Author : OECD
Publisher : OECD Publishing
Page : 20 pages
File Size : 28,67 MB
Release : 2010-07-23
Category :
ISBN : 9264070885
This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that ...
Author : Laura Robinson
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 19,98 MB
Release : 2018-11-05
Category : Science
ISBN : 1118882075
Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.
Author : Leslie R. Rudnick
Publisher : CRC Press
Page : 1855 pages
File Size : 49,68 MB
Release : 2020-01-29
Category : Science
ISBN : 1351655736
Highlighting the major economic and industrial changes in the lubrication industry since the first edition, Synthetics, Mineral Oils, and Bio-Based Lubricants: Chemistry and Technology, Third Edition highlights the major economic and industrial changes in the lubrication industry and outlines the state of the art in each major lubricant application area. Chapters cover the use of lubricant fluids, growth or decline of market areas and applications, potential new applications, production capacities, and regulatory issues, including biodegradability, toxicity, and food production equipment lubrication. The highly-anticipated third edition features new and updated chapters including those on automatic and continuously variable transmission fluids, fluids for food-grade applications, oil-soluble polyalkylene glycols, functional bio-based lubricant base stocks, farnesene-derived polyolefins, estolides, bio-based lubricants from soybean oil, and trends in construction equipment lubrication. Features include: Contains an index of terms, acronyms, and analytical testing methods. Presents the latest conventions for describing upgraded mineral oil base fluids. Considers all the major lubrication areas: engine oils, industrial lubricants, food-grade applications, greases, and space-age applications Includes individual chapters on lubricant applications—such as environmentally friendly, disk drive, and magnetizable fluids—for major market areas around the globe. In a single, unique volume, Synthetics, Mineral Oils, and Bio-Based Lubricants: Chemistry and Technology, Third Edition offers property and performance information of fluids, theoretical and practical background to their current applications, and strong indicators for global market trends that will influence the industry for years to come.
Author : Rakesh Kumar Tekade
Publisher : Elsevier
Page : 754 pages
File Size : 33,69 MB
Release : 2023-03-23
Category : Medical
ISBN : 044315841X
Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research. - Examines toxicological risk assessment in drug research - Discusses toxicity mechanisms - Covers risk assessment and the use of omics and computational technologies in mechanistic and predictive toxicology - Offers clinical interventions and managed care as a result of toxic injury and acute poisoning
Author : OECD
Publisher : OECD Publishing
Page : 26 pages
File Size : 17,91 MB
Release : 2007-10-15
Category :
ISBN : 9264067396
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
Author : OECD
Publisher : OECD Publishing
Page : 31 pages
File Size : 36,45 MB
Release : 2007-10-15
Category :
ISBN : 9264067353
This Test Guideline is designed to assess the effects of prolonged exposure to sediment-associated chemicals on the reproduction and the biomass of the endobenthic oligochaete Lumbriculus variegatus (Müller). The method is described for static test ...
Author : Christian Surber
Publisher : Karger Medical and Scientific Publishers
Page : 420 pages
File Size : 27,9 MB
Release : 2021-10-25
Category : Medical
ISBN : 3318066087
In the early 20th century, tanned skin was associated with good health. However, people began to protect themselves against potential overexposure to avoid sunburns. Around 1945, the first sunscreen products became available. In the years to follow, a vast number of different sunscreen filters and frameworks regulating filter substances and preparations, and methods characterizing sunscreen products were developed. The perception regarding the tasks of sunscreen products changed several times – initially it was promoted as a lifestyle product, then as a skin cancer preventive means, and more recently also for anti-aging. Different purposes and the widespread use of these products have led to myriad studies and a wealth of information. In this volume, the editors present a current collection of information analyzing and discussing issues related to sunscreen products and their use. These include challenges regarding the ideal sunscreen product including filter selection and formulation issues, measurement methods, performance characterization, safety, and regulatory issues. Further papers address topics related to the use of sunscreen products in everyday life, in vulnerable cohorts and outdoor workers. Controversial topics such as environmental effects of sunscreen products and the risks and benefits of UV radiation in the context of skin cancer, vitamin D and cardiovascular and metabolic health are also covered.
Author :
Publisher :
Page : 120 pages
File Size : 21,64 MB
Release : 1989
Category : Halocarbons
ISBN :
Author : OECD
Publisher : OECD Publishing
Page : 244 pages
File Size : 43,92 MB
Release : 2004-10-07
Category :
ISBN : 9264017984
The OECD Guidelines for the Testing of Chemicals are a collection of internationally agreed methods for testing the safety of chemicals and chemical preparations, including pesticides and industrial chemicals. This 2005 update contains 11 new and 3 revised guidelines.
Author : Joseph Tarradellas
Publisher : CRC Press
Page : 406 pages
File Size : 41,12 MB
Release : 1996-12-23
Category : Science
ISBN : 9781566701341
Soils are receptacles for a wide range of hazardous chemicals generated by human activities. Whether or not this contamination is deliberate, accurate toxicity assessments are important for health and economic reasons. Soil Ecotoxicology discusses the sources, fate, and transport of hazardous chemicals in soils. The fate (biodegradation and modeling) and the potential impacts of pesticides on soil ecosystems are emphasized, and methodologies for performing toxicity assessments are provided.
