Author : OECD
Publisher : OECD Publishing
Page : 13 pages
File Size : 45,8 MB
Release : 2015-07-28
Category :
ISBN : 9264242791
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.
Author : OECD
Publisher : OECD Publishing
Page : 15 pages
File Size : 38,52 MB
Release : 2006-08-17
Category :
ISBN : 9264067310
This Test Guideline is for an in vitro membrane barrier test method that can be used to identify corrosive substances. The test method utilizes an artificial membrane designed to respond to corrosive substances in a manner similar to animal skin in ...
Author : OECD
Publisher : OECD Publishing
Page : 15 pages
File Size : 49,49 MB
Release : 2015-07-28
Category :
ISBN : 9264242732
This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function.
Author : OECD
Publisher : OECD Publishing
Page : 29 pages
File Size : 14,27 MB
Release : 2019-06-18
Category :
ISBN : 9264264612
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
Author : OECD
Publisher : OECD Publishing
Page : 28 pages
File Size : 33,22 MB
Release : 2021-06-17
Category :
ISBN : 9264242848
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Author : OECD
Publisher : OECD Publishing
Page : 8 pages
File Size : 32,38 MB
Release : 2015-07-28
Category :
ISBN : 9264242678
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.
Author : OECD
Publisher : OECD Publishing
Page : 8 pages
File Size : 15,40 MB
Release : 2004-11-23
Category :
ISBN : 9264071083
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Author : OECD
Publisher : OECD Publishing
Page : 8 pages
File Size : 14,53 MB
Release : 2004-11-23
Category :
ISBN : 9264071067
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Author : OECD
Publisher : OECD Publishing
Page : 12 pages
File Size : 16,86 MB
Release : 2004-11-23
Category :
ISBN : 9264071121
The Globally Harmonised System for the Classification and Labelling of Chemicals defines skin corrosion as the production of irreversible tissue damage in the skin following the application of a test material. The test material (150 μL for liquids ...
Author : OECD
Publisher : OECD Publishing
Page : 20 pages
File Size : 44,43 MB
Release : 2009-09-08
Category :
ISBN : 9264070605
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
