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Organ-on-a-Chip

Author : Marco Rasponi

Publisher : Humana

Page : 0 pages

File Size : 16,18 MB

Release : 2022-09-29

Category : Science

ISBN : 9781071616956

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Book Description

This book provides a collection of microphysiological systems employed for chemical/drug screening and strategies to mimic various physiological conditions. Chapters guide readers through Organ-on-a-Chip( OoC) platforms such as liver, intestine, blood-brain barrier, kidney, vessels, cardiac and skeletal muscles, articular joint, human fat. Additional chapters detail microfabrication technologies used to fabricate OoC devices such as, standard photo- and soft-lithography, techniques to fabricate membranes, and industrial-oriented fabrication methods.Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Organ-On-a Chip: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.



Organs-on-chips

Author : Yu-suke Torisawa

Publisher : MDPI

Page : 262 pages

File Size : 12,78 MB

Release : 2020-05-27

Category : Technology & Engineering

ISBN : 3039289179

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Book Description

Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have great potential to promote drug discovery and development, to model human physiology and disease, and to replace animal models for efficacy and toxicity testing. Recently, induced pluripotent stem (iPS) cells have been leveraged to develop organs-on-chips, which enable various types of organ models and disease models not possible with primary cells and cell lines. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) microdevices to mimic or control cellular microenvironment; (2) microdevices to evaluate interactions between different organ models; (3) microdevices to maintain iPS cells or iPSC-derived cells; and (4) sensors and techniques to evaluate drug efficacy or toxicity.



Organ-on-a-chip

Author : Julia Hoeng

Publisher : Academic Press

Page : 545 pages

File Size : 29,33 MB

Release : 2019-11-09

Category : Technology & Engineering

ISBN : 0128172037

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Book Description

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. - Includes case studies of other organs on a chip that have been developed and successfully used - Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine - Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip



Lab-on-a-Chip Fabrication and Application

Author : Margarita Stoytcheva

Publisher : BoD – Books on Demand

Page : 210 pages

File Size : 47,63 MB

Release : 2016-06-29

Category : Science

ISBN : 9535124579

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Book Description

The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.



Biochip Technology

Author : Jing Cheng

Publisher : CRC Press

Page : 453 pages

File Size : 38,95 MB

Release : 2003-09-02

Category : Science

ISBN : 0203305043

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Book Description

Biochip technology has experienced explosive growth in recent years and Biochip technology describes the basic manufacturing and fabrication processes and the current range of applications of these chips. Top scientists from the biochip industry and related areas explain the diverse applications of biochips in gene sequencing, expression monitoring, disease diagnosis, tumor examination, ligand assay and drug discovery.



Organ Manufacturing

Author : Xiaohong Wang

Publisher : Nova Science Publishers

Page : 0 pages

File Size : 38,43 MB

Release : 2015

Category : Artificial organs

ISBN : 9781634829571

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Book Description

This is the first time that human organs, such as the heart, liver, kidney, stomach, uterus, skin, lung, pancreas and breast can be manufactured automatically and precisely for clinical transplantation, drug screening and metabolism model establishment. Headed by Professor Xiaohong Wang (also the founder and director) in the Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, this group has focused on organ manufacturing for over ten years. A series of technical bottleneck problems, such as vascular and nerve system establishment in a construct, multiple cell types and material system incorporation, and stem cell sequential engagement, have been overcome one by one. Two technical approaches have been exploited extensively. One is multiple nozzle rapid prototyping (RP), additive manufacturing (AM), or three-dimension (3D) printing. The other is combined mold systems. More than 110 articles and 40 patents with a series of theories and practices have been published consequently. In the future, all the failed organs (including the brain) in the human body can be substituted easily like a small accessory part in a car. Everyone can get benefit from these techniques, which ultimately means that the lifespan of humans, therefore, can be greatly prolonged from this time point. This book examines the progress made in the field and the developments made by these researchers (and authors) in the field.



Microfluidics and Lab-on-a-Chip

Author : Andreas Manz

Publisher : Royal Society of Chemistry

Page : 307 pages

File Size : 16,48 MB

Release : 2020-09-24

Category : Science

ISBN : 1782628339

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Book Description

Responding to the need for an affordable, easy-to-read textbook that introduces microfluidics to undergraduate and postgraduate students, this concise book will provide a broad overview of the important theoretical and practical aspects of microfluidics and lab-on-a-chip, as well as its applications.



Stem Cells

Author : Christine L. Mummery

Publisher : Academic Press

Page : 446 pages

File Size : 14,59 MB

Release : 2014-05-23

Category : Science

ISBN : 0124115675

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Book Description

The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. - Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy - Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice - Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice



Biofabrication

Author : Gulden Camci-Unal

Publisher : Elsevier Inc. Chapters

Page : 36 pages

File Size : 37,6 MB

Release : 2013-03-18

Category : Medical

ISBN : 0128090510

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Book Description

Microscale hydrogels are potentially useful materials for controlling cellular behavior to mimic native microenvironments for tissue engineering applications. In this chapter, various fabrication techniques to generate microscale hydrogels and their applications in tissue engineering have been outlined. In addition, we provide examples of microscale hydrogels with different physical and chemical properties for generation of tissue constructs. Finally, we discuss potential future directions in fabrication of hydrogels to address challenges in tissue engineering. It is expected that these techniques will enable engineering of three-dimensional (3D) structures with controlled features for the formation of functional tissues and organs.



Basic Concepts on 3D Cell Culture

Author : Cornelia Kasper

Publisher : Springer Nature

Page : 252 pages

File Size : 23,50 MB

Release : 2021-06-09

Category : Medical

ISBN : 3030667499

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Book Description

This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is provided and insight into various aspects and challenges that researchers need to consider and face during culture of 3D cells is given. The reader will learn the importance of physiological cell, tissue and organ models and gains important knowledge on 3D analytics. This textbook deepens selected aspects of the textbook “Cell Culture Technology”, which also is published in this series, while offering extended insight into 3D cell culture. The concept of the textbook encompasses various lectures ranging from basics in cell cultivation, tissue engineering, biomaterials and biocompatibility, in vitro test systems and regenerative medicine. The textbook addresses Master- and PhD students interested and/or working in the field of modern cell culture applications and will support the understanding of the essential strategies in 3D cell culture and waken awareness for the potentials and challenges of this application.