Molecular Cytopathology


Book Description

This book reviews the current applications of molecular tools in cytopathology and provides a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different subspecialities of diagnostic pathology. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future and reviews the technical challenges in applying and validating molecular tools in liquid-based cytologic materials. Molecular Cytopathology will serve as a valuable resource for cytopathologists, cytotechnologists, pathology trainees, and clinicians with an interest in molecular applications in cytopathology.




Molecular Applications in Cytology


Book Description

This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader to benefit from their experiences by providing a valuable tool for the implementation of these techniques in daily practice. Though the use of molecular techniques is well established in surgical biopsies, to date they are not widely used in connection with cytological material. However, in some fields like lung cancer or aspirates from the pancreas and biliary tract the only available material for diagnosis is the cytological preparation a fact that has created a need for the standardization of molecular techniques on cytology.




Comprehensive Cytopathology E-Book


Book Description

This best-selling book provides you with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. The book takes a systemic approach and covers the recognized normal and abnormal cytological findings encountered in a particular organ. Appropriate histopathological correlations and a consideration of the possible differential diagnosis accompany the cytological findings. The book is lavishly illustrated, making it the perfect practical resource for daily reference in the laboratory. Provides an accessible guide to diagnostic investigation and screening. Includes a summary of major diagnostic criteria and discusses the pitfalls and limitations of cytology. Utilizes a consistent chapter structure to make finding the answers you need quick and easy. Provides updates to crucial chapters to keep you on top of the latest diagnosis and techniques. Incorporates differential diagnosis tables for easy comparison/contrast of diagnoses. Offers more than 1800 full-color images depicting a full range of normal and abnormal findings. Discusses new concepts on molecular basis of neoplasia. Explores the role of cytogenetics in cancer development.




Diagnostic Cytopathology


Book Description

Diagnostic Cytopathology provides the clinician with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. The book takes a systemic approach and will cover the recognised normal and abnormal cytological findings encountered in a particular organ. Appropriate histopathological correlations and a consideration of the possible differential diagnosis accompany the cytological findings. The book is heavily illustrated to ensure that it will be a practical resource for daily reference in the laboratory. A uniformity of basic chapter structure will expedite the clinician's search for answers to any query. in-depth bench book that covers everyday diagnostic work. Provides the clinician with an accessible guide to diagnostic investigation and screening. Cytologic findings closely related to histology. Provides the general diagnostic pathologist in the interpretation and recognition of tissue samples. Each chapter provides a summary of major diagnostic criteria and discusses the pitfalls and limitations of cytology. Enables the clinician to use cytology services more effectively. Major revisions of the following chapters: Mesotheliomas, Malignant Breast Tumours, Lymph Nodes, The Pathogenesis of Cervical Neoplasia, Cervical intraepithelial neoplasia and Squamous Carcinoma of the Cervix. Brand new chapter on Automation which is increasingly important in cervical screening. Additional material on Thin Core Biopsy technique which is increasingly used in Breast Screening Program. Inclusion of new genetic markers in immunohistochemistry increasingly important in non-gynaecological areas. With 47 additional contributors.




Atlas of Thyroid Cytopathology on Liquid-Based Preparations


Book Description

This illustrated volume serves as a handy guide to diagnostic fine needle aspiration (FNA) cytology of thyroid on liquid-based preparations (LBP). It is intended to be a ready resource to accurately diagnose thyroid lesions on LBP using key cytomorphologic features. Key cytologic differential diagnosis, gross, and histopathological correlations accompany the cytological findings. The Atlas of Thyroid Cytopathology on Liquid-Based Preparations is lavishly illustrated with color images of various thyroid diseases that should familiarize pathologists with the differences between conventional smears and LBP, and between the two commonly used LBPs. Authored by leaders in the field, this atlas provides clear, concise, and practical guidance pertaining to cytomorphology and the implications of thyroid FNA diagnoses for patient care in this era of precision medicine.




