Heme-Fe Proteins


Book Description

Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bioinorganic to solid state. This acclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.




Principles of Bioinorganic Chemistry


Book Description

The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance.




Peptide, Protein and Enzyme Design


Book Description

De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. - Continues the legacy of this premier serial with quality chapters on de novo enzyme design - Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field - Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism




Tetrapyrroles


Book Description

Excluding the biological polymers proteins, lipids and nucleic acids, modified tetrapyrroles are the biological molecules that have had the greatest impact on the evolution of life over the past 4 billion years. They are involved in a wide variety of fundamental processes that underpin central primary metabolism in all kingdoms of life, from photosynthesis to methanogenesis. Moreover, they bring colour into the world and it is for this reason that these compounds have been appropriately dubbed the ‘pigments of life’. To understand how and why these molecules have been so universally integrated into the life processes one has to appreciate the chemical properties of the tetrapyrrole scaffold and, where appropriate, the chemical characteristics of the centrally chelated metal ion. This book addresses why these molecules are employed in Nature, how they are made and what happens to them after they have finished their usefulness.




Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc


Book Description

This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.




The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins


Book Description

This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds. The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries. The authors represent a veritable Who's Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists. - Extremely distinguished list of authors - Multidisciplinary character – equally suitable for chemists and biochemists - Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.




Dioxygen-dependent Heme Enzymes


Book Description

This book highlights the many and varied catalytic activities of O2-dependent heme-iron enzymes, including monoxygenases and cytochrome P450, dioxygenases, oxidases and model heme systems required for postgraduate students and researchers in biochemistry and metallobiology.




Heme Biology: Heme Acts As A Versatile Signaling Molecule Regulating Diverse Biological Processes (Second Edition)


Book Description

This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction of the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. In the second edition, a new chapter is devoted to describe findings about heme uptake, transport, and trafficking of heme synthesis intermediates in mammals. Additionally, a chapter about the newly discovered roles of elevated heme biosynthesis and uptake in lung tumorigenesis is included.Heme Biology is unified and logical in presentation. It is well suited for students and professionals in life sciences who wish to know about the fascinating biology of heme and its usefulness in health and diseases. It may also be used as a reference book for advanced readers and researchers who are interested in heme biology. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary information for researchers to have an in-depth molecular understanding of heme biology and further their studies in this fascinating realm.




Iron-containing Enzymes


Book Description

Mononuclear iron containing enzymes are important intermediates in bioprocesses and have potential in the industrial biosynthesis of specific products. This book features topical review chapters by leaders in this field and its various sub-disciplines.




Heme Peroxidases


Book Description

Heme peroxidases are widely distributed in biological systems and are involved in a wide range of processes essential for life. This book provides a comprehensive single source of information on the various aspects of heme peroxidase structure, function and mechanism of action. Chapters written and edited by worldwide experts span a range of heme peroxidases from plants, yeast, bacteria and mammals. Discussed functions of peroxidases range from cell wall synthesis, synthesis of prostaglandins, role in drug suppression of tuberculosis, and antibacterial activity. Included is a discussion of peroxidases that also act as catalases and oxygenases. Heme Peroxidases serves as an essential text for those working in industry and academia in biochemistry and metallobiology.