Author : Peter Gehr
Publisher : CRC Press
Page : 718 pages
File Size : 28,42 MB
Release : 2000-02-18
Category : Medical
ISBN : 0824746899
This wide-ranging, comprehensive reference presents the latest developments in aerosol science and interactions between particles and the respiratory tract-utilizing an inter-disciplinary approach that integrates advances in physics, chemistry, and engineering with the epidemiological and biomedical sciences, and focusing on the dynamics of particl
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
Page : 728 pages
File Size : 42,16 MB
Release : 2010
Category : Government publications
ISBN :
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : National Research Council (U.S.). Subcommittee on Airborne Particles
Publisher :
Page : 376 pages
File Size : 44,25 MB
Release : 1979
Category : Science
ISBN :
Author : Sponsored by The Health Effects Institute
Publisher : National Academies Press
Page : 703 pages
File Size : 27,33 MB
Release : 1988-01-01
Category : Science
ISBN : 0309037263
"The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.
Author : Ken Donaldson
Publisher : CRC Press
Page : 462 pages
File Size : 29,82 MB
Release : 2006-12-21
Category : Medical
ISBN : 1420003143
Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to transl
Author : Ali Nokhodchi
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 15,89 MB
Release : 2015-08-03
Category : Science
ISBN : 1118799542
Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.
Author : Peter Gehr
Publisher : CRC Press
Page : 823 pages
File Size : 39,96 MB
Release : 2000-02-18
Category : Medical
ISBN : 9780824798918
This wide-ranging, comprehensive reference presents the latest developments in aerosol science and interactions between particles and the respiratory tract-utilizing an inter-disciplinary approach that integrates advances in physics, chemistry, and engineering with the epidemiological and biomedical sciences, and focusing on the dynamics of particle deposition, retention, and clearance. Containing the work of more than 40 internationally recognized experts, Particle-Lung Interactions covers therapeutic and diagnostic aspects of particle inhalation surveys particles ranging in size from 0.01-10 microns interacting with pulmonary cells analyzes stereological estimation of particle retention reveals the sentinel of the pulmonary surveillance system highlights the correlation between particulate air pollution and cardiovascular mortality describes airborne irritants that activate neural reflexes investigates particulate matter in clearance kinetics and inflammatory responses in the lungs explores particle-surfactant interaction, keying on fine ambient particles at air-liquid interfaces and more! Abundantly referenced with over 2700 bibliographic citations, Particle-Lung Interactions is an indispensable resource for pulmonologists, physiologists, clinical immunologists, allergists, toxicologists, pediatricians and general practitioners, pharmacists, biochemists, surface physicists, and upper-level undergraduate, graduate, and medical school students in these disciplines.
Author : National Research Council
Publisher : National Academies Press
Page : 204 pages
File Size : 10,35 MB
Release : 1989-02-01
Category : Science
ISBN : 9780309039901
Biologic markersâ€"indicators of biological exposure or changeâ€"offer the promise of early detection of disease caused by environmental exposure. Researchers have used these markers to discover indications of pulmonary damage from low-level ozone, a finding with serious implications for health professionals and environmental regulators. Biologic Markers in Pulmonary Toxicology is a comprehensive study of this use of biologic markers. Focusing on the respiratory tract as an entryway for airborne pollutants, this volume reviews new ways of measuring markers, the need for markers to indicate dose or exposure levels, noninvasive respiratory function tests for use with healthy humans to detect sensitivity to inhaled pollutants, approaches to evaluating markers down to the cellular and biochemical levels, and more.
Author : Saura C. Sahu
Publisher : John Wiley & Sons
Page : 713 pages
File Size : 27,5 MB
Release : 2014-04-22
Category : Science
ISBN : 1118855868
The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
Author : Richard A. Parent
Publisher : Academic Press
Page : 835 pages
File Size : 44,2 MB
Release : 2015-03-13
Category : Medical
ISBN : 0124047262
Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. - Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings - Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung - Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more - Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system
