Author : David R. Riddle
Publisher : CRC Press
Page : 413 pages
File Size : 20,8 MB
Release : 2007-04-19
Category : Medical
ISBN : 1420005529
Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Author : Jean de Vellis
Publisher : Springer Science & Business Media
Page : 513 pages
File Size : 28,56 MB
Release : 2001-11-06
Category : Medical
ISBN : 1592591051
A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated activation of astrocytes and microglia and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier.
Author : Brian D. Gulbransen
Publisher : Biota Publishing
Page : 72 pages
File Size : 11,65 MB
Release : 2014-07-01
Category : Medical
ISBN : 1615046615
The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography
Author : Firas H. Kobeissy
Publisher : CRC Press
Page : 718 pages
File Size : 13,21 MB
Release : 2015-02-25
Category : Medical
ISBN : 1466565993
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author : Lindsay Biga
Publisher :
Page : pages
File Size : 25,53 MB
Release : 2019-09-26
Category :
ISBN : 9781955101158
A version of the OpenStax text
Author : J. Gordon Betts
Publisher :
Page : 0 pages
File Size : 26,42 MB
Release : 2013-04-25
Category :
ISBN : 9781947172807
Author : K Warner Schaie
Publisher : Academic Press
Page : 436 pages
File Size : 14,21 MB
Release : 2010-12-21
Category : Psychology
ISBN : 0123808839
The Handbook of the Psychology of Aging, Seventh Edition, provides a basic reference source on the behavioral processes of aging for researchers, graduate students, and professionals. It also provides perspectives on the behavioral science of aging for researchers and professionals from other disciplines. The book is organized into four parts. Part 1 reviews key methodological and analytical issues in aging research. It examines some of the major historical influences that might provide explanatory mechanisms for a better understanding of cohort and period differences in psychological aging processes. Part 2 includes chapters that discuss the basics and nuances of executive function; the history of the morphometric research on normal brain aging; and the neural changes that occur in the brain with aging. Part 3 deals with the social and health aspects of aging. It covers the beliefs that individuals have about how much they can control various outcomes in their life; the impact of stress on health and aging; and the interrelationships between health disparities, social class, and aging. Part 4 discusses the emotional aspects of aging; family caregiving; and mental disorders and legal capacities in older adults. - Contains all the main areas of psychological gerontological research in one volume - Entire section on neuroscience and aging - Begins with a section on theory and methods - Edited by one of the father of gerontology (Schaie) and contributors represent top scholars in gerontology
Author : Bente Pakkenberg
Publisher : Frontiers Media SA
Page : 110 pages
File Size : 41,18 MB
Release : 2019-07-25
Category :
ISBN : 2889458806
Author : Stephen Bondy
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 10,97 MB
Release : 2010-09-02
Category : Medical
ISBN : 1607616025
Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Author : Patrick R. Hof
Publisher : Academic Press
Page : 712 pages
File Size : 14,28 MB
Release : 2010-05-22
Category : Psychology
ISBN : 0080954057
A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008). The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers. This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology. - The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention - Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves - Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries) - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.) - Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers - Heavily illustrated with over 100 color figures
