Pathology and Clinical Relevance of Neoplastic Precursor Lesions of the Tubal Gut, Liver, and Pancreaticobiliary System: A Contemporary Update, An Issue of Gastroenterology Clinics of North America, E-Book


Book Description

In this issue of Gastroenterology Clinics, guest editor Dr. Robert Odze brings his considerable expertise to the topic of Pathology and Clinical Relevance of Neoplastic Precursor Lesions of the Tubal Gut, Liver, and Pancreaticobiliary System: A Contemporary Update. Top experts review all the basic advances in the biology of neoplastic precursor lesions and its molecular and clinical implications to provide a better and more uniform understanding of mechanisms of cancer development in the gastrointestinal system and related organs. - Contains 10 relevant, practice-oriented topics including Barrett's esophagus and associated dysplasia; hepatic precancerous lesions and early hepatocellular carcinoma; pathology and clinical significance of inflammatory bowel disease-associated colorectal dysplastic lesions; sporadic colorectal polyps of the colon; pathology of gastrointestinal polyposis disorders; and more. - Provides in-depth clinical reviews on neoplastic precursor lesions of the tubal gut, liver, and pancreaticobiliary system, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.




WHO Classification of Tumours of the Digestive System


Book Description

"The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].




Pathology and Clinical Relevance of Neoplastic Precursor Lesions of the Gastrointestinal Tract, Liver, and Pancreaticobiliary System


Book Description

Due to recent advances in endoscopy and radiology, there is increased recognition of the prevalence and biological characteristics of neoplastic precursor lesions in the GI tract, liver, biliary tract, and pancreas. As a result, there have been major recent developments in the pathologic classification, diagnosis, molecular pathogenesis, natural history and treatment of these lesions. In addition, there are controversial issues with regard to the value of endoscopic screening and surveillance. A close clinician-pathologist interaction is essential in the management of preneoplastic lesions. In this issue the pathology, biological properties, pathogenesis, natural history, and current treatment recommendations of the major preneoplastic and dysplastic precursor lesions of the GI tract, liver, biliary tract and pancreas are reviewed in detail. Wherever possible, accent is given to controversial diagnostic and management-related issues. Each subject matter is written by experts in the field, all of whom have had research experience in their respective areas.




Clinical Pancreatology for Practising Gastroenterologists and Surgeons


Book Description

Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.




Modern Immunohistochemistry


Book Description

Since the publication of the first edition of this best-selling book in 2009, the field of immunohistochemistry has advanced significantly. Fully updated to reflect the latest developments in the field, Modern Immunohistochemistry, Second Edition, is a practical guide to all the important diagnostic markers in each organ system. Concise text is supplemented by over 1,100 high-quality colour images and algorithms. The new edition features even more summary tables, highlighting the key points of differential immunophenotypic panels. A new, expanded introduction explains the basic principles of immunohistochemistry, and chapters have been updated to incorporate predictive/prognostic markers and the latest WHO classifications. All chapters are written by the same expert authors, providing a consistent, engaging style throughout and avoiding contradictory advice. An essential text for residents, this is also an extremely valuable resource for practitioners in anatomic pathology wishing to familiarise themselves with diagnostic markers at a quick glance.




Tumors and Tumor-Like Lesions of the Hepatobiliary Tract


Book Description

This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.




Pancreatic Pathology


Book Description




Pancreatic Cancer


Book Description

The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.




WHO Classification of Tumours. Digestive System Tumours


Book Description

Digestive System Tumours is the first volume in the fifth edition of the WHO series on the classification of human tumors. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumors and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education.




The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology


Book Description

This text and the terminology developed by the Papanicolaou Society of Cytopathology (P.S.C.) represents an important advance in the field of pancreaticobiliary cytopathology. This textbook/atlas is designed to present a comprehensive and state of the art approach to the cytologic diagnosis and reporting of pancreaticobiliary lesions. Chapters address each of the diagnostic categories defined by the P.S.C. The definition of each category along with the clinical pathologic entities contained within the category are discussed along with specific cytologic criteria for inclusion of a cytologic specimen within the category. Each chapter is lavishly illustrated demonstrating diagnostic criteria and examples of lesions contained within the category. Additionally, appropriate ancillary testing is discussed and where appropriate illustrated. Each chapter concludes with a discussion of appropriate management as well as estimates of malignancy risk for the category. The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology: Definitions, Criteria, Ancillary Testing and Management will provide the reader with a unified approach to diagnosing and reporting interpretations of cytologic specimens obtained from the pancreaticobiliary tract. This text/atlas will serve as a reference guide for pathologists, surgeons, endoscopists and radiologists.