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The Organic Chemistry of Drug Design and Drug Action

Author : Richard B. Silverman

Publisher : Elsevier

Page : 650 pages

File Size : 50,79 MB

Release : 2012-12-02

Category : Science

ISBN : 0080513379

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Book Description

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization



Chemistry in Action

Author : Nina Morgan

Publisher : Oxford University Press, USA

Page : 168 pages

File Size : 22,73 MB

Release : 1995

Category : Juvenile Nonfiction

ISBN :

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Book Description

Explanation of the fundamentals of chemistry including the chemical elements, organic chemistry, and biochemistry.



Organic Chemistry in Action

Author : F. Serratosa

Publisher : Elsevier

Page : 418 pages

File Size : 43,10 MB

Release : 2013-10-22

Category : Science

ISBN : 1483290921

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Book Description

Contrary to all other books in the field of organic synthesis, this volume combines Corey's methodology, which is based on the concept of synthon and retrosynthetic analysis, with Evans' methodology based on the `Lapworth model' of alternating polarities. Using this approach, the formation of carbon-carbon bonds and the manipulation of functional groups are treated together, whereas the stereochemical aspects are considered separately. Emphasis is laid on the importance of rigid structures, whether in the starting materials, the synthetic intermediates or the transition states, as a means of controlling the stereochemistry of the organic compounds. Enclosed with the book is a copy of a miniprogram (CHAOS) for an IBM PC, or fully compatible computers, which is an interactive program, affording the beginner a fast and easy way of learning, exploring and looking for new synthetic schemes of molecules of moderate complexity. As a textbook on organic synthesis, this volume will be of immense value at university level.



Chiral Drugs

Author : Guo-Qiang Lin

Publisher : John Wiley & Sons

Page : 469 pages

File Size : 45,97 MB

Release : 2011-08-08

Category : Science

ISBN : 1118075633

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Book Description

An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.



Chemistry in Action

Author : Michael Freemantle

Publisher :

Page : 882 pages

File Size : 40,86 MB

Release : 1987

Category : Chemical reaction, Rate of

ISBN : 9780333373101

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Book Description

The second revised edition of an accessible A-level chemistry text, containing additional worked examples and exercises, and covering new topics such as AIDS research, High Temperature Superconductivity and the greenhouse effect.



Reaction Mechanisms in Organic Chemistry

Author : Metin Balcı

Publisher : John Wiley & Sons

Page : 644 pages

File Size : 26,6 MB

Release : 2021-12-01

Category : Science

ISBN : 3527349642

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Book Description

An accessible and step-by-step exploration of organic reaction mechanisms In Reaction Mechanisms in Organic Chemistry, eminent researcher Dr. Metin Balci delivers an excellent textbook for understanding organic reaction mechanisms. The book offers a way for undergraduate and graduate students to understand???rather than memorize???the principles of reaction mechanisms. It includes the most important reaction types, including substitution, elimination, addition, pericyclic, and C-C coupling reactions. Each chapter contains problems and accompanying solutions that cover central concepts in organic chemistry. Students will learn to understand the foundational nature of ideas like Lewis acids and bases, electron density, the mesomeric effect, and the inductive effect via the use of detailed examples and an expansive discussion of the concept of hybridization. Along with sections covering aromaticity and the chemistry of intermediates, the book includes: A thorough introduction to basic concepts in organic reactions, including covalent bonding, hybridization, electrophiles and nucleophiles, and inductive and mesomeric effects Comprehensive explorations of nucleophilic substitution reactions, including optical activity and stereochemistry of SN2 reactions Practical discussions of elimination reactions, including halogene elimination and Hofmann elimination In-depth examinations of addition reactions, including the addition of water to alkenes and the epoxidation of alkenes Perfect for students of chemistry, biochemistry, and pharmacy, Reaction Mechanisms in Organic Chemistry will also earn a place in the libraries of researchers and lecturers in these fields seeking a one-stop resource on organic reaction mechanisms.



Clickers in Action

Author : Suzanne M. Ruder

Publisher : W. W. Norton

Page : 0 pages

File Size : 35,54 MB

Release : 2013

Category : Science

ISBN : 9780393935677

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Book Description

An instructor-oriented resource providing information on implementing clickers in organic chemistry courses. Part I gives instructors information on how to choose and manage a CRS system, develop effective questions, and integrate the questions into their courses. Part II contains 140 class-tested, lecture-ready questions. Most questions include histograms that show actual student response, generated in large classes with 200-300 students over multiple semesters. Each question also includes insights and suggestions for implementation.



