Osteogenesis Imperfecta


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Alphaherpesviruses


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Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.







Tile & Till


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Senlin


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Type & Typo


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The Charnel Rose


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The House of Dust


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Punch


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Ordering the World


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The Sung Dynasty (960–1278) was a time of vast changes and new challenges in China. The growth of the urban and rural economics, population increase, the emergence of an educated elite, political and intellectual ferment, and threats from hostile neighbors are some of the forces that shaped the age. How did Sung statesmen and thinkers view the relation of state and society and the role of political action in solving society’s ills? The essays in Ordering the World explore contemporary ideas underlying policies, programs, and institutions of the period and examine attitudes toward history and sources of authority. Their findings have important implications for our understanding of the neo-Confucian movement in Sung history and of the Sung in the history of Chinese ideas about politics and social action. Contents: Introduction by Conrad Schirokauer and Robert P. Hymes “Su Hsun’s Pragmatic Statecraft,” by George Hatch “State Power and Economic Activism during the New Policies, 1068–1085,” by Paul J. Smith “Government, Society, and State,” by Peter K. Bol “Chu Hsi’s Sense of History,” by Conrad Schirokauer “Community and Welfare,” by Richard von Glahn “Charitable Estates as an Aspect of Statecraft in Southern Sung China,” by Linda Walton “Moral Duty and Self-Regulating Process in Southern Sung Views of Famine Relief,” by Robert P. Hymes “The Historian as Critic,” by John W. Chaffee “Wei Liao-weng’s Thwarted Statecraft,” by James T. C. Liu “Chen Te-hsiu and Statecraft,” by Wm. Theodore de Bary This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1993.