role in a broad range of research and applied areas including the exploration of new inorganic and organic compounds, biochemical and biological systems, corrosion, energy applications involving fuel cells and solar cells, and nanoscale investigations. The Handbook of Electrochemistry serves as a source of electrochemical information, providing details of experimental considerations, representative calculations, and illustrations of the possibilities available in electrochemical experimentation. The book is divided into five parts: Fundamentals, Laboratory Practical, Techniques, Applications, and Data. The first section covers the fundamentals of electrochemistry which are essential for everyone working in the field, presenting an overview of electrochemical conventions, terminology, fundamental equations, and electrochemical cells, experiments, literature, textbooks, and specialized books. Part 2 focuses on the different laboratory aspects of electrochemistry which is followed by a review of the various electrochemical techniques ranging from classical experiments to scanning electrochemical microscopy, electrogenerated chemiluminesence and spectroelectrochemistry. Applications of electrochemistry include electrode kinetic determinations, unique aspects of metal deposition, and electrochemistry in small places and at novel interfaces and these are detailed in Part 4. The remaining three chapters provide useful electrochemical data and information involving electrode potentials, diffusion coefficients, and methods used in measuring liquid junction potentials. * serves as a source of electrochemical information * includes useful electrochemical data and information involving electrode potentials, diffusion coefficients, and methods used in measuring liquid junction potentials * reviews electrochemical techniques (incl. scanning electrochemical microscopy, electrogenerated chemiluminesence and spectroelectrochemistry)
Author : Joseph F. Zemaitis, Jr.
Publisher : John Wiley & Sons
Page : 876 pages
File Size : 44,99 MB
Release : 2010-09-16
Category : Technology & Engineering
ISBN : 0470938404
Expertise in electrolyte systems has become increasingly important in traditional CPI operations, as well as in oil/gas exploration and production. This book is the source for predicting electrolyte systems behavior, an indispensable "do-it-yourself" guide, with a blueprint for formulating predictive mathematical electrolyte models, recommended tabular values to use in these models, and annotated bibliographies. The final chapter is a general recipe for formulating complete predictive models for electrolytes, along with a series of worked illustrative examples. It can serve as a useful research and application tool for the practicing process engineer, and as a textbook for the chemical engineering student.
Author : Donald Mackay
Publisher : CRC Press
Page : 1000 pages
File Size : 14,38 MB
Release : 2006-03-14
Category : Science
ISBN : 9781566706872
Transport and transformation processes are key for determining how humans and other organisms are exposed to chemicals. These processes are largely controlled by the chemicals’ physical-chemical properties. This new edition of the Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals is a comprehensive series in four volumes that serves as a reference source for environmentally relevant physical-chemical property data of numerous groups of chemical substances. The handbook contains physical-chemical property data from peer-reviewed journals and other valuable sources on over 1200 chemicals of environmental concern. The handbook contains new data on the temperature dependence of selected physical-chemical properties, which allows scientists and engineers to perform better chemical assessments for climatic conditions outside the 20–25-degree range for which property values are generally reported. This second edition of the Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals is an essential reference for university libraries, regulatory agencies, consultants, and industry professionals, particularly those concerned with chemical synthesis, emissions, fate, persistence, long-range transport, bioaccumulation, exposure, and biological effects of chemicals in the environment. This resource is also available on CD-ROM
Author : Vaseashta, Ashok
Publisher : IGI Global
Page : 728 pages
File Size : 39,74 MB
Release : 2022-03-11
Category : Science
ISBN : 1799873579
Water supports three basic pillars of our life and survival: safety, security, and sustainability. Hence, it is extremely important to revisit the fundamental characteristics of water in order to discover additional information and the characteristics water has that will help uncover pathways to support the United Nations Sustainable Development Goals (UN SDG) to reduce inequality and make cities and human settlements more inclusive, safe, resilient, and sustainable. Clean water is a critical component to meet such goals. While the fundamental physical and chemical properties of water continue to reveal new aspects, it is critical that we review these properties in the context of several recent applications and by case studies. The Handbook of Research on Water Sciences and Society provides the basics of water science, ways to sense/detect and mitigate contaminants, several regional case studies, and societal aspects of water, including the human right to access water. The book serves as a comprehensive knowledge base on the latest fundamental and applied research and scientific innovations regarding the relationships between society and water resources, safe and sustainable use of water, watershed stewardship, industrial application, and public health awareness. Covering a wide range of topics, it is an ideal resource for researchers, professionals, policymakers, scientists, practitioners, instructors, and students.
Author : Alex Avdeef
Publisher : CRC Press
Page : 1730 pages
File Size : 31,94 MB
Release : 2024-05-27
Category : Medical
ISBN : 1003826318
In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism, and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the Wiki-pS0TM database, which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for ‘undruggable’ targets. FEATURES • A comprehensive and unique listing of measured aqueous intrinsic solubility focusing on drug-like and drug-relevant molecules. • The database can be used to predict the solubility of research pharmaceutical molecules. • Includes downloadable files of the database (.csv format). • The mining of the database can result in a better design of solubility assay protocols, leading to better quality of measurements. • Artificial intelligence and Bayesian statistics will likely be key to this subject area in the future. Alex Avdeef has been an American Association of Pharmaceutical Scientists (AAPS) Fellow since 2014, a former visiting senior research fellow at King’s College London, and is the author of Absorption and Drug Development (2nd ed., Wiley, 2012). In 2021, the book was translated into Chinese, by translators affiliated with the China Food and Drug Administration. For nearly 50 years, he has been teaching, researching, and developing methods, instruments, and analysis software for the measurement of ionization constants, solubility, dissolution, and permeability of drugs. His accomplishments in the development of instrumentation include several well-known instruments that are or recently have been manufactured by leading companies in the instrument market, including Thermo Fisher Scientific, Sirius Analytical, and Pion Inc. He has over 200 technical publications in primary scientific journals and book chapters. He has written several comprehensive technical guides and is a co-inventor on six patents. He cofounded Sirius Analytical (UK) in 1989, pION Inc. (USA) in 1996, and founded in–ADME Research (New York City) in 2011. His other positions were at Orion Research, Syracuse University, UC Berkeley, and Caltech.
