Decisions of the Commission


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Fabry Disease


Book Description

Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.




Losing a Million Minds


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Lost Twin Cities


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1993 American Institute of Architects International Architecture Book Award




Public general laws


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European Elites and Ideas of Empire, 1917-1957


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Explores European civilisation as a concept of twentieth-century political practice and the project of a transnational network of European elites. This title is available as Open Access.




Advancing Oral Health in America


Book Description

Though it is highly preventable, tooth decay is a common chronic disease both in the United States and worldwide. Evidence shows that decay and other oral diseases may be associated with adverse pregnancy outcomes, respiratory disease, cardiovascular disease, and diabetes. However, individuals and many health care professionals remain unaware of the risk factors and preventive approaches for many oral diseases. They do not fully appreciate how oral health affects overall health and well-being. In Advancing Oral Health in America, the Institute of Medicine (IOM) highlights the vital role that the Department of Health and Human Services (HHS) can play in improving oral health and oral health care in the United States. The IOM recommends that HHS design an oral health initiative which has clearly articulated goals, is coordinated effectively, adequately funded and has high-level accountability. In addition, the IOM stresses three key areas needed for successfully maintaining oral health as a priority issue: strong leadership, sustained interest, and the involvement of multiple stakeholders from both the public and private sectors. Advancing Oral Health in America provides practical recommendations that the Department of Health and Human Services can use to improve oral health care in America. The report will serve as a vital resource for federal health agencies, health care professionals, policy makers, researchers, and public and private health organizations.




AIA Guide to the Twin Cities


Book Description

Get ready to discover the great architectural mecca that is Minneapolis and St. Paul. The first comprehensive, illustrated handbook of its kind, AIA Guide to the Twin Cities is the ultimate source to the architectural riches of the metropolitan area. Organized by neighborhood and featuring a wealth of sites--from the highest point on the Minneapolis skyline to the modest St. Paul bungalow vibrant with historical and architectural significance--this invaluable reference has it all: -Illuminating entries for more than 3,000 buildings -Behind-the-scenes details of the structures and their architects -Lively information about local history and regional styles -Highlights of important buildings nearly lost in time -Sixty easy-to-read maps that pinpoint the location of every structure -Dozens of planned walking and driving tours -Over 1,000 photos that illustrate significant buildings and features Retired Pioneer Press architecture critic Larry Millett has spent more than two decades researching and exploring the architectural heritage of the Twin Cities. Millett's AIA Guide to the Twin Cities is your ticket to the best tour in town. Sponsored in part by the American Institute of Architects Minnesota. Larry Millett has written extensively about Twin Cities architecture. His books include Lost Twin Cities, Twin Cities Then and Now, and Strange Days, Dangerous Nights (all MHS Press), as well as a series of mystery novels featuring Sherlock Holmes.