Health Risk Assessment of 1,1,1-trichloroethane (MC) in California Drinking Water
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Page : 226 pages
File Size : 39,57 MB
Release : 1988
Category : Drinking water
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Author :
Publisher :
Page : 226 pages
File Size : 39,57 MB
Release : 1988
Category : Drinking water
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Author :
Publisher :
Page : 120 pages
File Size : 14,61 MB
Release : 1988
Category : Drinking water
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Author : United States. Environmental Protection Agency. Environmental Criteria and Assessment Office (Research Triangle Park, N.C.)
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Page : 182 pages
File Size : 27,46 MB
Release : 1985
Category : Air
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Page : 308 pages
File Size : 27,43 MB
Release : 1995
Category : 1,1,1-trichloroethane
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Author :
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Page : 192 pages
File Size : 43,10 MB
Release : 1988
Category : Chlorofluoromethane
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Publisher :
Page : 297 pages
File Size : 25,19 MB
Release : 1988
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Author : National Research Council
Publisher : National Academies Press
Page : 449 pages
File Size : 35,3 MB
Release : 2007-01-08
Category : Science
ISBN : 0309102839
Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.
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Page : 840 pages
File Size : 39,5 MB
Release : 1990
Category : Power resources
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Page : 184 pages
File Size : 47,65 MB
Release : 1988
Category : Chlorofluoromethane
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Author : Eula Bingham
Publisher : John Wiley & Sons
Page : 5872 pages
File Size : 49,34 MB
Release : 2012-07-31
Category : Science
ISBN : 0470410817
Featuring the improved format used in the 5th edition, this updated set presents, in logical groupings, comprehensive toxicological data for industrial compounds, including CAS numbers, physical and chemical properties, exposure limits, and biological tolerance values for occupational exposures, making it essential for toxicologists and industrial hygienists. This edition has about 40% new authors who have brought a new and international perspective to interpreting industrial toxicology, and discusses new subjects such as nanotechnology, flavorings and the food industry, reactive chemical control to comprehensive chemical policy, metalworking fluids, and pharmaceuticals.