Diagnostic Pathology


Book Description

Part of the highly regarded Diagnostic Pathology series, this updated volume by Drs. Dina R. Mody, Michael J. Thrall, and Savitri Krishnamurthy, is a visually stunning, easy-to-use reference covering all aspects of cytology, including gynecologic, non-gynecologic exfoliative, fine-needle aspiration, and imaging. An abundance of high-quality images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow who works with ever-smaller tissue samples for diagnosis and molecular testing. Essential knowledge in all areas of cytopathology, including clinical, radiologic, cytopathological features, immunohistochemical, and molecular correlates where applicable Time-saving reference features include bulleted text, a variety of tables, key facts in each chapter, annotated images, pertinent references, and an extensive index Thoroughly updated content throughout, incorporating significant changes in cytopathology classifications, reporting systems, and science New coverage of the Bethesda 2014 reporting terminology for gynecologic cytology and updates on HPV testing and management guidelines; updates on the Milan System for Reporting of Salivary Gland Cytology with risk stratification; the Paris System for Reporting Urinary Cytology; and updates on the Bethesda 2017 reporting terminology for thyroid cytology Coverage of state-of-the-art immunohistochemistry and molecular markers as applicable to the practice of cytology and anatomic pathology, as well as current information on lab operations, regulatory mandates, quality improvement, and risk reduction Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.




Cell and Tissue Based Molecular Pathology E-Book


Book Description

This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! Offers detailed discussions on today’s technologies to help you select the best test for case evaluation. Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field. Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.




Diagnostic Cytopathology E-Book


Book Description

This edition stresses not just the diagnostic cytological features of the various conditions encountered, but also the diagnostic pitfalls and the grey areas between so as to enable the reader to give more evidence-based reports. In recognition of their rapid expansion, there are new chapters on recent technological developments and on the cytodiagnosis of childhood tumours. A special section on the importance of multidisciplinary team meetings that include the cytopathologist as a core member of the team has also been included at the end of each chapter. As active members of this team, cytopathologists can define their role in the management pathway and thus bring the patient and the microscope together as never before. The full text can be accessed online and images downloaded via Expert Consult.




Molecular Diagnostics in Cytopathology


Book Description

Molecular diagnostics are increasingly used to help guide targeted therapy in solid organ tumors and hematologic malignancies. A large proportion of molecular testing is performed on limited-volume samples obtained via minimally invasive techniques, such as fine needle aspiration. Increasingly, cytopathologists play an essential role in this process, both in the triage of specimens during rapid on-site evaluation and in the evaluation of archival samples to determine suitability for ancillary testing. Therefore, it is imperative that practicing cytopathologists stay abreast of up-to-date diagnostic, prognostic, and predictive ancillary tests that can be used on limited cytologic material. This is a challenge since the landscape of known genomic alterations is constantly evolving and the subsequent set of testing options is ever expanding. The proposed text will provide a user-friendly quick-reference handbook to serve as a useful resource for practicing pathologists and laboratory personnel dealing with, and interested in, this evolving field of molecular cytopathology. Essential components to be presented include: 1) pre-analytic factors that affect sample selection and evaluation; 2) specimen preparation to maximize confidence in results; 3) interpretation of results; 4) potential limitations; and 5) workflow algorithms. In addition, specific disease specific molecular testing details will be outlined to provide the reader with resources for quick reference. All chapters will be written by experts in their fields and will include the most up-to-date scientific and clinical information. Molecular Diagnostics in Cytopathology will be of value to Cytopathologists, Cytotechnologists, Cytotechnology students, Cytopathology fellows, Surgical pathologists, Pathology residents and fellows, Molecular Pathologists, Molecular pathology fellows, Molecular technologists, as well as Translational researchers with an interest in molecular cytopathology.




Differential Diagnosis in Cytopathology Book and Online Bundle


Book Description

This updated edition remains the essential text for pathologists seeking to make accurate diagnoses from the vast number of differentials.