IFM’99


Book Description

Formal methods have been established as the rigorous engineering methodology for the system development. Applying formal methods to a large and complex system development often requires the modelling of different aspects of such a system. For instance, complex systems (such as integrated avionics systems, engine control software) can involve functional and timing requirements that must be eventually implemented as executing code on a communicating distributed topology. This book contains the papers presented at the First International Workshop on Integrated Formal Methods, held at the University of York in June 1999. The conference provided a forum for the discussion of theoretical aspects of combing behavioural and state-based formalisms and practical solutions to the industrial problems of this approach.




Integrated Formal Methods


Book Description

This book constitutes the refereed proceedings of the Second International Conference on Integrated Formal Methods, IFM 2000, held in Dagstuhl, Germany in November 2000. The 22 revised full papers presented together with the abstracts of two invited talks were carefully reviewed and selected from 58 submissions. The papers are grouped together in topical sections on linking and extending notations, methodology, foundation of one formalism by another, semantics, and verification and validation.




Immunomodulating Drugs for the Treatment of Cancer


Book Description

Immunomodulating Drugs for the Treatment of Cancer provides a comprehensive resource for clinicians and researchers regarding immunomodulatory (IMiDs) drugs and their rapidly emerging role in cancer medicine. This new class of anticancer agents has made a tremendous impact on the treatment of patients with various malignant diseases, including blood cancers and several cancers of the solid organs. Their popularity in prescribing is based on several important characteristics including: (1) oral bioavailability, (2) non-chemotherapeutic, (3) extremely well-tolerated in all age groups, (4) ability to activate patient's own immune response against cancer, (5) ease of combination with other agents such as chemotherapy resulting in higher responses as well as (6) variability of anticancer activity.




Thomas' Hematopoietic Cell Transplantation, 2 Volume Set


Book Description

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.




Allogeneic Stem Cell Transplantation


Book Description

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.




Treatment of Multiple Myeloma and Related Disorders


Book Description

Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome.




DeVita, Hellman, and Rosenberg's Cancer


Book Description

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.




Formal Methods at the Crossroads. From Panacea to Foundational Support


Book Description

This volume is devoted to the 10th Anniversary Colloquium of UNU/IIST, the International Institute for Software Technology of the United Nations University, as well as to the memory of Armando Haeberer, who passed away while he was working on the preparation of this book in February 2003. The volume starts with a special paper by Tom Maibaum recollecting Armando Haeberer's life and work. The second part presents work done by members of UNU/IIST as well as a paper on the history of the institute. The subsequent topical sections present key contributions by leading researchers and thus assess the state of the art in software engineering and its engineering and scientific principles, from models to software, real-time systems, and verification. All in all, the book is a unique survey of the power and potential of formal methods in software engineering.




FME 2002: Formal Methods - Getting IT Right


Book Description

This volume contains the proceedings of the 2002 symposium Formal Methods th Europe (FME 2002). The symposium was the 11 in a series that began with a VDM Europe symposium in 1987. The symposia are traditionally held every 18 months. In 2002 the symposium was held at the University of Copenhagen, as part of the 2002 Federated Logic Conference (FLoC 2002), which brought - gether in one event seven major conferences related to logic in computer science, as well as their a?liated workshops, tutorials, and tools exhibitions. Formal Methods Europe (www.fmeurope.org) is an independent association which aims to stimulate the use of, and research on, formal methods for software development. FME symposia have been notably successful in bringing together a community of users, researchers, and developers of precise mathematical - thods for software development. The theme of FME 2002 was “Formal Methods: Getting IT Right”. The double meaning was intentional. On the one hand, the theme acknowledged the signi?cant contribution formal methods can make to Information Technology, by enabling computer systems to be described precisely and reasoned about with rigour. On the other hand, it recognized that current formal methods are not perfect, and further research and practice are required to improve their foundations, applicability, and e?ectiveness.




Feature Interactions in Telecommunications and Software Systems VI


Book Description

Typically, telecommunications services are implemented in software. Feature interaction is the term used to describe interference between services or features; most attention is given to cases where the interference is undesirable, ie. there is an incompatibility. In telecommunications, control and data is distributed and on such a large scale that software development is by numerous disjoint teams; by its nature, therefore, this software experienced the feature interaction problem first. But, while the workshop focuses on communications services, the subject has relevance to any domain where separate software entities control a shared resource.