› › Nonsegmented Negative Strand Viruses

Negative Strand RNA Virus

Author : Ming Luo

Publisher : World Scientific

Page : 323 pages

File Size : 50,5 MB

Release : 2011

Category : Medical

ISBN : 9814317233

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Book Description

Ch. 1. Overview of negative-strand RNA viruses / Biao He -- ch. 2. Rhabdovirus entry into the host cell / Aurelie Albertini and Yves Gaudin -- ch. 3. Virus entry : parainfluenza viruses / Masato Tsurudome -- ch. 4. What controls the distinct VSV RNA synthetic processes of replication and transcription? / Gail Williams Wertz, Summer E. Galloway and Djamila Harouaka -- ch. 5. mRNA capping by vesicular stomatitis virus and other related viruses / Tomoaki Ogino and Amiya K. Banerjee -- ch. 6. Structural disorder within the measles virus nucleoprotein and phosphorprotein : functional implications for transcript and replication / Sonia Longhi -- ch. 7. Biochemical and structural insights into vesicular stomatitis virus transcription / Amal A. Rahmeh and Sean P.J. Whelan -- ch. 8. Transcription of vesicular stomatitis virus RNA genome / Debasis Panda and Asit K. Pattnaik -- ch. 9. Assembly of vesicular stomatitis virus / Ming Luo, Todd J. Green and Z. Hong Zhou -- ch. 10. Paramyxovirus budding mechanisms / Megan S. Harrison, Takemasa Sakaguchi and Anthony P . Schmitt -- ch. 11. Virus-host interaction by members of the family rhabdoviridae and filoviridae / Douglas S. Lyles -- ch. 12. Paramyxovirus and rig-like helicases : a complex molecular interplay driving innate immunity / Denis Gerlier -- ch. 13. The molecular and cellular biology of emerging bunyaviruses / John N. Barr -- ch. 14. Ebolaviruses : what we know and where we are on potential therapeutics / Peter Halfmann, Gabriele Neumann and Yoshihiro Kawaoak



Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics

Author : Yoshihiro Kawaoka

Publisher : Springer Science & Business Media

Page : 354 pages

File Size : 11,14 MB

Release : 2013-04-17

Category : Medical

ISBN : 366206099X

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Book Description

Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.



Molecular Virology

Author : Susanne Modrow

Publisher : Springer

Page : 0 pages

File Size : 30,27 MB

Release : 2013-09-18

Category : Science

ISBN : 9783642207174

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Book Description

The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.



Viruses and Human Disease

Author : Ellen G. Strauss

Publisher : Elsevier

Page : 476 pages

File Size : 10,23 MB

Release : 2007-09-21

Category : Medical

ISBN : 0080553168

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Book Description

Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss' virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. - Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information - Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia - Further reading sections at the end of each chapter make it easy find key references - World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text



Sendai Virus Vector

Author : Yoshiyuki Nagai

Publisher : Springer Science & Business Media

Page : 218 pages

File Size : 17,77 MB

Release : 2014-01-31

Category : Medical

ISBN : 4431545565

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Book Description

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.



Viral Polymerases

Author : Satya Prakash Gupta

Publisher : Academic Press

Page : 498 pages

File Size : 42,15 MB

Release : 2018-10-29

Category : Science

ISBN : 0128154233

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Book Description

Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. - Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition - Analyzes the structure-activity relationships of inhibitors of each viral polymerase - Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets



Plant Virology

Author : Roger Hull

Publisher : Academic Press

Page : 1119 pages

File Size : 37,18 MB

Release : 2013-10-31

Category : Science

ISBN : 0123848725

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Book Description

The seminal text Plant Virology is now in its fifth edition. It has been 10 years since the publication of the fourth edition, during which there has been an explosion of conceptual and factual advances. The fifth edition of Plant Virology updates and revises many details of the previous edition while retaining the important earlier results that constitute the field's conceptual foundation. Revamped art, along with fully updated references and increased focus on molecular biology, transgenic resistance, aphid transmission, and new, cutting-edge topics, bring the volume up to date and maintain its value as an essential reference for researchers and students in the field. - Thumbnail sketches of each genera and family groups - Genome maps of all genera for which they are known - Genetic engineered resistance strategies for virus disease control - Latest understanding of virus interactions with plants, including gene silencing - Interactions between viruses and insect, fungal, and nematode vectors - Contains over 300 full-color illustrations



Peste des Petits Ruminants Virus

Author : Muhammad Munir

Publisher : Springer

Page : 0 pages

File Size : 48,66 MB

Release : 2016-08-23

Category : Medical

ISBN : 9783662523087

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Book Description

This book offers a timely and comprehensive review of essential research on Peste des Petits Ruminants Virus (PPRV), ranging from its historical distribution, molecular epidemiology, genome structure, viral proteins, immunity, viral pathogenesis, clinical and molecular diagnosis to advances in vaccine developments and future challenges. PPRV, a Rinderpest-like virus, is the causative agent of one of the most rapidly emerging viral diseases among domestic small ruminants, and the host spectrum has now been expanded to wild small ruminants and camels. With the global eradication of the first livestock disease, Rinderpest, attention is now turning to repeating the procedure for PPR. Each of the book’s 13 chapters is dedicated to a specific topic, providing up-to-date literature and discussions by renowned scientists who have made seminal contributions in their respective fields of expertise. Special emphasis has been placed on the analysis of different global efforts to eradicate PPR. This book offers a valuable reference source for virologists, field veterinarians, infection and molecular biologists, immunologists, scientists in related fields and veterinary school libraries.



Measles Virus Nucleoprotein

Author : Sonia Longhi

Publisher : Nova Publishers

Page : 180 pages

File Size : 18,66 MB

Release : 2007

Category : Medical

ISBN : 9781600216299

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Book Description

Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.



SARS, MERS and other Viral Lung Infections

Author : David S. Hui

Publisher : European Respiratory Society

Page : 148 pages

File Size : 11,45 MB

Release : 2016-06-01

Category : Medical

ISBN : 1849840709

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Book Description

Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.