Aging, Death, and Human Longevity


Book Description

With the help of medicine and technology we are living longer than ever before. As human life spans have increased, the moral and political issues surrounding longevity have become more complex. Should we desire to live as long as possible? What are the social ramifications of longer lives? How does a longer life span change the way we think about the value of our lives and about death and dying? Christine Overall offers a clear and intelligent discussion of the philosophical and cultural issues surrounding this difficult and often emotionally charged issue. Her book is unique in its comprehensive presentation and evaluation of the arguments—both ancient and contemporary—for and against prolonging life. It also proposes a progressive social policy for responding to dramatic increases in life expectancy. Writing from a feminist perspective, Overall highlights the ways that our biases about race, class, and gender have affected our views of elderly people and longevity, and her policy recommendations represent an effort to overcome these biases. She also covers the arguments surrounding the question of the "duty to die" and includes a provocative discussion of immortality. After judiciously weighing the benefits and the risks of prolonging human life, Overall persuasively concludes that the length of life does matter and that its duration can make a difference to the quality and value of our lives. Her book will be an essential guide as we consider our social responsibilities, the meaning of human life, and the prospects of living longer.




Human Aging


Book Description

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. - Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging - Offers the ability to access cross-sectional knowledge more easily - Written by expert researchers in biogerontology who are actively involved in various fields within aging research




Ending Aging


Book Description

MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.




The Evening of Life


Book Description

Although philosophy, religion, and civic cultures used to help people prepare for aging and dying well, this is no longer the case. Today, aging is frequently seen as a problem to be solved and death as a harsh reality to be masked. In part, our cultural confusion is rooted in an inadequate conception of the human person, which is based on a notion of absolute individual autonomy that cannot but fail in the face of the dependency that comes with aging and decline at the end of life. To help correct the ethical impoverishment at the root of our contemporary social confusion, The Evening of Life provides an interdisciplinary examination of the challenges of aging and dying well. It calls for a re-envisioning of cultural concepts, practices, and virtues that embraces decline, dependency, and finitude rather than stigmatizes them. Bringing together the work of sociologists, anthropologists, philosophers, theologians, and medical practitioners, this collection of essays develops an interrelated set of conceptual tools to discuss the current challenges posed to aging and dying well, such as flourishing, temporality, narrative, and friendship. Above all, it proposes a positive understanding of thriving in old age that is rooted in our shared vulnerability as human beings. It also suggests how some of these tools and concepts can be deployed to create a medical system that better responds to our contemporary needs. The Evening of Life will interest bioethicists, medical practitioners, clinicians, and others involved in the care of the aging and dying. Contributors: Joseph E. Davis, Sharon R. Kaufman, Paul Scherz, Wilfred M. McClay, Kevin Aho, Charles Guignon, Bryan S. Turner, Janelle S. Taylor, Sarah L. Szanton, Janiece Taylor, and Justin Mutter




The Biology of Senescence


Book Description

The Biology of Senescence




Approaching Death


Book Description

When the end of life makes its inevitable appearance, people should be able to expect reliable, humane, and effective caregiving. Yet too many dying people suffer unnecessarily. While an "overtreated" dying is feared, untreated pain or emotional abandonment are equally frightening. Approaching Death reflects a wide-ranging effort to understand what we know about care at the end of life, what we have yet to learn, and what we know but do not adequately apply. It seeks to build understanding of what constitutes good care for the dying and offers recommendations to decisionmakers that address specific barriers to achieving good care. This volume offers a profile of when, where, and how Americans die. It examines the dimensions of caring at the end of life: Determining diagnosis and prognosis and communicating these to patient and family. Establishing clinical and personal goals. Matching physical, psychological, spiritual, and practical care strategies to the patient's values and circumstances. Approaching Death considers the dying experience in hospitals, nursing homes, and other settings and the role of interdisciplinary teams and managed care. It offers perspectives on quality measurement and improvement, the role of practice guidelines, cost concerns, and legal issues such as assisted suicide. The book proposes how health professionals can become better prepared to care well for those who are dying and to understand that these are not patients for whom "nothing can be done."




Epigenetics of Aging


Book Description

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.




Encyclopedia of Death and the Human Experience


Book Description

Death and dying and death-related behavior involve the causes of death and the nature of the actions and emotions surrounding death among the living. Interest in the varied dimensions of death and dying has led to the development of death studies that move beyond medical research to include behavioral science disciplines and practitioner-oriented fields. As a result of this interdisciplinary interest, the literature in the field has proliferated. This two-volume resource addresses the traditional death and dying–related topics but also presents a unique focus on the human experience to create a new dimension to the study of death and dying. With more than 300 entries, the Encyclopedia of Death and the Human Experience includes the complex cultural beliefs and traditions and the institutionalized social rituals that surround dying and death, as well as the array of emotional responses relating to bereavement, grieving, and mourning. The Encyclopedia is enriched through important multidisciplinary contributions and perspectives as it arranges, organizes, defines, and clarifies a comprehensive list of death-related perspectives, concepts, and theories. Key Features Imparts significant insight into the process of dying and the phenomenon of death Includes contributors from Asia,; Africa; Australia; Canada; China; eastern, southern, and western Europe; Iceland; Scandinavia; South America; and the United States who offer important interdisciplinary and cross-cultural perspectives Provides a special focus on the cultural artifacts and social institutions and practices that constitute the human experience Addresses death-related terms and concepts such as angel makers, equivocal death, end-of-life decision making, near-death experiences, cemeteries, ghost photography, halo nurses, caregiver stress, cyberfunerals, global religious beliefs and traditions, and death denial Presents a selective use of figures, tables, and images Key Themes Arts, Media, and Popular Culture Perspectives Causes of Death Conceptualization of Death, Dying, and the Human Experience Coping With Loss and Grief: The Human Experience Cross-Cultural Perspectives Cultural-Determined, Social-Oriented, and Violent Forms of Death Developmental and Demographic Perspectives Funerals and Death-Related Activities Legal Matters Process of Dying, Symbolic Rituals, Ceremonies, and Celebrations of Life Theories and Concepts Unworldly Entities and Events With an array of topics that include traditional subjects and important emerging ideas, the Encyclopedia of Death and the Human Experience is the ultimate resource for students, researchers, academics, and others interested in this intriguing area of study.




Between Zeus and the Salmon


Book Description

Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.




Lifespan


Book Description

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.