Methods of External Hyperthermic Heating


Book Description

The development of equipment capable of producing and monitoring safe, effective and predictable hyperthermia treatments represents a major challenge. The main problem associated with any heating technique is the need to adjust and control the distribution of absorbed power in the tissue during treatment. Power distribution is considered adequate only when tumor tissue can be maintained at the required hyperthermic levels while, at the same time, healthy tissue is not overheated. This problem is particularly crucial when external heating devices are used to produce hyperthermia. Ex ternal hyperthermia refers to those methods which supply heat to tumor tissue in an external, noninvasive manner, as opposed to internal hyperther mia by which heat is supplied to tumor tissue in situ. Until recently, most of the technical developments and clinical trials of ther motherapy for superficial and deep tumors have been based on elec tromagnetic systems. Presently, there is increasing interest in the use of ultra sound to accomplish these goals. Electromagnetic techniques of external thermotherapy include radiative, capacitive, and, to a lesser extent, inductive procedures. Recent designs for radiative applicators have incorporated microstrip structures. These have the advantage of being compact and lightweight compared with dielectrically loaded waveguide applicators.




Thermoradiotherapy and Thermochemotherapy


Book Description

Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.




Oncothermia: Principles and Practices


Book Description

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.




Temperature Regulation


Book Description

MANY aspects of physiology are best understood in terms of bodily reactions to environmental stress, and temperature is one of the most often encountered stress factors in the environment. The responses to temperature can involve practically all of the organ systems of the body and it is for this reason that the study of the regulation of body temperatures represents one of the finest examples of complex reaction integrated by the nervous and endocrine systems, and hence of the principles of biological control. Thus, while thermoregulation offers an abundance of opportunities for the individual who likes to specialize in depth, it is an ideal type of physiology for those who prefer to think of the functioning of the body as whole. This book is written primarily for the undergraduate, but I hope also that some students may find time to read it, before embarking on a university course, as an introduction to some of the ideas that will be encountered in the more detailed study of the biological sciences, including medicine. I have tried to discuss the evidence for important ideas, since this is fundamental to the scientific method, and have been particularly concerned to avoid the use of the sort of technical jargon that gives a spurious impression of authority while in reality creating confusion out of what is in essence simple.




Thermoradiotherapy and Thermochemotherapy


Book Description

Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy of ionizing radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Triple modality (thermo-chemo-radiotherapy) or other treatment combinations have not been fully evaluated and may demonstrate extended clinical applications in the future. Problems remain with regard to maximizing the effects of hyperthermia as they are influenced by a variety of external and intrinsic factors including bloodflow, microenvironment etc. While the previous volume has summarized more theoretical aspects of hyper thermia, i.e. biology, physiology and physics, the present volume compiles the current knowledge relative to the clinical applications of hyperthermia in combina tion with radiation therapy and/or chemotherapy, providing a comprehensive over view of its use in cancer management.




MRI-Guided Focused Ultrasound Surgery


Book Description

MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr




Physics of Thermal Therapy


Book Description

The field of thermal therapy has been growing tenaciously in the last few decades. The application of heat to living tissues, from mild hyperthermia to high-temperature thermal ablation, has produced a host of well-documented genetic, cellular, and physiological responses that are being researched intensely for medical applications, particularly fo




Biomedical Technology and Devices Handbook


Book Description

Concise yet comprehensive, the Biomedical Technology and Devices Handbook illuminates the equipment, devices, and techniques used in modern medicine to diagnose, treat, and monitor human illnesses. With topics ranging from the basic procedures like blood pressure measurement to cutting-edge imaging equipment, biological tests, and genetic engineeri




Cancer Nanotechnology


Book Description

Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors-a




Biomedical Engineering Handbook


Book Description

Category Biomedical Engineering Subcategory Contact Editor: Stern