Mechanisms of Cooperativity and Allosteric Regulation in Proteins
Author : Max F. Perutz
Publisher : CUP Archive
Page : 124 pages
File Size : 33,7 MB
Release : 1990-05-17
Category : Medical
ISBN : 9780521386487
Allostery
Author : Aron W. Fenton
Publisher : Humana Press
Page : 0 pages
File Size : 15,21 MB
Release : 2011-11-04
Category : Science
ISBN : 9781617793332
Book Description
Despite considerable variability within the scientific community, allosteric regulation can best be defined functionally as how a macromolecule binds one ligand differently when a second ligand is or is not pre-bound to the macromolecule, which constitutes a vital aspect of protein structure/function. In Allostery: Methods and Protocols, expert researchers in the field provide key techniques to investigate this biological phenomenon. Focusing on heterotropic systems with some coverage of homotropic systems, this volume covers the monitoring of allosteric function, allosteric conformational changes, and allosteric changes in protein dynamics/sub-population distribution, as well as topics such as macromolecular and ligand engineering of allosteric functions and computational aids in the study of allostery. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Allostery: Methods and Protocols aids scientists in continuing to study ligand-induced, through-protein effects on protein function (ligand binding/catalysis), a phenomenon that is well recognized through the history of the life sciences and very poorly understood at the molecular level.
Protein Allostery in Drug Discovery
Author : Jian Zhang
Publisher : Springer Nature
Page : 384 pages
File Size : 42,41 MB
Release : 2019-11-09
Category : Medical
ISBN : 9811387192
Book Description
The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
Allosteric Regulatory Enzymes
Author : Thomas W. Traut
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 11,74 MB
Release : 2007-09-11
Category : Science
ISBN : 0387728910
Book Description
This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Allosteric Enzymes
Author : Guy Herve
Publisher : CRC Press
Page : 269 pages
File Size : 15,16 MB
Release : 2020-11-25
Category : Science
ISBN : 1000098826
Book Description
This book compiles detailed information concerning a dozen of the best known allosteric enzymes, and so allows the comparison of their regulatory mechanisms and the confrontation of these mechanisms with the theoretical models. Stimulating and unexpected ideas emerge from these comparisons and emphasize the importance of developing various methods of investigation such as crystallography, X-ray solution scattering, and the study of fast movements in proteins and site-directed mutagenesis. This book is addressed to students and researchers interested in structure-function relationship in proteins, enzymology and metabolic regulation. It is also a basis for teaching.
Regulation of Tissue Oxygenation, Second Edition
Author : Roland N. Pittman
Publisher : Biota Publishing
Page : 117 pages
File Size : 14,95 MB
Release : 2016-08-18
Category : Medical
ISBN : 1615047212
Book Description
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Biochemistry and Oral Biology
Author : A. S. Cole
Publisher : Butterworth-Heinemann
Page : 570 pages
File Size : 29,31 MB
Release : 2014-06-28
Category : Science
ISBN : 1483183718
Book Description
Biochemistry and Oral Biology presents a unique exposition of biochemistry suitable for dental students. It discusses the structural basis of metabolism and the general principles of nutrition. It addresses the soft tissues, hard tissues, and the biology of the mouth. Some of the topics covered in the book are the free radical production; scope of biochemistry; characteristics of atoms; structure and properties of water; molecular building materials; ionization of proteins; affinity chromatography of proteins; structural organization of globular proteins; classification of enzymes; and biochemically important sugar derivatives. The naturally occurring fatty acids are fully covered. The nucleic acid components are discussed in detail. The text describes in depth the energy equivalents of different nutrients. The physiological effects of dietary fiber vitamin D deficiency are completely presented. A chapter is devoted to the alternative methods of fluoride administration and description of vitamins. The book can provide useful information to dental students, and researchers.
Comprehensive Biophysics
Author :
Publisher : Academic Press
Page : 3533 pages
File Size : 32,47 MB
Release : 2012-04-12
Category : Science
ISBN : 0080957188
Book Description
Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource
Nucleotide Metabolism
Author : J. Frank Henderson
Publisher : Academic Press
Page : 323 pages
File Size : 49,78 MB
Release : 2014-06-28
Category : Science
ISBN : 1483261158
Book Description
Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.
Protein Actions: Principles and Modeling
Author : Ivet Bahar
Publisher : Garland Science
Page : 337 pages
File Size : 35,61 MB
Release : 2017-02-14
Category : Science
ISBN : 1351815016
Book Description
Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
