Molecular Genetic Testing in Surgical Pathology


Book Description

Written by experts from Washington University School of Medicine, this text is a thorough review of the specific molecular genetic techniques that can provide diagnostically useful molecular genetic information on tissue samples—including cytogenetics, fluorescence in situ hybridization (FISH), PCR, electrophoresis and hybridization analysis, DNA sequence analysis, and microarrays. The first part of the book describes each technique, indicates its advantages, disadvantages, capabilities, and limitations, and systematically addresses sensitivity and specificity issues. Subsequent chapters, organized by organ system, detail the specific applications of these tests in surgical pathology. More than 150 full-color and black-and-white illustrations complement the text.




Molecular Genetics of Colorectal Neoplasia


Book Description

Molecular Genetics of Colorectal Neoplasia A Primer for the Clinician provides the latest information on the genetics of colorectal cancer within a context of basic genetics, describing the subject in understandable language and making it clinically relevant. In this way, clinicians can become familiar with genetic terms and techniques related to colorectal neoplasia, providing a background upon which to build an appreciation of future advances and an ability to include them in the practicalities of patient care. This edition is intended for the healthcare provider or industry concerned with colorectal neoplasia: including general and colorectal surgeons, pathologists, oncologists, gastroenterologists, internal medicine and family practice physicians, nurses, geneticists, counsellors, registry co-ordinators, epidemiologists, and statisticians.




Molecular Genetics of Cancer


Book Description

Since the first volume was published, there has been significant success in isolating genes responsible for particular cancers as well as a major improvement in our understanding of the molecular events leading to tumors. This book explores possible genetic treatments that can suppress cancer cells that have formed tumors and it presents the details of the isolation and characterization of new human cancer genes that have recently been identified. Molecular Genetics of Cancer, 2E is an essential book for anyone involved in cancer research and the search for a cure.




Principles and Practice of Surgical Oncology


Book Description

Principles and Practice of Surgical Oncology uniquely emphasizes a multidisciplinary, integrated approach to the treatment of solid tumors. It presents treatment strategies that combine surgery with preoperative or postoperative adjunctive chemotherapy, hormonal therapy, and/or radiation therapy to achieve optimal outcome. The book features contributions from surgeons, basic scientists, pathologists, radiologists, radiation therapists, and medical oncologists and offers a comprehensive presentation of genetics, molecular biology, pathogenesis, and multimodal therapeutic approaches. A unique feature of the book is a commentary following each chapter, which describes alternative approaches and discusses controversial areas of current therapy. A companion Website will offer the fully searchable text with images.




Genetics for Surgeons


Book Description

Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).




Surgical Oncology


Book Description

How should surgeons deal with cancer patients? The cornerstone of effective treatment is a multidisciplinary collaboration between many specialties in which surgeons are not only concerned about operative accessibility and technique but rather have a deep understanding of the fundamental biology of the malignancy they are dealing with and appreciate the reach of multi-modal treatment. This handbook is a practical reference for today's surgeons who actively manage cancer patients in both the acute and out-patient setting. It covers all the key areas, from initial presentation and diagnosis, investigation and staging, to active discussion in collaborative multidisciplinary cancer network meetings, operative management, post-operative care, and long term surveillance and palliation. Drawing together all the varied guidelines and source materials that form the basis of this complex subject, it is the first surgical oncology text that provides instant access to detailed clinical algorithms and operative techniques covering the wide range of cancers that general surgeons encounter, from GI tract to breast and endocrine cancers. Consistently sourced from current evidence based guidelines with a concise summary of underlying pathology and molecular biology, Surgical Oncology will enable the reader to knowledgably manage cancer patients from initial assessment to long term surveillance. It is an essential accompaniment for all higher surgical trainees from MRCS to the exit FRCS and EBSQ exams, and will be particularly useful for trainees rotating between surgical subspecialties, as well as having wide appeal to other members of the multidisciplinary team.




Molecular Genetics and Colorectal Neoplasia


Book Description

Understanding the genetic background of colorectal cancer iskey to optimal patient management. Genetics plays a role in diagnosis, screening, therapy, prognosis and surveillance of this disease as ithelps define the behaviour and natural history of particular types oftumors. Much of the molecular genetics behind colorectal cancer iscomplex and confusing, especially to busy practitioners who do nothave the time or opportunity to keep abreast of developments."Molecular Genetics of Colorectal Neoplasia A Primer for theClinician" provides the latest information on the genetics ofcolorectal cancer within a context of basic genetics, describing thesubject in understandable language and making it clinically relevant.In this way, clinicians can become familiar with genetic terms andtechniques related to colorectal neoplasia, providing a backgroundupon which to build an appreciation of future advances and an abilityto include them in the practicalities of patient care.This edition is intended for the healthcare provider or industryconcerned with colorectal neoplasia: including general and colorectalsurgeons, pathologists, oncologists, gastroenterologists, internalmedicine and family practice physicians, nurses, geneticists, counsellors, registry co-ordinators, epidemiologists, andstatisticians.




The Genetics of Cancer


Book Description

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.




Molecular Surgical Pathology


Book Description

Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a “first knowledge base” in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.