Molecular and Functional Insights Into the Pulmonary Vasculature


Book Description

This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.




Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension


Book Description

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.




Fetal and Neonatal Lung Development


Book Description

Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.




How Tobacco Smoke Causes Disease


Book Description

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.




MRI of the Lung


Book Description

During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.




Molecular Pathology


Book Description

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. - Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease - Explains the practice of "molecular medicine and the translational aspects of molecular pathology - Teaches from the perspective of "integrative systems biology - Enhanced digital version included with purchase




Genesis, Pathophysiology and Management of Venous and Lymphatic Disorders


Book Description

Genesis, Pathophysiology Management of Venous Diseases is the must-have resource on venous disease. The book bridges the gap between basic science and clinical medicine, covering the history of venous surgery, the lymphatic system and anatomy, pathophysiology of various venous disease, etiology, clinical manifestations and diagnosis, management, and medical and surgical treatment options. It also places attention on genetic studies and pharmacological analysis of various anticoagulants which are widely used in treating venous diseases and deep vein thrombosis and highlights the importance of microscopic venous valves and their pathology in both normal and disease condition. The breadth of topics covered makes this reference suitable for a range of professionals in phlebolymphology and cardiology, including medical students, practicing clinicians, surgeons, researchers, radiologists, bioengineers, and more. Provides complete, up-to-date developments in the field of phlebolymphology, including the history of venous surgery, lymphatic system and anatomy, pathophysiology of various venous disease, and more Includes new etiological and pathophysiological concepts and the latest outlooks and trends in the management of CVD Written in an easy-to-read manner, the book includes tables, figures, clinical photographs and medical illustrations to aid understanding




Pulmonary Circulation: From Basic Mechanisms To Clinical Practice


Book Description

This new book with 35 chapters is a comprehensive account of the important features of the pulmonary circulation which will appeal to (1) clinical and non-clinical students who want a broad-based introduction to the subject, (2) postgraduates involved in or contemplating research on the pulmonary circulation, (3) specialists in chest medicine, cardiology and intensive and critical care whose clinical work concerns diseases affecting the pulmonary blood vessels.Pulmonary circulation is well illustrated with 132 figures, 43 tables and learning points highlighted at the end of each chapter. There are two main sections: “Basic Mechanisms” and “Clinical Practice”. All the important features of the pulmonary circulation are reviewed — genetics, cell biology, vascular remodelling, anatomy, physiology, pharmacology, pulmonary hypertension, pulmonary oedema, etc.




The Pulmonary Endothelium


Book Description

The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals – specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.




Cardiothoracic Critical Care E-Book


Book Description

This new bedside manual guides you through all the practical aspects of managing patients following cardiothoracic surgery and critically ill cardiology patients. Primarily designed to use in cardiothoracic intensive care units and coronary care units, it covers the perioperative management for the full range of cardiothoracic surgical procedures, the management of complications, and related issues. Core topics in cardiothoracic critical care, such as hemodynamic instability, arrhythmias, bleeding, and mechanical cardiac support, are afforded broad coverage. Also included are sections on advanced ventilatory techniques and veno-venous ECMO for treating severe respiratory failure, as well as nutritional support, treating and preventing infection, renal failure, and care of the dying patient. Concisely written and featuring liberal use of illustrations as well as an integrated, tightly edited style, and a limited number of key references, this volume will become your reference of choice for the care of of cardiothoracic surgery patients and critically ill cardiology patients. Find information quickly with concisely written text. Get a more complete picture with extensive illustrations. Focus on just the information you need using a a limited number of key references. Navigate the complexities of critical care for a fulll range of cardiothoracic surgery patients with in-depth coverage of perioperative care, management of complications, and more.