Neuro-Oncology Unveiled: A Comprehensive Guide to Brain Cancer


Book Description

Neuro-Oncology Unveiled: A Comprehensive Guide to Brain Cancer offers readers an unparalleled deep dive into the intricate world of brain tumors. This treatise, meticulously crafted by experts in the fields of oncology and biochemistry, serves as an essential resource for both medical professionals and those personally affected by a brain cancer diagnosis. From the historical evolution of our understanding of brain tumors to the latest advancements in treatment, this book covers it all. Delve into the cellular anatomy of the brain, explore the biochemical pathways that can lead to cancer, and understand the genetic and epigenetic factors that play a role in tumorigenesis. With detailed chapters on diagnostic techniques, ranging from advanced neurological assessments to cutting-edge imaging, readers will gain insights into the tools that are shaping the future of brain cancer diagnosis and treatment. But this treatise goes beyond the scientific. It delves into the holistic aspects of brain cancer care, discussing the role of nutrition, mind-body practices, and alternative therapies. It also addresses the emotional and psychological challenges faced by patients and their families, offering guidance on navigating the healthcare system, understanding insurance nuances, and seeking support. With a special focus on pediatric brain tumors, metastatic brain tumors, and the ethical implications of genetic testing and editing, this book ensures a holistic understanding of brain cancer from multiple perspectives. Whether you're a healthcare professional seeking a comprehensive resource, a patient looking for guidance, or a caregiver hoping to better support a loved one, Neuro-Oncology Unveiled is an invaluable companion on your journey through the complexities of brain cancer.




Re-Irradiation: New Frontiers


Book Description

This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.




Pediatric Neuro-oncology


Book Description

“The editors...have done an outstanding job of presenting...complex information in a lucid manner – this book is a must-read for the global community of aspiring students and neuro-oncology practitioners.” Amar Gajjar, MD in the Foreword This is a succinct introduction to pediatric neuro-oncology. It summarizes the key advances in molecular biology that have helped transform this rapidly evolving field and provides up-to-date coverage of major and emerging treatment modalities as well as supportive care. Separate chapters present each kind of pediatric brain cancer and its diagnosis and treatment. As more children survive brain cancer, the importance of quality of life issues and helping survivors to cope with the neuropsychological impact and long-term effects of current therapies has come into sharper focus; these topics are also addressed in the book, as are palliative care and pediatric neuro-oncology in countries with limited resources. The book is aimed at trainees and practitioners who seek an up-to-date text in pediatric neuro-oncology that is both comprehensive and concise.




The Human Hypothalamus


Book Description

The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders. - Discusses the importance of the hypothalamus in human growth and development - Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders - Includes metabolic and eating disorders - Identifies mechanisms of disease action and etiology - Provides best practice information for assessment and treatment




An Introduction to Machine Learning


Book Description

Just like electricity, Machine Learning will revolutionize our life in many ways – some of which are not even conceivable today. This book provides a thorough conceptual understanding of Machine Learning techniques and algorithms. Many of the mathematical concepts are explained in an intuitive manner. The book starts with an overview of machine learning and the underlying Mathematical and Statistical concepts before moving onto machine learning topics. It gradually builds up the depth, covering many of the present day machine learning algorithms, ending in Deep Learning and Reinforcement Learning algorithms. The book also covers some of the popular Machine Learning applications. The material in this book is agnostic to any specific programming language or hardware so that readers can try these concepts on whichever platforms they are already familiar with. Offers a comprehensive introduction to Machine Learning, while not assuming any prior knowledge of the topic; Provides a complete overview of available techniques and algorithms in conceptual terms, covering various application domains of machine learning; Not tied to any specific software language or hardware implementation.




Essentials of Writing Biomedical Research Papers. Second Edition


Book Description

Provides immediate help for anyone preparing a biomedical paper by givin specific advice on organizing the components of the paper, effective writing techniques, writing an effective results sections, documentation issues, sentence structure and much more. The new edition includes new examples from the current literature including many involving molecular biology, expanded exercises at the end of the book, revised explanations on linking key terms, transition clauses, uses of subheads, and emphases. If you plan to do any medical writing, read this book first and get an immediate advantage.




Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book


Book Description

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.




Neuro-oncology


Book Description

The second edition of Neuro-Oncology: The Essentials presents a comprehensive, highly readable introduction to the fundamental science and core clinical concepts for successfully managing common problems in neuro-oncology. Tightly focused chapters provide up-to-date systematic coverage of biology, imaging, surgery, radiation, chemotherapy, and biological concepts. The book addresses specific tumor types in separate chapters, providing detailed discussion of background, incidence, clinical features, management, surgical approaches, recurrence, and outcomes. Highlights: Pearls, pitfalls, controversies, and special considerations in textboxes - ideal for rapidly reviewing key points More than 250 photographs and illustrations demonstrate important concepts This book is an invaluable reference for neurosurgeons, neurologists, oncologists, residents and fellows in these specialties, as well as for students.




Brain Tumors


Book Description

Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities. Stay up to date with the latest developments in the field, including management of malignant gliomas; functional brain mapping; neurogenetics and the molecular biology of brain tumors; biologic and gene therapies; and much more. Apply the expert's best practices with their key points. The expert guidance of Drs. Kaye and Laws allows you to effectively deal with the increasing incidence of brain tumors, from diagnosis to surgical and radiotherapeutic management.




High-Grade Gliomas


Book Description

This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such “breakthrough” in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).