Nuclear Localization of Growth Factors and of Monoclonal Antibodies


Book Description

Nuclear Localization of Growth Factors and of Monoclonal Antibodies focuses on how an additional class of chromatin receptors is directly involved in mediation of the action of growth factors on the gene regulation level. The book describes a new intracellular pathway of growth factors and presents methods for identifying nuclear antigens with an epitopic homology of the cell surface antigens. It teaches how to distinguish monoclonal antibodies that penetrate the cell and localize in the nucleus from those that act only on the cell surface. New light is shed on the mechanisms of malignant transformation, and new approaches to developing anti-cancer and anti-HIV drugs are covered. The book will be important for oncologists, biochemists, cell biologists, pharmaceutical researchers, investigative pathologists, neurochemists, and immunologists.




Nuclear Signaling Pathways and Targeting Transcription in Cancer


Book Description

At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.




Oral Precancer


Book Description

Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions. Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oral cancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development. Written and edited by prominent researchers in the field, Oral Precancer: Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more From start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions.




Cumulative Subject Index


Book Description

This Series provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The Series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.




Signaling Pathways in Squamous Cancer


Book Description

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.







Leong's Manual of Diagnostic Antibodies for Immunohistology


Book Description

Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.




Drug Discovery and Design


Book Description

Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.







Hormones Growth Factors & Oncogenes


Book Description

This text examines the hormones and peptide growth factors involved in the regulation of metabolism, growth and differentiation in metazoan organisms and proto-oncogene expression. Investigates protein products of some proto-oncogenes for involvement in the transductional and post-transductional and mechanisms of hormones and peptide growth factors.