Innovative Medicine


Book Description

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.




The Leptin Boost Diet


Book Description

UNLEASH THE POWER OF LEPTIN When the hormone leptin blinds with receptors in your brain, it shuts down your appetite and speeds up your metabolism! FINALLY A DIET THAT WILL WORK FOR YOU On the Leptin Boost Diet, you will correct the hormonal imbalances that have made it impossible to lose weight on other diets and: •Develop a lean body •Maintain a healthy weight •Feel more energetic •Elevate your mood •Experience restful sleep •Sharpen your mental focus END CRAVINGS AND STOP FEELING HUNGRY When short of leptin, your brain mistakenly thinks your body is starving and sends signals telling you to eat more. The Leptin Boost Diet reserves both leptin deficiency in the bloodstream and leptin resistance in the brain, ensuring that you will finally feel full and stop overeating.




Leptin Diet


Book Description

Leptin Diet: Delicious Recipes for The Leptin Diet Leptin is the hormone which tells when to eat and when we do not need to take in food. Recent research suggest that Leptin Resistance is the underlying reason that so many people find it impossible to lose weight on a permanent basis. Rebuilding sensitivity to Leptin is not only simple but is possible for anybody. This book is designed to help you do exactly that! It contains background information on Leptin Resistance and also on how to successfully implement any diet. The book doesn't focus on cutting any type of food but, instead, on how to create a healthy, balanced diet which will help your body to do what it does (or should do) naturally! The recipes in the book have been gathered together with a focus of foods and meals which will help you to live a healthy life and will complement your body's own natural functions. The majority of the recipes should be simple for anybody to prepare, even for those with little experience in the kitchen. Leptin resistance is now considered to be one of the biggest contributing factor to weight problems and obesity. For those tackling these issues, this book could provide a perfect solution! Here Is A Preview Of What You'll Learn... What Leptin Resistance Is Current Thinking On Its Role In Weight Problems Recipes Designed To Encourage Your Body To Rebuild Its Sensitivity To Leptin




Obesity and Lipotoxicity


Book Description

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.




The Fat Resistance Diet


Book Description

No more counting carbs, calories, or fat grams! This revolutionary diet plan works with your hormones to curb your appetite, boost your metabolism, and take the pounds off for good! Cutting-edge research shows that losing weight is not about carbs, calories, or even willpower—it’s about a hormone called leptin, and how it functions in your body. Leptin is your body’s natural weight-loss mechanism: it curbs your appetite, jump-starts your metabolism, and when working properly makes you literally fat resistant—you will lose weight effortlessly and efficiently and never gain those pounds back. If you’re struggling to lose weight, chances are you are “leptin resistant”—your body no longer responds to leptin, making it impossible for you to slim down. The Fat Resistance Diet is the first and only eating plan designed specifically to combat leptin resistance and reprogram your body to start melting away the pounds. Using a breakthrough combination of anti-inflammatory and hormone-balancing foods, the three-phase regimen delivers: A loss of six to ten pounds in the first two weeks. A loss of at least two pounds a week thereafter. Fun, flavorful meals that make sticking with the plan a breeze. An easy maintenance program that keeps you fat resistant for life. With over 100 delicious recipes designed for maximum satisfaction and eating pleasure, the Fat Resistance Diet is the only diet you’ll ever need—a brand new way to eat that will transform your body into a lean, fat-fighting machine.




Mastering Leptin


Book Description

First published in 2002, Mastering Leptin was the first and most in-depth book explaining the hormone leptin and its relationship to obesity, difficult weight loss, yo-yo dieting, low energy, heart disease, low thyroid, stress eating, food cravings, and hormonal imbalance. Mastering Leptin cuts through the confusion of countless ways to eat and provides individuals with a workable lifestyle for permanent weight loss. Renowned leptin expert, Byron Richards analyzes over 8,500 leptin-related scientific studies and brings amazing findings to the public in an easy-to-understand format. Readers loved the first and second editions of Mastering Leptin due to the fascinating connections made between leptin, weight loss, energy, hormone balance, and disease. Thousands of people have been able to lose weight and keep it off. The third edition is newly edited and updated. It is much more than a diet book. It is a true guide for healthy weight loss, improved energy, and optimum health.




Neural Regulation of Metabolism


Book Description

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.




Gut Hormones


Book Description




Leptin Reset


Book Description

Discover How To Fix Your Fat Hormones And Reboot Your Fat Burning Engine Into First Gear Again Has Your Fat Loss Stalled Even Though You've Cut Your Calories Even More And Work Out Harder Than Ever?Leptin could very well be the most important hormone you have never heard about when trying to reach your fat loss goals. If your goal is to lose fat, get lean without killing yourself then it's time to get your Leptin levels in order.The longer your body stays in a calorie deficit, the more your leptin levels and metabolic rate decrease. It's a catch-22 situation. It doesn't matter how much you increase your exercise or decrease your calories, if your metabolism slows, then all fat loss stops.Conversely, if you constantly eat above your caloric maintenance levels, then your body can become leptin resistant making it harder for you to lose fat.Isn't It Time You Became Smarter Than Your Fat?If you want to win the fat loss game, you're going to have to outsmart your fat. The Leptin Reset is specifically designed specifically to combat leptin resistance by using specific combinations of hormone-balancing foods to get your hormones working for you again instead of against you.Here's what you'll get: A 14-day kick-starter program that can help you get your fat loss back on the fast track. An easy to follow meal plans that keep your leptin levels balanced and happy Delicious Recipes that are rich in hormone healing foods and powerful phytonutrients, that makes the program a breeze to stick to. The 3 foods you should never eat when it comes to healthy hormones... The long term effects of leptin resistance and how they effect your overall health and happiness The 4 clear signs that you are leptin resistant The most common ingredient found in foods that throws your leptin levels out of whack Much, much more! The sooner you get your leptin levels managed, the faster you can begin showing off your new lean body!




Leptin and Reproduction


Book Description

The isolation of leptin in 1994 and its characterization as a factor influencing appetite, energy balance, and adiposity, immediately thrust the polypeptide into the rapidly growing body of literature centered on the physiology of obesity. The growing clinical awareness of obesity as a major health risk in developed societies dovetailed perfectly with any of a number of roles that leptin might play in this abenant physiological condition. Almost unnoticed amidst the excitement generated by early leptin publications was the suggestion that the "fat hormone" might also regulate a wide range of systems and events important to reproduction, including pubertal development, gonadal endocrinology, fettility, and pregnancy. Recognizing this potential, a relatively small cadre of researchers began to examine leptin specifically as a reproductive hormone, thus creating a new and fertile field of investigation. Interest in this area has since gained momentum and an increased number of participants have now made significant contributions to our understanding of many leptin-related mechanisms that are relevant to reproductive biology. Leptin and Reproduction is the first major volume to specifically address leptin as a reproductive hormone and closely examines the advances made in the short time since this field of interest developed. Preeminent researchers ti'om many of the subdisciplines working within this area present a welcomed compendium of the wealth of related literature and voice novel interpretations of cun'ent advances.