Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis


Book Description

Molecular biology has provided a tool with which problems in cellular differentiation can be answered. Recombinant DNA technology has been used to obtain quantities of the erythropoietic hormone, erythropoietin. The availability of the hormone has provided a much-needed impetus in learning how erythropoiesis is controlled. Knowledge of the genetic components, transcription and translation of the erythropoietin gene and finally the release of the mature hormone under various physiological conditions should be forthcoming in the near future. This volume will give the reader some indication as to the different aspects of erythropoiesis. They include the regulation of production of the hormone under normal and abnormal conditions, ontogeny and cellular interactions and the assay of the hormone itself.




Textbook of Nephro-Endocrinology


Book Description

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. - Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems - Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work - Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field




Oxygen Sensing


Book Description

The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.







Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology


Book Description

Anemia is a frequent complication of cancer and its treatment. A number of clinical studies shows that the impact of anemia is much greater than previously thought. Beyond clinical symptoms, anemia significantly impairs physical and metabolic functions as well as patients' activity, well-being and quality of life. Life expectancy is also affected. In this book, written by a group of outstanding international experts, the current knowledge on anemia in cancer and its treatment with rhEPO is presented. Future developments are also discussed. Based on a broad spectrum of topics, the book describes the scientific and clinical aspects of anemia in various fields of oncology and gives diagnostic and therapeutic recommendations on when and how to use rhEPO.




Veterinary Hematology


Book Description

Combining essential hematology content with the diagnostic features of an atlas, Veterinary Hematology: A Diagnostic Guide and Color Atlas delivers all the information you need to accurately assess and diagnose the blood diseases of common domestic animals — including dogs, cats, horses, cattle, sheep, goats, pigs, and llamas. This all-in-one resource utilizes a clinically-oriented and user-friendly approach to guide you through the processes of selecting relevant diagnostic tests, collecting and preparing samples, interpreting sample results, and determining their clinical significance. High-resolution photomicrographs, full-color illustrations, and excellent schematic drawings, tables, and quick-reference algorithms help you clearly visualize these concepts and procedures. Two books in one gives you the information of a user-friendly, clinical textbook and the diagnostic features of a color atlas in a single reference. Practical, clinically-relevant text is comprehensive and yet concise in its delivery of vital information such as: Principles and procedures that are employed in recognizing normal, abnormal, and artifactual features of blood and bone marrow samples and developing accurate diagnoses Common cytochemical stains and summary charts for interpretation Sample collection, staining procedures, and diagnostic techniques Differentiating features of malignant and benign hematologic disorders Miscellaneous cells and blood parasites and their significance in the evaluation of blood smears Hematopoietic and non-hematopoietic neoplasms High- resolution photomicrographs and excellent schematic drawings, tables, boxes and quick-reference algorithms aid your understanding of basic clinical concepts and differential diagnostic considerations. Over 800 full-color illustrations help you clearly visualize the concepts and clinical features of the blood and bone marrow — from normal cell maturation to the development of various pathologies.




Hypoxia


Book Description

Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.




Receptors


Book Description

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.




Pocket Companion to Brenner and Rector's The Kidney


Book Description

Pocket Companion to Brenner and Rector's The Kidney distills the essential clinical information from the latest edition of the seminal text on kidney diseases and their management. Michael R. Clarkson, Ciara Magee, and Barry M. Brenner detail the key pathophysiologic, diagnostic, and treatment issues in clinical nephrology, including interventional nephrology, endocrine aspects of kidney disease, and plasmapheresis. - Diagnose, treat, and manage both common and uncommon disorders. - Find clinical knowledge quickly and easily thanks to convenient tables throughout the text. - Choose the best option of the many techniques available through discussions of indications for laboratory tests and imaging studies.Enhance your clinical acumen with coverage of new topics such as risk factors and kidney disease, nephron endowment, interventional nephrology, plasmapheresis, xenotransplantation, stem cells in renal biology and medicine, and more. Stay current thanks to two new sections—Epidemiology and Risk Factors in Kidney Disease and Frontiers in Kidney Disease—that include topics such as stem cell and genomics.




Molecular, Cellular, and Developmental Biology of Erythropoietin and Erythropoiesis


Book Description

Recombinant DNA technology has allowed the cloning, sequencing and large-scale production of human erythropoietin, which is now used in therapy for the anaemia of renal disease. In addition, there are many ongoing clinical trials in which recombinant human erythropoietin is being investigated. The availability of the recombinant reagent has added great impetus to all areas of erythropoetin and erythropoiesis research. This multidisciplinary work brings together investigators from many fields who discuss past, present and future research in this area. The science here is primarily experimental and should be of interest to biochemists, experimental haematologists, pharmacologists, clinical haematologists and nephrologists.