Engaging Students in Organic Chemistry

Author : Barbara A. Murray

Publisher :

Page : 168 pages

File Size : 13,78 MB

Release : 2022-01-05

Category : Chemistry,CS Organic

ISBN : 9780841298446

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Book Description

Linking OChem to natural products, polymers, pharmaceuticals and more Organic chemistry educators have a critical role in engaging and improving student outcomes at a foundational level. The material in the traditional one-year sequence is foundational for upper level science courses as well as many pre-professional programs, such as medicine. When students are engaged in learning the fundamental concepts in organic chemistry, they are better prepared to apply organic concepts to other applications across chemistry. In this work, authors share methods for engaging students in organic chemistry, including in an online environment. These methods range from creative activities for individual class topics to pedagogical models utilized over an academic year. Laboratory experiments, writing assignments, and innovative assignments are included.



Organic Chemistry

Author : Robert J. Ouellette

Publisher : Academic Press

Page : 1058 pages

File Size : 40,85 MB

Release : 2018-02-03

Category : Technology & Engineering

ISBN : 0128128399

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Book Description

Organic Chemistry: Structure, Mechanism, Synthesis, Second Edition, provides basic principles of this fascinating and challenging science, which lies at the interface of physical and biological sciences. Offering accessible language and engaging examples and illustrations, this valuable introduction for the in-depth chemistry course engages students and gives future and new scientists a new approach to understanding, rather than merely memorizing the key concepts underpinning this fundamental area. The book builds in a logical way from chemical bonding to resulting molecular structures, to the corresponding physical, chemical and biological properties of those molecules. The book explores how molecular structure determines reaction mechanisms, from the smallest to the largest molecules—which in turn determine strategies for organic synthesis. The book then describes the synthetic principles which extend to every aspect of synthesis, from drug design to the methods cells employ to synthesize the molecules of which they are made. These relationships form a continuous narrative throughout the book, in which principles logically evolve from one to the next, from the simplest to the most complex examples, with abundant connections between the theory and applications. Featuring in-book solutions and instructor PowerPoint slides, this Second Edition offers an updated and improved option for students in the two-semester course and for scientists who require a high quality introduction or refresher in the subject. - Offers improvements for the two-semester course sequence and valuable updates including two new chapters on lipids and nucleic acids - Features biochemistry and biological examples highlighted throughout the book, making the information relevant and engaging to readers of all backgrounds and interests - Includes a valuable and highly-praised chapter on organometallic chemistry not found in other standard references



Writing Reaction Mechanisms in Organic Chemistry

Author : Kenneth A. Savin

Publisher : Academic Press

Page : 511 pages

File Size : 29,13 MB

Release : 2014-07-10

Category : Science

ISBN : 0124105092

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Book Description

Writing Reaction Mechanisms in Organic Chemistry, Third Edition, is a guide to understanding the movements of atoms and electrons in the reactions of organic molecules. Expanding on the successful book by Miller and Solomon, this new edition further enhances your understanding of reaction mechanisms in organic chemistry and shows that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions. The book has been extensively revised with new material including a completely new chapter on oxidation and reduction reactions including stereochemical reactions. It is also now illustrated with hundreds of colorful chemical structures to help you understand reaction processes more easily. The book also features new and extended problem sets and answers to help you understand the general principles and how to apply these to real applications. In addition, there are new information boxes throughout the text to provide useful background to reactions and the people behind the discovery of a reaction. This new edition will be of interest to students and research chemists who want to learn how to organize what may seem an overwhelming quantity of information into a set of simple general principles and guidelines for determining and describing organic reaction mechanisms. - Extensively rewritten and reorganized with a completely new chapter on oxidation and reduction reactions including stereochemical reactions - Essential for those who need to have mechanisms explained in greater detail than most organic chemistry textbooks provide - Now illustrated with hundreds of colorful chemical structures to help you understand reaction processes more easily - New and extended problem sets and answers to help you understand the general principles and how to apply this to real applications - New information boxes throughout the text to provide useful background to reactions and the people behind the discovery of a reaction