Pandora's DNA


Book Description

2015 ALA Notable Book Would you cut out your healthy breasts and ovaries if you thought it might save your life? That's not a theoretical question for journalist Lizzie Stark's relatives, who grapple with the horrific legacy of cancer built into the family DNA, a BRCA mutation that has robbed most of her female relatives of breasts, ovaries, peace of mind, or life itself. In Pandora's DNA, Stark uses her family's experience to frame a larger story about the so-called breast cancer genes, exploring the morass of legal quandaries, scientific developments, medical breakthroughs, and ethical concerns that surround the BRCA mutations, from the troubling history of prophylactic surgery and the storied origins of the boob job to the landmark lawsuit against Myriad Genetics, which held patents on the BRCA genes every human carries in their body until the Supreme Court overturned them in 2013. Although a genetic test for cancer risk may sound like the height of scientific development, the treatment remains crude and barbaric. Through her own experience, Stark shows what it's like to live in a brave new world where gazing into a crystal ball of genetics has many unintended consequences.




Building Genetic Medicine


Book Description

A comparative study of genetic testing for breast and ovarian cancer in the United States and Britain that shows the importance of national context in the development and use of science and technology even in an era of globalization. In Building Genetic Medicine, Shobita Parthasarathy shows how, even in an era of globalization, national context is playing an important role in the development and use of genetic technologies. Focusing on the development and deployment of genetic testing for breast and ovarian cancer (known as BRCA testing) in the United States and Britain, Parthasarathy develops a comparative analysis framework in order to investigate how national “toolkits” shape both regulations and the architectures of technologies and uses this framework to assess the implications of new genetic technologies. Parthasarathy argues that differences in the American and British approaches to health care and commercialization of research led to the establishment of different BRCA services in the two countries. In Britain, the technology was available through the National Health Service as an integrated program of counseling and laboratory analysis, and was viewed as a potentially cost-effective form of preventive care. In the United States, although BRCA testing was initially offered by a number of providers, one company eventually became the sole provider of a test available to consumers on demand. Parthasarathy draws lessons for the future of genetic medicine from these cross-national differences, and discusses the ways in which comparative case studies can inform policy-making efforts in science and technology.




Star Trek: Myriad Universes #2: Echoes and Refractions


Book Description

It's been said that for any event, there are an infinite number of possible outcomes. Our choices determine which outcome will follow, and therefore all possibilities that could happen do happen across countless alternate realities. In these divergent realms, known history is bent, like white light through a prism -- broken into a boundless spectrum of what-might-have-beens. But in those myriad universes, what might have been...is what actually happened. THE CHIMES AT MIDNIGHT: In a continuum where Spock died during childhood, an Andorian named Thelin became Captain Kirk's stalwart friend and first officer. But at the moment of Khan's final defeat, history takes an even stranger turn, and the emerging potential of Project Genesis is revealed as the galaxy's greatest hope...and its most ominous threat. A GUTTED WORLD: Terrorist Kira Nerys -- from a Bajor that was never liberated -- may hold the key to winning a war that has engulfed half the galaxy. But with the Romulans and the Klingons at each other's throats, and the Federation pulled into the conflict, even victory may not bring salvation. BRAVE NEW WORLD: Dr. Noonien Soong's dream has been realized: androids are now woven inextricably into the fabric of the Federation, revolutionizing Starfleet and transforming the quality of humanoid life. But when Soong's long-missing breakthrough creation, Data, mysteriously resurfaces, civilization reaches a crossroads that could lead to a bright new future, or to ruin.




Mammography and Beyond


Book Description

Each year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure. Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible. This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more. Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.




