Quantitative Trait Loci


Book Description

In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.




Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci


Book Description

Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes. - Focuses on the generation of an effective immune response to invading pathogens - Contains contributions from leading authorities - Informs and updates on all the latest developments in the field of immunology




Problems of Locus Solved by Mechanisms Theory


Book Description

This book reports on an original approach to problems of loci. It shows how the theory of mechanisms can be used to address the locus problem. It describes the study of different loci, with an emphasis on those of triangle and quadrilateral, but not limited to them. Thanks to a number of original drawings, the book helps to visualize different type of loci, which can be treated as curves, and shows how to create new ones, including some aesthetic ones, by changing some parameters of the equivalent mechanisms. Further, the book includes a theoretical discussion on the synthesis of mechanisms, giving some important insights into the correlation between the generation of trajectories by mechanisms and the synthesis of those mechanisms when the trajectory is given, and presenting approximate solutions to this problem. Based on the authors’ many years of research and on their extensive knowledge concerning the theory of mechanisms, and bridging between geometry and mechanics, this book offers a unique guide to mechanical engineers and engineering designers, mathematicians, as well as industrial and graphic designers, and students in the above-mentioned fields alike.




Quantitative Trait Loci Analysis in Animals


Book Description

Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This advanced-level textbook covers all the statistical methods that have been used or proposed for detection and analysis of QTL and marker- and gene- assisted selection in animal genetics and breeding, as well as new advances that have revolutionized the field since the first edition.




Solid Geometry


Book Description




Schubert Varieties and Degeneracy Loci


Book Description

Schubert varieties and degeneracy loci have a long history in mathematics, starting from questions about loci of matrices with given ranks. These notes, from a summer school in Thurnau, aim to give an introduction to these topics, and to describe recent progress on these problems. There are interesting interactions with the algebra of symmetric functions and combinatorics, as well as the geometry of flag manifolds and intersection theory and algebraic geometry.







Classification of Mixed-font Alphabetics by Characteristic Loci


Book Description

A method is described for designing by computer a binary decision tree that, using the coefficients determined by the learning process, would speed up the classification of patterns.




One-Locus and Multi-Locus Theory and Recombination


Book Description

The book will benefit a reader with a background in physical sciences and applied mathematics interested in the mathematical models of genetic evolution. In the first chapter, we analyze several thought experiments based on a basic model of stochastic evolution of a single genomic site in the presence of the factors of random mutation, directional natural selection, and random genetic drift. In the second chapter, we present a more advanced theory for a large number of linked loci. In the third chapter, we include the effect of genetic recombination into account and find out the advantage of sexual reproduction for adaptation. These models are useful for the evolution of a broad range of asexual and sexual populations, including virus evolution in a host and a host population.




Selection in One- and Two-Locus Systems


Book Description

Most of these notes were presented as part of a two-quarter course on theoretical population genetics at The University of Chicago. Almost all the students were either undergraduates in mathematics or graduate students in the biological sciences. The only prerequisites were calculus and matrices. As is done in these notes, biological background and additional mathematical techniques were covered when they were required. I have included the relevant problems assigned in the course. My aim in these notes is to formulate the various models fairly generally, making the biological assumptions quite explicit, and to perform the analyses relatively rigorously. I hope the choice and treatment of topics will enable the reader to understand and evaluate detailed analyses of specific models and applications in the literature. No attempt has been made to review the literature or to assign credit. Most of the references are to papers directly germane to the subjects and approaches covered here. Frequency of reference is not intended to reflect proportionate contribution. I am very grateful to Professor James F. Crow for helpful comments and to Mrs. Adelaide Jaffe for her excellent typing. I thank the National Science Foundation for its support (Grant No. DEB76-01550).