Genetics and the Behavior of Domestic Animals


Book Description

Behavior is shaped by both genetics and experience--nature and nurture. This book synthesizes research from behavioral genetics and animal and veterinary science, bridging the gap between these fields. The objective is to show that principles of behavioral genetics have practical applications to agricultural and companion animals. The continuing domestication of animals is a complex process whose myriad impacts on animal behavior are commonly under-appreciated. Genetic factors play a significant role in both species-specific behaviors and behavioral differences exhibited by individuals in the same species. Leading authorities explore the impact of increased intensities of selection on domestic animal behavior. Rodents, cattle, pigs, sheep, horses, herding and guard dogs, and poultry are all included in these discussions of genetics and behavior, making this book useful to veterinarians, livestock producers, laboratory animal researchers and technicians, animal trainers and breeders, and any researcher interested in animal behavior. - Includes four new chapters on dog and fox behavior, pig behavior, the effects of domestication and horse behavior - Synthesizes research from behavioral genetics, animal science, and veterinary literature - Broaches fields of behavior genetics and behavioral research - Includes practical applications of principles discovered by behavioral genetics researchers - Covers many species ranging from pigs, dogs, foxes, rodents, cattle, horses, and cats




Genomics of Rare Diseases


Book Description

Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. - Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes - Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions - Explores opportunities for novel therapeutics - Features chapter contributions from leading researchers and clinicians




Are We Slaves to our Genes?


Book Description

Genetic differences can influence differences in our human behaviours, but only occasionally undermine the reality of our free will.




Star Trek: Myriad Universes #1: Infinity's Prism


Book Description

It's been said that for any event, there are an infinite number of possible outcomes. Our choices determine which outcome will follow, and therefore all possibilities that could happen do happen across countless alternate realities. In these divergent realms, known history is bent, like white light through a prism -- broken into a boundless spectrum of what-might-have-beens. But in those myriad universes, what might have been...is what actually happened. A Less Perfect Union: More than a hundred years after the Terra Prime movement achieved its dream of an isolationist Earth, humanity is once again at a fork in the river of history...and the path it follows may ultimately be determined by the voice of a single individual: the sole surviving crewmember of the first Starship Enterprise.™ Places of Exile: Midway through Voyager's journey across the galaxy, Captain Kathryn Janeway and Commander Chakotay must choose whether to brave a deadly war zone or abandon their quest for home. But an attack by Species 8472 cripples the ship, and the stranded crew must make new choices that will reshape their destinies...and that of the Delta Quadrant itself. Seeds of Dissent: Khan victorious! Almost four centuries after conquering their world, genetically enhanced humans dominate a ruthless interstellar empire. But the warship Defiance, under its augmented commander, Princeps Julian Bashir, makes a discovery that could shake the pillars of his proud civilization: an ancient sleeper ship from Earth named the Botany Bay.




The Genetic Lottery


Book Description

A provocative and timely case for how the science of genetics can help create a more just and equal society In recent years, scientists like Kathryn Paige Harden have shown that DNA makes us different, in our personalities and in our health—and in ways that matter for educational and economic success in our current society. In The Genetic Lottery, Harden introduces readers to the latest genetic science, dismantling dangerous ideas about racial superiority and challenging us to grapple with what equality really means in a world where people are born different. Weaving together personal stories with scientific evidence, Harden shows why our refusal to recognize the power of DNA perpetuates the myth of meritocracy, and argues that we must acknowledge the role of genetic luck if we are ever to create a fair society. Reclaiming genetic science from the legacy of eugenics, this groundbreaking book offers a bold new vision of society where everyone thrives, regardless of how one fares in the genetic lottery.




Mobilizing Mutations


Book Description

With every passing year, more and more people learn that they or their young or unborn child carries a genetic mutation. But what does this mean for the way we understand a person? Today, genetic mutations are being used to diagnose novel conditions like the XYY, Fragile X, NGLY1 mutation, and 22q11.2 Deletion syndromes, carving out rich new categories of human disease and difference. Daniel Navon calls this form of categorization “genomic designation,” and in Mobilizing Mutations he shows how mutations, and the social factors that surround them, are reshaping human classification. Drawing on a wealth of fieldwork and historical material, Navon presents a sociological account of the ways genetic mutations have been mobilized and transformed in the sixty years since it became possible to see abnormal human genomes, providing a new vista onto the myriad ways contemporary genetic testing can transform people’s lives. Taking us inside these shifting worlds of research and advocacy over the last half century, Navon reveals the ways in which knowledge about genetic mutations can redefine what it means to be ill, different, and ultimately, human.